Vascular Spasm in Cat Cerebral Cortex
... cortical areas of impaired reperfusion following total circulatory arrest in monkeys. By utilizing the technique of injecting a carbon black suspension just prior to termination of the experiment they show coronal brain sections having large cortical areas devoid of carbon black. Other investigators ...
... cortical areas of impaired reperfusion following total circulatory arrest in monkeys. By utilizing the technique of injecting a carbon black suspension just prior to termination of the experiment they show coronal brain sections having large cortical areas devoid of carbon black. Other investigators ...
Cortical surface area and cortical thickness in the precuneus
... cells within a given column. Therefore, these two variables can give a reliable quantification of factors involved in cortical volume differences. We also evaluate, by using the shape groups evidenced in our previous study (Bruner et al., 2014a), whether precuneal thickness and surface area are involv ...
... cells within a given column. Therefore, these two variables can give a reliable quantification of factors involved in cortical volume differences. We also evaluate, by using the shape groups evidenced in our previous study (Bruner et al., 2014a), whether precuneal thickness and surface area are involv ...
Pregnane X Receptor Up-Regulation of P
... 6-h exposure to PCN in vitro. A, confocal image of a control capillary after 60-min incubation in medium with 2 M NBD-CSA. Note luminal accumulation of the p-glycoprotein substrate. Scale bar, 10 m. B, a representative dose-response experiment. Each point represents the mean value (arbitrary fluor ...
... 6-h exposure to PCN in vitro. A, confocal image of a control capillary after 60-min incubation in medium with 2 M NBD-CSA. Note luminal accumulation of the p-glycoprotein substrate. Scale bar, 10 m. B, a representative dose-response experiment. Each point represents the mean value (arbitrary fluor ...
Novel cyclic AMP signalling avenues in learning and memory
... AKAP79/150 family tethers PKA, PKC and PP2B to neuronal membranes and postsynaptic densities and plays an important role in synaptic function. Several studies suggested that AKAP79/150 anchored PKA contributes to mechanisms associated with synaptic plasticity and memory processes, but the precise ro ...
... AKAP79/150 family tethers PKA, PKC and PP2B to neuronal membranes and postsynaptic densities and plays an important role in synaptic function. Several studies suggested that AKAP79/150 anchored PKA contributes to mechanisms associated with synaptic plasticity and memory processes, but the precise ro ...
292(1):94-106
... anteroposterior markers krox20 and pax2a, and the dorsoventral patterning markers shh and zic1. No abnormalities are obvious, although we cannot exclude subtle perturbations (data not shown). All 13 early mutants appear to have brain ventricles of reduced size, as assayed by brightfield microscopy. ...
... anteroposterior markers krox20 and pax2a, and the dorsoventral patterning markers shh and zic1. No abnormalities are obvious, although we cannot exclude subtle perturbations (data not shown). All 13 early mutants appear to have brain ventricles of reduced size, as assayed by brightfield microscopy. ...
Hepatic and Central Nervous System Cytochrome P450 Are Down
... glial cells, can produce a large number of responses involving the autonomic, endocrine, and behavioral systems (Rothwell et al., 1996). Recently, we have shown that the regulation of cytochrome P450 forms in the rat brain and in astrocyte cultures is disturbed during the activation of an inflammato ...
... glial cells, can produce a large number of responses involving the autonomic, endocrine, and behavioral systems (Rothwell et al., 1996). Recently, we have shown that the regulation of cytochrome P450 forms in the rat brain and in astrocyte cultures is disturbed during the activation of an inflammato ...
Chapter 21: Attention
... Slide 10 Neuroscience: Exploring the Brain, 3rd Ed, Bear, Connors, and Paradiso Copyright © 2007 Lippincott Williams & Wilkins ...
... Slide 10 Neuroscience: Exploring the Brain, 3rd Ed, Bear, Connors, and Paradiso Copyright © 2007 Lippincott Williams & Wilkins ...
CNS Drug Design: Balancing Physicochemical
... United States among males younger than 40 years and females younger than 20 years.4 Patients who present with metastatic brain cancer have a poor prognosis with a median survival of only 2.5 months,5 which is at least partially a consequence of poor CNS exposure for currently available drugs that we ...
... United States among males younger than 40 years and females younger than 20 years.4 Patients who present with metastatic brain cancer have a poor prognosis with a median survival of only 2.5 months,5 which is at least partially a consequence of poor CNS exposure for currently available drugs that we ...
EEG - OCIBME
... How accurately is it possible to know the thoughts in the brain from the EEG signals? The ECG is described as a vector field? Why not the EEG? What is the frequency content of EEG signals? Is this lower of higher than ECG / EMG? Why do EEG signals not appear to be stochastic noise ...
