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Understanding Pediatric Cardiomyopathy
Understanding Pediatric Cardiomyopathy

... or glycogen storage diseases, both parents are unaffected carriers and have a 25 percent chance of having an affected child. Some forms of cardiomyopathy caused by Barth syndrome or Duchenne muscular dystrophy can occur sporadically in boys or may be passed on from mother to son (X-linked transmissi ...
Distribution and Structure of Purkinje Fibers in the Heart of Ostrich
Distribution and Structure of Purkinje Fibers in the Heart of Ostrich

... cells have been observed in this study to contain rounded aggregations of leptomeres. Leptomeres have previously been described by Hirako [15] who suggested that they represented an aberrant form of muscle fibril arising during development. This is unlikely since they are present in almost all Purki ...
GWAS Identifies Classical HLA Alleles Associated with Susceptibility
GWAS Identifies Classical HLA Alleles Associated with Susceptibility

... Introduction ...
Mitral Stenosis
Mitral Stenosis

... toward the remaining portions of the leaflets. Since leaflet motion is restricted mostly at the leaflet tips, the leaflets have a characteristic doming appearance in diastole (hockey stick deformity). The posterior leaflet is often times immobile. The entire mitral valvular apparatus is involved in ...
Loeffler Endocarditis_ Background, Pathophysiology
Loeffler Endocarditis_ Background, Pathophysiology

... and wall thickness may remain normal, especially early in the disease, as reported by Richardson and associates.[1, 2] Both conditions are associated with eosinophilia. The associations among eosinophilia, active carditis, and multiorgan involvement were first described by Loeffler in 1936.[3] Patho ...
Tonsillitis and Adenoids
Tonsillitis and Adenoids

... tonsillitis: Here tonsillitis is a part of generalized pharyngitis and seen in viral infections ...
Interaction between systolic and diastolic time intervals in atrial
Interaction between systolic and diastolic time intervals in atrial

... left ventricular contractile state resulting from variation in the interval between beats be shown to affect filling time at rest. The striking sensitivity of left ventricular filling time to rapid heart rate in atrial fibrillation suggests that it may be a major factor limiting cardiac performance. ...
Diagnosis and Management of Heart Failure
Diagnosis and Management of Heart Failure

... vena cava. It is a thin walled, low-pressure system, and is home to the sinoatrial (SA) node, which is the pacemaker of the heart. The right ventricle is also a thin walled, low pressure chamber that receives blood from the right atrium when the atrioventricular valve (tricuspid valve) is open. When ...
16959_JHVD_May_Antunes_3364_r1:Layout 1
16959_JHVD_May_Antunes_3364_r1:Layout 1

... Gore-Tex suture material is a linear, porous, nonabsorbent monofilament polymer, with an electronegative surface charge that mimics normal endothelium and reduces thrombogenicity (7). The long-term durability and biological adaptation of ePTFE as artificial chordae for mitral valve repair have been ...
Heart WaLL, cHambers, and VaLVes
Heart WaLL, cHambers, and VaLVes

... (Opening of the normal valve is acoustically silent.) The pressure in the atria is higher than that in the ventricles, so blood pours rapidly into the ventricles. This first passive filling phase is called early or protodiastolic filling. Toward the end of diastole, the atria contract and push the l ...
Absence of cellular responses to a putative autoantigen in
Absence of cellular responses to a putative autoantigen in

... Downloaded From: http://iovs.arvojournals.org/ on 08/11/2017 ...
Excessive vasoconstriction in rheumatic mitral stenosis with
Excessive vasoconstriction in rheumatic mitral stenosis with

... (unpublished) study of mitral stenosis that intravenous atenolol increased systemic resistance by 13%in a subgroup (n = 14)with mild to moderate pulmonary hypertension and by only 6% in a subgroup (n = 17) with severe pulmonary hypertension. It is thus unlikely that the higher systemic resistance an ...
Systolic and Diastolic Heart Failure
Systolic and Diastolic Heart Failure

... to the rest of the body; instead, it can back up into the left atrium and into the lungs, where it builds up. Left-sided heart failure causes fatigue because the body is not receiving enough blood and shortness of breath with or without exertion because of congestion in the lungs. A person may exper ...
Heart to Heart
Heart to Heart

... The heart is a fist-sized organ which lies in the centre of the chest. The right and left sides of the heart each have an upper chamber (atrium), which collects blood and lower chamber (ventricle), which ejects blood. To ensure that blood flows in only one direction, each ventricle has an inlet and ...
Heart Failure Compendium
Heart Failure Compendium

... studies of secular trends,63,66,67,70,72,73,87,88 few included outpatient data. Others used hospitalized cases without validation and are thus subject to secular changes in hospitalization practices and coding patterns, which likely confound time trends in incidence. It should not be surprising ther ...
Table 1
Table 1

... Each 1-h period preceding an AF episode was divided into four 15-min periods, and TO was analyzed for the subgroup of patients who had at least one atrial ectopic beat in each of the 15-min periods. There were 17 recordings (11 from patients with lone AF and 6 from patients with structural heart dis ...
S6 Table.
S6 Table.

