Sequence analysis of T-cell repertoires in health and disease
... own cellular space. T cells, which mediate cellular immunity, express heterodimeric (αβ or γδ) cell surface receptors (T-cell receptors, or TCRs). The vast majority of these are αβ TCRs, which engage heterologous cells presenting peptide antigens bound to major histocompatibility complex (MHC) [22]. ...
... own cellular space. T cells, which mediate cellular immunity, express heterodimeric (αβ or γδ) cell surface receptors (T-cell receptors, or TCRs). The vast majority of these are αβ TCRs, which engage heterologous cells presenting peptide antigens bound to major histocompatibility complex (MHC) [22]. ...
Doctoral thesis from the Department of Immunology, the Wenner-Gren Institute,
... early childhood and to see if these features are altered in children that develop early allergy, in children latently infected by herpes viruses or born by preeclamptic mothers. In newborn mice, NK-cell function increases and expression of the different NK-cell receptors changes during the first wee ...
... early childhood and to see if these features are altered in children that develop early allergy, in children latently infected by herpes viruses or born by preeclamptic mothers. In newborn mice, NK-cell function increases and expression of the different NK-cell receptors changes during the first wee ...
Susceptibility to tuberculosis is associated with variants in
... The role of ASAP1 in macrophages, DCs and other immune cells has not been studied previously. To investigate it, we initially characterized the ASAP1 mRNA expression by quantitative reverse transcriptase-PCR (qRT-PCR) in primary leukocytes of healthy donors and found that monocytes, B lymphocytes, C ...
... The role of ASAP1 in macrophages, DCs and other immune cells has not been studied previously. To investigate it, we initially characterized the ASAP1 mRNA expression by quantitative reverse transcriptase-PCR (qRT-PCR) in primary leukocytes of healthy donors and found that monocytes, B lymphocytes, C ...
Paranasal Sinus Anatomy
... Forms by age 12 Anterior and posterior table Nasofrontal duct— misnomer Frontal recess ...
... Forms by age 12 Anterior and posterior table Nasofrontal duct— misnomer Frontal recess ...
State-of-the-art review about basophil research in immunology and
... hypersensitivity reactions. Although they do have this property, basophils play an important role against many parasites, as well24. Given their similarities to mast cells, basophils have often been neglected and considered as a "redundant" mast cell-like circulating population25; notwithstanding, s ...
... hypersensitivity reactions. Although they do have this property, basophils play an important role against many parasites, as well24. Given their similarities to mast cells, basophils have often been neglected and considered as a "redundant" mast cell-like circulating population25; notwithstanding, s ...
VacA`s Induction of VacA-Containing Vacuoles (VCVs) and Their
... its collateral damage by the production of cytokines from effector cells [29]. Due to H. pylori’s long co-evolution with humans, VacA was able to adapt to host defence mechanisms, allowing H. pylori to survive and thrive despite the presence of an acquired immune response. H. pylori’s effect on the ...
... its collateral damage by the production of cytokines from effector cells [29]. Due to H. pylori’s long co-evolution with humans, VacA was able to adapt to host defence mechanisms, allowing H. pylori to survive and thrive despite the presence of an acquired immune response. H. pylori’s effect on the ...
Counterparts − CD25 + Repertoires with CD4 Share Equally
... their development and functional activity have remained elusive. Studies of human CD4⫹CD25⫹ regulatory T cells have been even more limited (5–9). Despite the many unresolved questions regarding regulatory T cells, the general consensus is that both murine and human CD4⫹CD25⫹ T cells require activati ...
... their development and functional activity have remained elusive. Studies of human CD4⫹CD25⫹ regulatory T cells have been even more limited (5–9). Despite the many unresolved questions regarding regulatory T cells, the general consensus is that both murine and human CD4⫹CD25⫹ T cells require activati ...