... How accurately is it possible to know the thoughts in the brain from the EEG signals? The ECG is described as a vector field? Why not the EEG? What is the frequency content of EEG signals? Is this lower of higher than ECG / EMG? Why do EEG signals not appear to be stochastic noise ...
accepted manuscript - Radboud Repository
... Non-invasive measuring methods such as EEG/MEG, fMRI and DTI are increasingly utilised to extract quantitative information on functional and anatomical connectivity in the human brain. These methods typically register their data in Euclidean space, so that one can refer to a particular activity patt ...
... Non-invasive measuring methods such as EEG/MEG, fMRI and DTI are increasingly utilised to extract quantitative information on functional and anatomical connectivity in the human brain. These methods typically register their data in Euclidean space, so that one can refer to a particular activity patt ...
the addicted brain and new treatment frontiers
... to build a live and virtual network of innovators that will lead to new collaborations and breakthroughs. We hope that this conference will provide a unique forum for communication between scientists, clinicians, and other specialists who are directly involved in the treatment of patients with subst ...
... to build a live and virtual network of innovators that will lead to new collaborations and breakthroughs. We hope that this conference will provide a unique forum for communication between scientists, clinicians, and other specialists who are directly involved in the treatment of patients with subst ...
Expression and Functional Interaction of Hepatocyte Growth Factor
... and the septum, as well as in the pons. In the embryonic mouse, brain HGF-SF and c-met are expressed as early as days 12 and 13, respectively. Neuronal expression of HGF-SF is evolutionary highly conserved and detectable beyond the mammalian class. Incubation of septal neurons in culture with HGF-SF ...
... and the septum, as well as in the pons. In the embryonic mouse, brain HGF-SF and c-met are expressed as early as days 12 and 13, respectively. Neuronal expression of HGF-SF is evolutionary highly conserved and detectable beyond the mammalian class. Incubation of septal neurons in culture with HGF-SF ...
Bodies Human Exhibit Guide
... there is a blockage or interruption of blood flow to a part of the brain that results in death of brain tissue due to lack of oxygen. Multiple sclerosis is a disabling disorder that affects the nerve cells of the central nervous system (brain and spinal cord). The immune system attacks the fatty, pr ...
... there is a blockage or interruption of blood flow to a part of the brain that results in death of brain tissue due to lack of oxygen. Multiple sclerosis is a disabling disorder that affects the nerve cells of the central nervous system (brain and spinal cord). The immune system attacks the fatty, pr ...
Lesson plans
... The nervous tissue displays electrical activity. This electrical activity is in the form of a nerve impulse, which is a flow of electrical charges along the cell membrane. This flow is due to movement of ions across the membrane. A nerve cell has an electrical potential or voltage across its cell me ...
... The nervous tissue displays electrical activity. This electrical activity is in the form of a nerve impulse, which is a flow of electrical charges along the cell membrane. This flow is due to movement of ions across the membrane. A nerve cell has an electrical potential or voltage across its cell me ...
ELECTROENCEPHALOGRAM_(EEG).
... only frequency group found in every part of the brain. • When the brain needs to simultaneously process information from different areas, its hypothesized that the 40Hz activity consolidates the required areas for simultaneous processing. • A good memory is associated with well-regulated and efficie ...
... only frequency group found in every part of the brain. • When the brain needs to simultaneously process information from different areas, its hypothesized that the 40Hz activity consolidates the required areas for simultaneous processing. • A good memory is associated with well-regulated and efficie ...
Introduction to Neurophysiology
... It is likely that a similar mechanism is involved in all three types of autoregulation. Removal of the endothelium significantly reduces the contractions generated in response to various vasoconstrictors and hypoxia. The observation that rapid elevation of transmural pressure triggers vasoconstricti ...
... It is likely that a similar mechanism is involved in all three types of autoregulation. Removal of the endothelium significantly reduces the contractions generated in response to various vasoconstrictors and hypoxia. The observation that rapid elevation of transmural pressure triggers vasoconstricti ...
Powerpoint Slides
... • Within a functional region there can be populations that code for different features ...
... • Within a functional region there can be populations that code for different features ...
Cardiovascular System Part 2
... • Simple squamous epithelium lines inside of lymph vessels; few collagenous fiber cells; squamous cells at distal end of capillary overlap, forming one-way valve to allow fluid to flow into capillary and prevent backflow • Lymphatic tissue is specialized form of netlike connective tissue in lymphati ...
... • Simple squamous epithelium lines inside of lymph vessels; few collagenous fiber cells; squamous cells at distal end of capillary overlap, forming one-way valve to allow fluid to flow into capillary and prevent backflow • Lymphatic tissue is specialized form of netlike connective tissue in lymphati ...
Timing of Impulses From the Central Amygdala and Bed Nucleus of
... Evoked responses were recorded in CE and BNST with highimpedance (10 –12 M⍀) tungsten microelectrodes (FHC, Bowdoin, ME). The positions of the microlectrodes were adjusted independently with micromanipulators. A subset of rats was prepared with electrolytic lesions of the stria terminalis. Such lesi ...
