Pinto, A. K., A. M. Jamieson, D. H. Raulet, and A. B. Hill. 2007. The role of NKG2D signaling in inhibition of cytotoxic T-lymphocyte lysis by the Murine cytomegalovirus immunoevasin m152/gp40. J. Viro 81:12564-12571 .
... primed cytotoxic CD8 T lymphocytes (CTL) to kill virus-infected cells. Of these three, the impact of m152/gp40 on CTL lysis appears greater than would be expected based on its impact on cell surface major histocompatibility complex (MHC) class I. In addition to MHC class I, m152/gp40 also downregula ...
... primed cytotoxic CD8 T lymphocytes (CTL) to kill virus-infected cells. Of these three, the impact of m152/gp40 on CTL lysis appears greater than would be expected based on its impact on cell surface major histocompatibility complex (MHC) class I. In addition to MHC class I, m152/gp40 also downregula ...
IFN-γ + CD4 T Cells
... Experimental design for the protection studies in Guinea pigs. Different groups of Duncan-Hartley Guinea pigs were immunized with L91 or controls (F91, LH, BCG and placebo). Peptides were given at a dose of 100 nmol (primary immunization) and 50 nmol (booster). BCG (106 CFU/ animal) was given as a c ...
... Experimental design for the protection studies in Guinea pigs. Different groups of Duncan-Hartley Guinea pigs were immunized with L91 or controls (F91, LH, BCG and placebo). Peptides were given at a dose of 100 nmol (primary immunization) and 50 nmol (booster). BCG (106 CFU/ animal) was given as a c ...
Crossed signals: the role of interleukin-15 and
... discussed the role of the IL-12 and -17 families of cytokines. This review is focused on IL-15 and -18. Both these molecules have pro-inflammatory activity and act on many cell types and because of their broad spectrum of activity they play an important role in autoimmunity and disease pathogenesis. ...
... discussed the role of the IL-12 and -17 families of cytokines. This review is focused on IL-15 and -18. Both these molecules have pro-inflammatory activity and act on many cell types and because of their broad spectrum of activity they play an important role in autoimmunity and disease pathogenesis. ...
Use of HLA-B27 tetramers to identify low-frequency antigen
... reported on Chlamydia-specific CD8+ T cells capable of lysing target cells primed with Chlamydia antigens [10-12]. CD8+ T cell responses in spondylarthropathies other than Ct-ReA have also been described [13-15]. Recently a new method for antigen-specific T cell recognition has been established by u ...
... reported on Chlamydia-specific CD8+ T cells capable of lysing target cells primed with Chlamydia antigens [10-12]. CD8+ T cell responses in spondylarthropathies other than Ct-ReA have also been described [13-15]. Recently a new method for antigen-specific T cell recognition has been established by u ...
the effects of thymus and other lymphoid organs enclosed in
... rated pore size of 0.1/z. The manner of construction and sterilization was similar to that described in detail in a previous article (17). This type of chamber was first pretested for possible cell leakage by enclosing a solid block of Gross leukemia tissue within each chamber and inserting the whol ...
... rated pore size of 0.1/z. The manner of construction and sterilization was similar to that described in detail in a previous article (17). This type of chamber was first pretested for possible cell leakage by enclosing a solid block of Gross leukemia tissue within each chamber and inserting the whol ...
B Cells
... • Antigen receptors are generated by random rearrangement of DNA • As lymphocytes mature in bone marrow or the thymus, they are tested for self-reactivity • Lymphocytes with receptors specific for the body’s own molecules are destroyed by apoptosis, or rendered nonfunctional ...
... • Antigen receptors are generated by random rearrangement of DNA • As lymphocytes mature in bone marrow or the thymus, they are tested for self-reactivity • Lymphocytes with receptors specific for the body’s own molecules are destroyed by apoptosis, or rendered nonfunctional ...
LIPOPOLYSACCHARIDE-MEDIATED REGULATION OF IL-17 RECEPTOR LEVELS IN HUMAN MONOCYTES
... Figure 1: Different T cell lineages from naïve CD4+ T cell engagement with an antigen presenting cell. Th1 and Th2 were the first Th cell subsets to be classified, later followed by the Treg, and finally the Th17 cells. IL-12 which consists of p40 and p35 subunits binds IL-12Rβ1 and IL-12Rβ2 recept ...
... Figure 1: Different T cell lineages from naïve CD4+ T cell engagement with an antigen presenting cell. Th1 and Th2 were the first Th cell subsets to be classified, later followed by the Treg, and finally the Th17 cells. IL-12 which consists of p40 and p35 subunits binds IL-12Rβ1 and IL-12Rβ2 recept ...
