2015 Annual Report - Maryland Stem Cell Research Fund
... in GCase. We found that when iPSC with GCase mutations were differentiated to neurons there was a 50-95% selective loss of dopaminergic neurons, compared to iPSC controls. We also found that the extent of the neuronal loss depended on how inactivating the mutations were. Further analysis showed that ...
... in GCase. We found that when iPSC with GCase mutations were differentiated to neurons there was a 50-95% selective loss of dopaminergic neurons, compared to iPSC controls. We also found that the extent of the neuronal loss depended on how inactivating the mutations were. Further analysis showed that ...
The NeuronDoctrine: A Revision of Functional
... the morphological neuron is a single functional entity, and all types of neurons are functionally similar or equivalent. Bullock(2) previously pointed out the inadequacy of this view, particularly with regard to invertebrate neurons. That this notion should have prevailed for so long in the mammalia ...
... the morphological neuron is a single functional entity, and all types of neurons are functionally similar or equivalent. Bullock(2) previously pointed out the inadequacy of this view, particularly with regard to invertebrate neurons. That this notion should have prevailed for so long in the mammalia ...
VI. The vertebrate nervous system is a hierarchy of structural and
... ⇒ Axons conduct impulses away from the cell body; are long, single processes. ◊ Vertebrate axons in PNS are wrapped in concentric layers of Schwann cells which form an insulating myelin sheath. ◊ Axons extend from the axon hillock (where impulses are generated) to many branches called telodendria, w ...
... ⇒ Axons conduct impulses away from the cell body; are long, single processes. ◊ Vertebrate axons in PNS are wrapped in concentric layers of Schwann cells which form an insulating myelin sheath. ◊ Axons extend from the axon hillock (where impulses are generated) to many branches called telodendria, w ...
MicroRNA ablation affects Bergmann glial morphology and disrupts
... However, miRNA functions during cerebellar development have not been systematically characterized. Here we conditionally knockout Dicer gene under the activity of human glial fibrillary acidic protein (hGFAP) promoter to examine the effect of miRNAs in the developing cerebellum. We found that ablati ...
... However, miRNA functions during cerebellar development have not been systematically characterized. Here we conditionally knockout Dicer gene under the activity of human glial fibrillary acidic protein (hGFAP) promoter to examine the effect of miRNAs in the developing cerebellum. We found that ablati ...
Cross-modal and cross-temporal association in neurons of frontal
... sensory information in behavioural and linguistic sequences1,2. Such information is commonly encoded in more than one sense modality, notably sight and sound. Connections from sensory cortices to the prefrontal cortex support its integrative function3±5. Here we present the ®rst evidence that prefro ...
... sensory information in behavioural and linguistic sequences1,2. Such information is commonly encoded in more than one sense modality, notably sight and sound. Connections from sensory cortices to the prefrontal cortex support its integrative function3±5. Here we present the ®rst evidence that prefro ...
Release of chemical transmitters from cell bodies and dendrites of
... One can speculate that oxytocin and vasopressin act as hormone-like signals on distant brain targets. The slow prolonged action on specific peptide receptors has been shown to trigger a temporary functional reorganization of neuronal networks and thereby induce prolonged changes in behaviour. The pr ...
... One can speculate that oxytocin and vasopressin act as hormone-like signals on distant brain targets. The slow prolonged action on specific peptide receptors has been shown to trigger a temporary functional reorganization of neuronal networks and thereby induce prolonged changes in behaviour. The pr ...
From the Eye to the Brain: Development of the Drosophila
... M6 referred to as “distal medulla” that receives these external inputs (Fischbach & Dittrich, 1989; Morante & Desplan, 2008; Takemura, Lu, & Meinertzhagen, 2008). The “proximal medulla” (layers M7–M10) receives information from the distal medulla and further computes visual information. The medulla ...
... M6 referred to as “distal medulla” that receives these external inputs (Fischbach & Dittrich, 1989; Morante & Desplan, 2008; Takemura, Lu, & Meinertzhagen, 2008). The “proximal medulla” (layers M7–M10) receives information from the distal medulla and further computes visual information. The medulla ...
