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RNA-protein interaction
RNA-protein interaction

... RNA and proteins are two kinds of most important molecules in cells. The interaction between proteins and RNA is one of the key issues in molecular biology. ...
Chapter 13 Lecture Notes: DNA Function I. Transcription (General
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Written Transcript of this video lesson in English (PDF

... The  cell  is  a  fundamental  unit  of  structure  and  function  in  living   organisms,  all  living  things  are  made  of  one  or  more  cells,   surrounded  by  a  membrane  contains  the  cytoplasm  inside  in  which   cell ...
Written Transcript of this video lesson in English
Written Transcript of this video lesson in English

... responsible for determining the characteristics of living things as a result of controlling a series of biochemical reactions inside living things. It consists of two wound strands of nucleotides to form a spiral ladder-shaped molecule .Each nucleotide consists of one of four nitrogen bases which ar ...
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Gene Expression
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... Translation • Once the gene has been transcribed into mRNA, the message must be translated to build a protein. • Ribosomes (made of rRNA) “read” the mRNA message and use the information to assemble amino acids. ...
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Ribosome



The ribosome (/ˈraɪbɵˌzoʊm/) is a large and complex molecular machine, found within all living cells, that serves as the site of biological protein synthesis (translation). Ribosomes link amino acids together in the order specified by messenger RNA (mRNA) molecules. Ribosomes consist of two major components: the small ribosomal subunit, which reads the RNA, and the large subunit, which joins amino acids to form a polypeptide chain. Each subunit is composed of one or more ribosomal RNA (rRNA) molecules and a variety of proteins. The ribosomes and associated molecules are also known as the translational apparatus.The sequence of DNA encoding for a protein may be copied many times into RNA chains of a similar sequence. Ribosomes can bind to an RNA chain and use it as a template for determining the correct sequence of amino acids in a particular protein. Amino acids are selected, collected and carried to the ribosome by transfer RNA (tRNA molecules), which enter one part of the ribosome and bind to the messenger RNA chain. The attached amino acids are then linked together by another part of the ribosome. Once the protein is produced, it can then fold to produce a specific functional three-dimensional structure.A ribosome is made from complexes of RNAs and proteins and is therefore a ribonucleoprotein. Each ribosome is divided into two subunits: 1. a smaller subunit which binds to a larger subunit and the mRNA pattern, and 2. a larger subunit which binds to the tRNA, the amino acids, and the smaller subunit. When a ribosome finishes reading an mRNA molecule, these two subunits split apart. Ribosomes are ribozymes, because the catalytic peptidyl transferase activity that links amino acids together is performed by the ribosomal RNA. Ribosomes are often embedded in the intercellular membranes that make up the rough endoplasmic reticulum.Ribosomes from bacteria, archaea and eukaryotes (the three domains of life on Earth) differ in their size, sequence, structure, and the ratio of protein to RNA. The differences in structure allow some antibiotics to kill bacteria by inhibiting their ribosomes, while leaving human ribosomes unaffected. In bacteria and archaea, more than one ribosome may move along a single mRNA chain at one time, each ""reading"" its sequence and producing a corresponding protein molecule. The ribosomes in the mitochondria of eukaryotic cells functionally resemble many features of those in bacteria, reflecting the likely evolutionary origin of mitochondria.
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