Murine gammaherpesvirus-68 productively infects immature
... Fig. 1. cHV-68 infection of immature and mature DCs. (a) Immature DCs or DCs matured for 24 h with 100 ng LPS ml”1 were infected with cHV-eGFP and harvested 24 h later. Cells were stained with APC-conjugated CD11c and PE-conjugated CD86 mAbs. Cells were gated on CD11c+ (top panel) and analysed for e ...
... Fig. 1. cHV-68 infection of immature and mature DCs. (a) Immature DCs or DCs matured for 24 h with 100 ng LPS ml”1 were infected with cHV-eGFP and harvested 24 h later. Cells were stained with APC-conjugated CD11c and PE-conjugated CD86 mAbs. Cells were gated on CD11c+ (top panel) and analysed for e ...
Apoptotic Debris Accumulates on Hematopoietic Cells and
... and deficiency in DNase or RNase leads to poor lysosomal degradation (5). Although these defects heighten the burden of apoptotic debris and promote some of the phenotypes associated with lupus, ablation of opsonins or their receptors is insufficient to promote severe disease (6, 7). One consequence ...
... and deficiency in DNase or RNase leads to poor lysosomal degradation (5). Although these defects heighten the burden of apoptotic debris and promote some of the phenotypes associated with lupus, ablation of opsonins or their receptors is insufficient to promote severe disease (6, 7). One consequence ...
Automated Blood Cell Counts State of the Art
... calculate the total allowable error.54 ❚Table 2❚ compares the analytic goals obtained with this approach with the state of the art (total current error) obtained from the literature.1,55 The performance is satisfactory for the majority of parameters such as total WBC count, RBC count, hemoglobin con ...
... calculate the total allowable error.54 ❚Table 2❚ compares the analytic goals obtained with this approach with the state of the art (total current error) obtained from the literature.1,55 The performance is satisfactory for the majority of parameters such as total WBC count, RBC count, hemoglobin con ...
Inflammation and Cellular Immune Responses in Abdominal Aortic
... extensive perianeurysmal and retroperitoneal fibrosis, and dense adhesions of adjacent abdominal organs. Patients with such inflammatory aortic aneurysms more commonly present with a triad of abdominal or back pain, weight loss, and an elevated erythrocyte sedimentation rate (65% to 90% versus 8% to ...
... extensive perianeurysmal and retroperitoneal fibrosis, and dense adhesions of adjacent abdominal organs. Patients with such inflammatory aortic aneurysms more commonly present with a triad of abdominal or back pain, weight loss, and an elevated erythrocyte sedimentation rate (65% to 90% versus 8% to ...
The role of peanut-specific T cell
... memory Th cells. These differences are specific for peanut responses since we could not see any difference between PA and NA responses to a control food antigen (ovalbumin): in these donors control responses show no clear subset predominance of skin-homing or gut-homing memory Th cells. This result ...
... memory Th cells. These differences are specific for peanut responses since we could not see any difference between PA and NA responses to a control food antigen (ovalbumin): in these donors control responses show no clear subset predominance of skin-homing or gut-homing memory Th cells. This result ...
Anatomy and physiology of the nose and paranasal sinuses
... Is pyramidal in shape and occupies the body of the maxilla The base is medialy ,the apex in the zygomatic portion of the maxilla it is the largest of the sinuses with an average capacity of about 15 ml in the adult 4 major boundaries: the maxillary face anteriorly; the ascending process of the palat ...
... Is pyramidal in shape and occupies the body of the maxilla The base is medialy ,the apex in the zygomatic portion of the maxilla it is the largest of the sinuses with an average capacity of about 15 ml in the adult 4 major boundaries: the maxillary face anteriorly; the ascending process of the palat ...
Ethmoid Sinus
... Is pyramidal in shape and occupies the body of the maxilla The base is medialy ,the apex in the zygomatic portion of the maxilla it is the largest of the sinuses with an average capacity of about 15 ml in the adult 4 major boundaries: the maxillary face anteriorly; the ascending process of the palat ...
... Is pyramidal in shape and occupies the body of the maxilla The base is medialy ,the apex in the zygomatic portion of the maxilla it is the largest of the sinuses with an average capacity of about 15 ml in the adult 4 major boundaries: the maxillary face anteriorly; the ascending process of the palat ...
