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... acting compounds, like the first psychotropic drugs that led to modern pharmacological treatment of psychiatric diseases (Ban, 2006). Although a detailed understanding of the pathophysiology and etiology of CNS disorders remains elusive, the last decade has witnessed a huge leap in our understanding ...
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... refined and fine-grained parcellation of these large-scale networks into a multitude of smaller constituents (Kiviniemi et al. 2009; Abou-Elseoud et al. 2010; Allen et al. 2011), and also shows that these networks are not conditional upon a task-free resting state but are equally involved in task perf ...
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uncorrected page page page proofs

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... regions (Leloup et al. 1994; Brant et al. 1993), which may suggest that alloxan administered i.c.v. might enter those brain cells that express GLUT-2. Furthermore, specific inhibition of GLUT2 in arcuate nucleus has been found to modulate nervous control of insulin secretion (Leloup et al., 1998). T ...
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Central Nervous System Permeation of Ibuprofen, Ketoprofen and

... of sophisticated barrier systems between the CNS and blood. The blood-brain barrier (BBB) between cerebral blood and the interstitial fluid of the brain, and the blood-cerebrospinal fluid barrier (BCSFB) between blood and ventricular and subarachnoid cerebrospinal fluid (CSF), both act as physical, ...
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Blood–brain barrier



The blood–brain barrier (BBB) is a highly selective permeability barrier that separates the circulating blood from the brain extracellular fluid (BECF) in the central nervous system (CNS). The blood–brain barrier is formed by brain endothelial cells, which are connected by tight junctions with an extremely high electrical resistivity of at least 0.1 Ω⋅m. The blood–brain barrier allows the passage of water, some gases, and lipid-soluble molecules by passive diffusion, as well as the selective transport of molecules such as glucose and amino acids that are crucial to neural function. On the other hand, the blood–brain barrier may prevent the entry of lipophilic, potential neurotoxins by way of an active transport mechanism mediated by P-glycoprotein. Astrocytes are necessary to create the blood–brain barrier. A small number of regions in the brain, including the circumventricular organs (CVOs), do not have a blood–brain barrier.The blood–brain barrier occurs along all capillaries and consists of tight junctions around the capillaries that do not exist in normal circulation. Endothelial cells restrict the diffusion of microscopic objects (e.g., bacteria) and large or hydrophilic molecules into the cerebrospinal fluid (CSF), while allowing the diffusion of small hydrophobic molecules (O2, CO2, hormones). Cells of the barrier actively transport metabolic products such as glucose across the barrier with specific proteins. This barrier also includes a thick basement membrane and astrocytic endfeet.
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