The Neural Basis of Visually Guided Behavior
... grees; the toads turned away from larger squares. Vertical bars were ineffective as prey ob jects-and increasingly ineffective with increasing height. Horizontal (wormlike) bars were increasingly effective as prey ohjects with increasing length, up to a limit. Double bars (a horizontal bar plus a v ...
... grees; the toads turned away from larger squares. Vertical bars were ineffective as prey ob jects-and increasingly ineffective with increasing height. Horizontal (wormlike) bars were increasingly effective as prey ohjects with increasing length, up to a limit. Double bars (a horizontal bar plus a v ...
sense organs
... – a person’s sweat and vaginal secretions affect other people’s sexual physiology • dormitory effect ...
... – a person’s sweat and vaginal secretions affect other people’s sexual physiology • dormitory effect ...
Spinal Cord Tutorial 101
... regenerate past the lesion site. These proteins act as roadmaps, steering axons to their correct targets. This is a critical function because even if axons do survive, they must reconnect with the correct targets. Labs pursuing this approach include the Black Lab, the Mendell Lab, and the Parada Lab ...
... regenerate past the lesion site. These proteins act as roadmaps, steering axons to their correct targets. This is a critical function because even if axons do survive, they must reconnect with the correct targets. Labs pursuing this approach include the Black Lab, the Mendell Lab, and the Parada Lab ...
Cell dispersion patterns in different cortical regions
... blue and white stripes coming from parasagittal sections at two of three distances from the midline (e.g. 1.2-1.3 mm from the midline; 1.8-2.3 mm from the midline; or 2.6-2.9 mm from the midline). To confirm that stripes were radially sectioned, stripes embedded in methacrylate were focussed through ...
... blue and white stripes coming from parasagittal sections at two of three distances from the midline (e.g. 1.2-1.3 mm from the midline; 1.8-2.3 mm from the midline; or 2.6-2.9 mm from the midline). To confirm that stripes were radially sectioned, stripes embedded in methacrylate were focussed through ...
New dimensions of interneuronal specialization unmasked by
... distinct regions along the axo-somato-dendritic axis of postsynaptic principal cells (PC). These cell types can also be further subdivided, for example by additional molecular markers or developmental origin. (b) SCA cells are dendritically targeting, display an adapting firing pattern in response t ...
... distinct regions along the axo-somato-dendritic axis of postsynaptic principal cells (PC). These cell types can also be further subdivided, for example by additional molecular markers or developmental origin. (b) SCA cells are dendritically targeting, display an adapting firing pattern in response t ...
- Abdel Hamid Derm Atlas
... toxic metals like Cad, Hg, Pb .Therefore, these melanocytes protects the brain against promotion of neurodegenerative conditions.( Zecca, L. et al. Neuroscience 73: 4O7,1996) @ Melanin rich cells in substantia nigra are the ones most likely to be destroyed in people who have parkinsonism resulting i ...
... toxic metals like Cad, Hg, Pb .Therefore, these melanocytes protects the brain against promotion of neurodegenerative conditions.( Zecca, L. et al. Neuroscience 73: 4O7,1996) @ Melanin rich cells in substantia nigra are the ones most likely to be destroyed in people who have parkinsonism resulting i ...
The Spinal Cord - Lightweight OCW University of Palestine
... process. The neuron is responsible for sending and receiving impulses or signals. Each nerve cell consist of: 1. Cell body (Soma): which contains the nucleus and the other organelles necessary for cellular function. 2. Several short processes called dendrites: are the region where one neuron receive ...
... process. The neuron is responsible for sending and receiving impulses or signals. Each nerve cell consist of: 1. Cell body (Soma): which contains the nucleus and the other organelles necessary for cellular function. 2. Several short processes called dendrites: are the region where one neuron receive ...
Subventricular zone
The subventricular zone (SVZ) is a paired brain structure situated throughout the lateral walls of the lateral ventricles. It is composed of four distinct layers of variable thickness and cell density, as well as cellular composition. Along with the dentate gyrus of the hippocampus, the SVZ is one of two places where neurogenesis has been found to occur in the adult mammalian brain.