... Evoked responses were recorded in CE and BNST with highimpedance (10 –12 M⍀) tungsten microelectrodes (FHC, Bowdoin, ME). The positions of the microlectrodes were adjusted independently with micromanipulators. A subset of rats was prepared with electrolytic lesions of the stria terminalis. Such lesi ...
Blunted Brain Energy Consumption Relates to Insula
... consumption alters brain energy levels. Because obese individuals display not only reduced cerebral ATP and PCr levels but also lower gray matter density (10–12) and cortical metabolism (8) compared with normal-weight individuals, we likewise hypothesized that the morphometric decline could be due t ...
... consumption alters brain energy levels. Because obese individuals display not only reduced cerebral ATP and PCr levels but also lower gray matter density (10–12) and cortical metabolism (8) compared with normal-weight individuals, we likewise hypothesized that the morphometric decline could be due t ...
Embryonic development of the Drosophila brain: formation of
... the midline at the same time. As soon as the first commissural axonal pathway in the brain across the midline is established, it is followed by other fasciculating commissural axons and, during subsequent embryogenesis, this commissural fascicle differentiates further to become the massive preoral c ...
... the midline at the same time. As soon as the first commissural axonal pathway in the brain across the midline is established, it is followed by other fasciculating commissural axons and, during subsequent embryogenesis, this commissural fascicle differentiates further to become the massive preoral c ...
Emerging Evidence for a Central Epinephrine-Innervated a1
... taut horizontal wire; by contrast, akinetic chlordiazepoxidetreated mice fell off within 10 s. The animals showed a slowed respiratory rate and hypothermia but had only a slight reduction in blood pressure (5 mmHg). To verify that the immobility was the result of a1-receptor blockade rather than som ...
... taut horizontal wire; by contrast, akinetic chlordiazepoxidetreated mice fell off within 10 s. The animals showed a slowed respiratory rate and hypothermia but had only a slight reduction in blood pressure (5 mmHg). To verify that the immobility was the result of a1-receptor blockade rather than som ...
Improving Blood Brain Barrier Permeation of Small
... agent paclitaxel were investigated in which chemical modification was employed to reduce interaction with the efflux transporter P-glycoprotein, which is critical in limiting paclitaxel’s entry into the brain. TH-237A, another microtubule stabilizing agent that is structurally very different from pa ...
... agent paclitaxel were investigated in which chemical modification was employed to reduce interaction with the efflux transporter P-glycoprotein, which is critical in limiting paclitaxel’s entry into the brain. TH-237A, another microtubule stabilizing agent that is structurally very different from pa ...
Brain Uncoupling Protein 2: Uncoupled Neuronal Mitochondria
... axons and axon terminals. UCP2-producing neurons were found to be the targets of peripheral hormones, including leptin and gonadal steroids, and the presence of UCP2 protein in axonal processes predicted increased local brain mitochondrial uncoupling activity and heat production. In the hypothalamus ...
... axons and axon terminals. UCP2-producing neurons were found to be the targets of peripheral hormones, including leptin and gonadal steroids, and the presence of UCP2 protein in axonal processes predicted increased local brain mitochondrial uncoupling activity and heat production. In the hypothalamus ...
Electric Cures - Bioelectronic Medicine could create an `off switch` for
... these accounts, centered on the workings of lymphocytes, monocytes, macrophages and other white blood cells, but not neurons. The inflammatory reflex, which keeps the immune system from becoming overactive or underactive, is the name I gave the circuit that prevents toxicity and tissue damage. When ...
... these accounts, centered on the workings of lymphocytes, monocytes, macrophages and other white blood cells, but not neurons. The inflammatory reflex, which keeps the immune system from becoming overactive or underactive, is the name I gave the circuit that prevents toxicity and tissue damage. When ...
Blood–brain barrier
The blood–brain barrier (BBB) is a highly selective permeability barrier that separates the circulating blood from the brain extracellular fluid (BECF) in the central nervous system (CNS). The blood–brain barrier is formed by brain endothelial cells, which are connected by tight junctions with an extremely high electrical resistivity of at least 0.1 Ω⋅m. The blood–brain barrier allows the passage of water, some gases, and lipid-soluble molecules by passive diffusion, as well as the selective transport of molecules such as glucose and amino acids that are crucial to neural function. On the other hand, the blood–brain barrier may prevent the entry of lipophilic, potential neurotoxins by way of an active transport mechanism mediated by P-glycoprotein. Astrocytes are necessary to create the blood–brain barrier. A small number of regions in the brain, including the circumventricular organs (CVOs), do not have a blood–brain barrier.The blood–brain barrier occurs along all capillaries and consists of tight junctions around the capillaries that do not exist in normal circulation. Endothelial cells restrict the diffusion of microscopic objects (e.g., bacteria) and large or hydrophilic molecules into the cerebrospinal fluid (CSF), while allowing the diffusion of small hydrophobic molecules (O2, CO2, hormones). Cells of the barrier actively transport metabolic products such as glucose across the barrier with specific proteins. This barrier also includes a thick basement membrane and astrocytic endfeet.