Fundamentals of Immunology
... I MHC, have CD8 in membrane- the sappers of the immune response, in the sense of blowing things up or possibly the FBI in the sense that they check for misbehaving members of the body’s citizenry. ...
... I MHC, have CD8 in membrane- the sappers of the immune response, in the sense of blowing things up or possibly the FBI in the sense that they check for misbehaving members of the body’s citizenry. ...
Resveratrol decreases miR-155 levels by upregulating miR
... Tel: +33 380 39 62 11; Fax: +33 380 39 62 50; E-mail: jean-jacques.michaille@u-bourgogne.fr Tel: +1 614 292 3063; Fax: +1 614 292 3558. E-mail: carlo.croce@osumc.edu Running title: Resveratrol downregulates miR-155 through miR-663 Key words: Inflammation; miR-155; monocytes; resveratrol; THP-1 cells ...
... Tel: +33 380 39 62 11; Fax: +33 380 39 62 50; E-mail: jean-jacques.michaille@u-bourgogne.fr Tel: +1 614 292 3063; Fax: +1 614 292 3558. E-mail: carlo.croce@osumc.edu Running title: Resveratrol downregulates miR-155 through miR-663 Key words: Inflammation; miR-155; monocytes; resveratrol; THP-1 cells ...
Pathways Molecule-Dependent and
... Japanese encephalitis virus (JEV), which is a mosquito-borne member of the genus Flavivirus, such as West Nile and dengue viruses, is responsible for most acute and epidemic cases of viral encephalitis (22, 23). Approximately 60% of the world population inhabits JEV endemic areas, and the virus is c ...
... Japanese encephalitis virus (JEV), which is a mosquito-borne member of the genus Flavivirus, such as West Nile and dengue viruses, is responsible for most acute and epidemic cases of viral encephalitis (22, 23). Approximately 60% of the world population inhabits JEV endemic areas, and the virus is c ...
Strimvelis, Common name - autologous CD34+ - EMA
... bovine ADA (PEG-ADA), while not approved in Europe, is available in some Member States via compassionate use. Patients require ERT as either weekly or bi-weekly intramuscular injections in order to control disease symptoms. A retrospective study of the long-term effects of PEG-ADA treatment for 5 to ...
... bovine ADA (PEG-ADA), while not approved in Europe, is available in some Member States via compassionate use. Patients require ERT as either weekly or bi-weekly intramuscular injections in order to control disease symptoms. A retrospective study of the long-term effects of PEG-ADA treatment for 5 to ...
AAPC MEETING TUESDAY, JUNE 19, 2012
... The inner ear is a fluid filled sac encased in bone, which gives it maximum protection from injury. The organ for hearing is the cochlea (pronounced "cock-lee-uh"). It contains approximately 20,000 cells which can sense movement of the fluid. When these cells sense movement of the fluid, impulses a ...
... The inner ear is a fluid filled sac encased in bone, which gives it maximum protection from injury. The organ for hearing is the cochlea (pronounced "cock-lee-uh"). It contains approximately 20,000 cells which can sense movement of the fluid. When these cells sense movement of the fluid, impulses a ...
Innate immune responses of human tracheal epithelium to
... specific role of flagellin in the early phases of infection remains an open question. Toll-like receptor (TLR)5 is involved in the response of many cells to flagellin (9, 27), and the specific regions of TLR5 involved in binding flagellin monomers have been identified (25). A major area of controver ...
... specific role of flagellin in the early phases of infection remains an open question. Toll-like receptor (TLR)5 is involved in the response of many cells to flagellin (9, 27), and the specific regions of TLR5 involved in binding flagellin monomers have been identified (25). A major area of controver ...
FVIII Immunity: Early Events and Tolerance Mechanisms to FVIII
... which are essential for the formation of FVIII antibodies in hemophilic mice. ………………………………………………….………………..29 Figure 2.2 Comparison of FVIII inhibitors and anti-FVIII IgG subclasses C57BL/6 and Balb/c mice after 4 FVIII treatments………………..37 Figure 2.3 Detection of Th1 and Th2 cytokines release by spl ...
