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VET-28
VET-28

... animals must not be slaughtered until the withdrawal time has been completed. Be sure to remember that the withdrawal period includes bans on offering medicated feed or water to animals before slaughter. Treatment of Disease Observing the withdrawal period is important for drugs used in treating dis ...
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... If Merck can donate $50 million in free doses of Ivermectin, what does that say about the amount of revenue the company generates in the drug research and distribution industry? In the case of Vioxx, known serious side affects were being reported and yet the company was slow to suspend or remove the ...
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... effective to slice the excess weight. However, for most, besides being too expensive, the long term uses of these drugs are marred by their severe adverse toxicities. In fact, the principal reason for drug withdrawals has been due to concerns over safety rather than the effect on body weight. For ex ...
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... It is a chemical analogue of the stimulant piperidine. With pharmacological properties similar to methylphenidate, it acts as a monoamine releasing agent with high selectivity for releasing dopamine, which may lead to addiction. It is a stimulant with a euphoric effect, which effectively boosts the ...
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... drug doses should be seen as rather conservative, especially given the number of substances for which no pharmacokinetic studies exist. It has been argued in the geriatric community29 that, because pharmacokinetic studies and dosing recommendations were established with reference to the Cockcroft-Ga ...
ANTI-INFLAMMATORY EFFECT OF THE SERRATIOPEPTIDASE
ANTI-INFLAMMATORY EFFECT OF THE SERRATIOPEPTIDASE

... There are many doubts raised about the efficacy of serratiopeptidases (11). It is marketed as orally effective antiinflammatory drug despite of its protein nature. There are many enteric coated formulations available which claim that they are not destroyed by gastric acid and get absorbed by intesti ...
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Drug interaction



A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.
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