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cells

... Columnar to squamous epithelium (most common epithelial type of metaplasia) Chronic irritation i.e. (in trachea and bronchi of smokers) Vit A deficiency squamous metaplasia in respiratory epithelium May be some loss of function May predispose to maligancy ...
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SULF1

Sulfatase 1, also known as SULF1, is an enzyme which in humans is encoded by the SULF1 gene.Heparan sulfate proteoglycans (HSPGs) act as co-receptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endo-sulfatases, such as SULF1, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules.
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