... which are essential for the formation of FVIII antibodies in hemophilic mice. ………………………………………………….………………..29 Figure 2.2 Comparison of FVIII inhibitors and anti-FVIII IgG subclasses C57BL/6 and Balb/c mice after 4 FVIII treatments………………..37 Figure 2.3 Detection of Th1 and Th2 cytokines release by spl ...
Nanoparticle surface charge impacts distribution, uptake and lymph
... properties, lung deposition, and cellular interactions are independently taken into consideration. 1,2,8,9 While there is extensive literature describing how physical particle properties can influence aerodynamic diameter and thus pulmonary deposition, there is minimal understanding of how these sam ...
... properties, lung deposition, and cellular interactions are independently taken into consideration. 1,2,8,9 While there is extensive literature describing how physical particle properties can influence aerodynamic diameter and thus pulmonary deposition, there is minimal understanding of how these sam ...
A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade
... CD206+, CD64+, CD68+, CD11c+ CD115low, and CD102+, confirming they were macrophages but were different from Kupffer cells (Figure S1). Furthermore, CD102 has been identified as a specific marker for resident peritoneal macrophages and was present on macrophages in injury but not on Kupffer cells (Ok ...
... CD206+, CD64+, CD68+, CD11c+ CD115low, and CD102+, confirming they were macrophages but were different from Kupffer cells (Figure S1). Furthermore, CD102 has been identified as a specific marker for resident peritoneal macrophages and was present on macrophages in injury but not on Kupffer cells (Ok ...
Induction of Th2 type immunity in a mouse system
... blocking antibody (2.4G2), cells were then labeled with anti-Fc⑀RI–FITC (MAR-1; eBioscience, San Diego, CA) and incubated with anti-FITC microbeads (Miltenyi Biotec, Auburn, CA). Fc⑀RI-expressing basophils were enriched by positive magnetic separation (Miltenyi Biotec) and then subsequently purified ...
... blocking antibody (2.4G2), cells were then labeled with anti-Fc⑀RI–FITC (MAR-1; eBioscience, San Diego, CA) and incubated with anti-FITC microbeads (Miltenyi Biotec, Auburn, CA). Fc⑀RI-expressing basophils were enriched by positive magnetic separation (Miltenyi Biotec) and then subsequently purified ...
Experimental Biology and Medicine
... Exaggerated T-helper 2 (Th2)-biased immune responses result in the development of asthma.1 Immunotherapies that can regulate an allergen-specific Th2 immune response may provide long-lasting control of asthma. Recently, there have been an increasing number of studies demonstrating a therapeutic role ...
... Exaggerated T-helper 2 (Th2)-biased immune responses result in the development of asthma.1 Immunotherapies that can regulate an allergen-specific Th2 immune response may provide long-lasting control of asthma. Recently, there have been an increasing number of studies demonstrating a therapeutic role ...
Pinto, A. K., A. M. Jamieson, D. H. Raulet, and A. B. Hill. 2007. The role of NKG2D signaling in inhibition of cytotoxic T-lymphocyte lysis by the Murine cytomegalovirus immunoevasin m152/gp40. J. Viro 81:12564-12571 .
... primed cytotoxic CD8 T lymphocytes (CTL) to kill virus-infected cells. Of these three, the impact of m152/gp40 on CTL lysis appears greater than would be expected based on its impact on cell surface major histocompatibility complex (MHC) class I. In addition to MHC class I, m152/gp40 also downregula ...
... primed cytotoxic CD8 T lymphocytes (CTL) to kill virus-infected cells. Of these three, the impact of m152/gp40 on CTL lysis appears greater than would be expected based on its impact on cell surface major histocompatibility complex (MHC) class I. In addition to MHC class I, m152/gp40 also downregula ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.