Mouse Bone Marrow and Peripheral Blood Erythroid Cell Counts
... chromosome were identified to give a genome wide screen at 15-20 cM intervals [20]. DNA was prepared from tails of the F2 mice. QTL Mapping and Statistical Analysis Trait data was normalised as appropriate (log transformation) and regressed onto age and sex, using residuals in the analysis. Windows ...
... chromosome were identified to give a genome wide screen at 15-20 cM intervals [20]. DNA was prepared from tails of the F2 mice. QTL Mapping and Statistical Analysis Trait data was normalised as appropriate (log transformation) and regressed onto age and sex, using residuals in the analysis. Windows ...
tuberculosis Mycobacterium Early Infection with Dynamic Roles of
... IFN upon IL-1b production, considered essential for the control of mycobacterial infection, in human macrophages (17). These discrepancies could be attributed to the fact that type I IFNs act differently on distinct cell types (18), and therefore, in vitro systems cannot reflect the sum of their eff ...
... IFN upon IL-1b production, considered essential for the control of mycobacterial infection, in human macrophages (17). These discrepancies could be attributed to the fact that type I IFNs act differently on distinct cell types (18), and therefore, in vitro systems cannot reflect the sum of their eff ...
Radiation Effects on the Blood-Forming System
... The mature functional blood cells can be divided into three main groups taking into account their morphological and functional peculiarities, namely, thrombocytes, erythrocytes, and leukocytes. The last group includes granulocytes and lymphocytes. Accordingly, the four major hematopoietic lines are ...
... The mature functional blood cells can be divided into three main groups taking into account their morphological and functional peculiarities, namely, thrombocytes, erythrocytes, and leukocytes. The last group includes granulocytes and lymphocytes. Accordingly, the four major hematopoietic lines are ...
ABSTRACT
... the structure to evade innate immunity [4]. There are several types of PRRs, including Toll-like receptors (TLRs), Nods/NALPs, mannose receptors, and scavenger receptors [5]. These receptors have different functions. Mannose receptors and scavenger receptors improve phagocytosis, allowing microbes t ...
... the structure to evade innate immunity [4]. There are several types of PRRs, including Toll-like receptors (TLRs), Nods/NALPs, mannose receptors, and scavenger receptors [5]. These receptors have different functions. Mannose receptors and scavenger receptors improve phagocytosis, allowing microbes t ...
Licentiate-thesis from the Department of Immunology, Wenner-Gren Institute, Stockholm University, Sweden
... clonal deletion and clonal anergy of antigen-specific CD4+ T cells4. This appears to happen after high-dose feeding. Many intestinal CD4+ T cells have been postulated to be regulatory T cells and thus important for maintaining local tolerance towards environmental antigens10. When IL-10 and TGFβ wer ...
... clonal deletion and clonal anergy of antigen-specific CD4+ T cells4. This appears to happen after high-dose feeding. Many intestinal CD4+ T cells have been postulated to be regulatory T cells and thus important for maintaining local tolerance towards environmental antigens10. When IL-10 and TGFβ wer ...
Embryology Lec6 Dr.Ban Tongue and Thyroid gland Development
... The thymus is a soft, roughly triangular specialized primary lymphoid organ of the immune system.Located in the upper chest region,It has two distinct but identical lobes that are each surrounded by a tough, fibrous capsule. Within each lobe is a superficial region of tissue called the cortex and a ...
... The thymus is a soft, roughly triangular specialized primary lymphoid organ of the immune system.Located in the upper chest region,It has two distinct but identical lobes that are each surrounded by a tough, fibrous capsule. Within each lobe is a superficial region of tissue called the cortex and a ...
Exosomes: secreted vesicles and intercellular
... and can affect the cells that encounter these structures in much more complex ways. Although known to exist for several decades (for instance, in blood, where they are generally called “microparticles”, or in seminal fluid, where they are called “prostasomes” [2]), membrane vesicles have long been t ...
... and can affect the cells that encounter these structures in much more complex ways. Although known to exist for several decades (for instance, in blood, where they are generally called “microparticles”, or in seminal fluid, where they are called “prostasomes” [2]), membrane vesicles have long been t ...
Gene, environment, microbiome and mucosal immune tolerance in
... Mucosal structure and function There are a variety of mucosal sites in humans, including the eye, respiratory tract, gastrointestinal tract and genitourinary tract, as well as mammary glands and serosal sites such as the pleural and peritoneal cavities [1416]. In addition, there are multiple subsit ...
... Mucosal structure and function There are a variety of mucosal sites in humans, including the eye, respiratory tract, gastrointestinal tract and genitourinary tract, as well as mammary glands and serosal sites such as the pleural and peritoneal cavities [1416]. In addition, there are multiple subsit ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.