... grounds to dismiss QFS as a psychiatric depressive illness. Aetiology is unclear, might be due to immune stimulation and a disordered function of the lymphocyte-macrophage interaction. Same pathways to mood change may be involved in depression and QFS and altered by chemotherapy ...
Aims - EQUIP
Aims - EQUIP

... 4. Do not prescribe an antibiotic for viral sore throat, simple coughs and colds. 5. Limit prescribing over the telephone to exceptional cases. 6. Use simple generic antibiotics first whenever possible. Avoid broad spectrum antibiotics (eg co-amoxiclav, quinolones and cephalosporins) when standard a ...
Dr. Andrew Mackie - Murmurs in Children
Dr. Andrew Mackie - Murmurs in Children

... crescendo‐decrescendo LUSB radiating to lung fields if mild, sounds similar to a pulmonary flow  murmur or ASD • however, is associated with a variable early  systolic ejection click (heard in expiration) ...
Experiment AM-6: Frog Electrocardiogram
Experiment AM-6: Frog Electrocardiogram

... Figure AM-6-B2: Diagram of a typical frog ECG with P and T, and the QRS complex identified. If the beginning of the cardiac cycle is taken as the contraction of the sinus venosus, the contraction of the various sections of the heart follows the path of the electrical signal that spreads over the hea ...
Pacemaker Development in Embryonic Rat Heart Cultured
Pacemaker Development in Embryonic Rat Heart Cultured

... somewhat against the iris. The origin of the graft impulse was located by the two electrode technique and confirmed visually. Regardless of the orientation of the tissue when grafted, the area of earliest depolarization was always near the center of the junction between the graft and iris. Mapping o ...
Patient , s Guide - Deutsches Herzzentrum München
Patient , s Guide - Deutsches Herzzentrum München

... efficiency and a conscientious environmental context. ...
Autoimmune Hepatitis Handout
Autoimmune Hepatitis Handout

... Hepatitis is the swelling of the liver. It can lead to cirrhosis (scarring of the liver), and liver failure. What is autoimmune hepatitis? Autoimmune hepatitis is a chronic (long-term) liver disease in which the immune system attacks the liver. Autoimmune hepatitis can lead to cirrhosis (scarring of ...
EHAC Course
EHAC Course

... this under a microscope and look at what is taking place. Over time plaque builds up in the areas that feed blood to the heart. When the plaque tears away or ruptures, it creates a hole. The body immediately begins to repair itself by clotting in order to heal the tear. But as the clot gets bigger a ...
Myxoma of the Left Atrium
Myxoma of the Left Atrium

... other cases of myxoma reported in the literature, and recognition of these unusual pressures may permit accurate preoperative diagnosis in other patients. Diagnostic changes may be present on apexcardiograms. ...
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Rheumatic fever



Rheumatic fever, also known as acute rheumatic fever (ARF), is an inflammatory disease that can involve the heart, joints, skin, and brain. The disease typically develops two to four weeks after a throat infection. Signs and symptoms include fever, multiple painful joints, involuntary muscle movements, and a characteristic but uncommon non itchy rash known as erythema marginatum. The heart is involved in about half of cases. Permanent damage to the heart valves, known as rheumatic heart disease (RHD), usually only occurs after multiple attacks but may occasionally occur after a single case of ARF. The damaged valves may result in heart failure. The abnormal valves also increase the risk of the person developing atrial fibrillation and infection of the valves.Acute rheumatic fever may occur following an infection of the throat by the bacteria Streptococcus pyogenes. If it is untreated ARF occurs in up to three percent of people. The underlying mechanism is believed to involve the production of antibodies against a person's own tissues. Some people due to their genetics are more likely to get the disease when exposed to the bacteria than others. Other risk factors include malnutrition and poverty. Diagnosis of ARF is often based on the presence of signs and symptoms in combination with evidence of a recent streptococcal infection.Treating people who have strep throat with antibiotics, such as penicillin, decreases their risk of getting ARF. This often involves testing people with sore throats for the infection, which may not be available in the developing world. Other preventative measures include improved sanitation. In those with ARF and RHD prolonged periods of antibiotics are sometimes recommended. Gradual return to normal activities may occur following an attack. Once RHD develops, treatment is more difficult. Occasionally valve replacement surgery or repair is required. Otherwise complications are treated as per normal.Acute rheumatic fever occurs in about 325,000 children each year and about 18 million people currently have rheumatic heart disease. Those who get ARF are most often between the ages of 5 and 14, with 20% of first-time attacks occurring in adults. The disease is most common in the developing world and among indigenous peoples in the developed world. In 2013 it resulted in 275,000 deaths down from 374,000 deaths in 1990. Most deaths occur in the developing world where as many as 12.5% of people affected may die each year. Descriptions of the condition are believed to date back to at least the 5th century BCE in the writings of Hippocrates. The disease is so named because its symptoms are similar to those of some rheumatic disorders.
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