Valvular Heart Disease in Patients with Prolactinomas on
... cabergoline (28.6%) but not in patients taking non-ergot (0%) dopamine agonists, as compared to subjects controls (5.6%). The relative risk for moderate to severe valve regurgitation in the pergolide group was 6.3 for mitral regurgitation (P=0.008), 4.2 for aortic regurgitation (P=0.01), and 5.6 for ...
... cabergoline (28.6%) but not in patients taking non-ergot (0%) dopamine agonists, as compared to subjects controls (5.6%). The relative risk for moderate to severe valve regurgitation in the pergolide group was 6.3 for mitral regurgitation (P=0.008), 4.2 for aortic regurgitation (P=0.01), and 5.6 for ...
... molecule and a receptor for high-density lipoprotein (HDL) [2, 3, 6, 7] that mediates cholesterol uptake from cells [Rigotti A. et al., Curr. Opin. Lipidol., 8:181-8, 1997; Rigotti A. et al., Proc. Nati. Acad. Sci., 94:12610-5, 1997]. SR-B 1 can also serve as a receptor for non-HDL lipoproteins and ...
PDF （582KB）
... infiltrating cells in the ocular stroma of both the cGVHD and aging mice expressed markers for oxidative stress and aging, whereas acinar cells and ductal cells barely expressed these markers (Fig. 1). Given that the greatest accumulation of the products of oxidative damage was found in infiltrating ...
... infiltrating cells in the ocular stroma of both the cGVHD and aging mice expressed markers for oxidative stress and aging, whereas acinar cells and ductal cells barely expressed these markers (Fig. 1). Given that the greatest accumulation of the products of oxidative damage was found in infiltrating ...
Review Immunoglobulins in Defense, Pathogenesis, and Therapy of Fungal Diseases
... in host defense against fungi, and they have brought about a paradigm shift in our thinking on this question. Prior to the 1990s, AMI was considered to be irrelevant in host defense against fungi (for review, see Casadevall, 1995), as the experimental methods that were in use at the time were not ab ...
... in host defense against fungi, and they have brought about a paradigm shift in our thinking on this question. Prior to the 1990s, AMI was considered to be irrelevant in host defense against fungi (for review, see Casadevall, 1995), as the experimental methods that were in use at the time were not ab ...
Endocardial endothelium in the avascular frog heart - AJP
... 2003.—We investigated the role of nitric oxide (NO) in the control of myocardial O2 consumption in the hearts of female Xenopus frogs, which lack a coronary vascular endothelium and in which the endocardial endothelium is the only source of NO to regulate cardiac myocyte function. Hence, frogs are a ...
... 2003.—We investigated the role of nitric oxide (NO) in the control of myocardial O2 consumption in the hearts of female Xenopus frogs, which lack a coronary vascular endothelium and in which the endocardial endothelium is the only source of NO to regulate cardiac myocyte function. Hence, frogs are a ...
Heart Rate Variability from Short Electrocardiographic Recordings
... the possible mechanisms underlying this association. Furthermore, in the elderly, heart rate variability is generally lower than in younger subjects (11). Because the importance of heart rate variability was not known until recently, no long-term follow-up studies in younger populations are availabl ...
... the possible mechanisms underlying this association. Furthermore, in the elderly, heart rate variability is generally lower than in younger subjects (11). Because the importance of heart rate variability was not known until recently, no long-term follow-up studies in younger populations are availabl ...
Congenital heart disease fact sheet
... Total anomalous pul venous return Eisenmeger’s syndrome (large uncorrected ASD / VSD; occurs later as infant / child) Other: persistent fetal circulation (caused by structural heart disease, meconium aspiration, pneumonia, sepsis, pul HTN) blood shunts RL through PFO / ASD / VSD Sx: effortless in ...
... Total anomalous pul venous return Eisenmeger’s syndrome (large uncorrected ASD / VSD; occurs later as infant / child) Other: persistent fetal circulation (caused by structural heart disease, meconium aspiration, pneumonia, sepsis, pul HTN) blood shunts RL through PFO / ASD / VSD Sx: effortless in ...
The heart rate story
... giant scale depicted in this painting, the heart is put into a vessel. On the left side stands Ma’at with a feather. If the heart weighs more (hypertrophy), the monkey sitting on the top of the scale eats the heart and the soul does not reach eternity. Alternatively, if the heart weighs less, the de ...
... giant scale depicted in this painting, the heart is put into a vessel. On the left side stands Ma’at with a feather. If the heart weighs more (hypertrophy), the monkey sitting on the top of the scale eats the heart and the soul does not reach eternity. Alternatively, if the heart weighs less, the de ...
Physical Examination of the Cardiovascular System
... afterload, chamber dimensions, and pressure gradients will have specific and predictable effects on true pathological murmurs [5]. Another important aspect of helping to distinguish pathological murmurs is their sound distribution on the chest wall. A recent study noted that when diagnosing systol ...
... afterload, chamber dimensions, and pressure gradients will have specific and predictable effects on true pathological murmurs [5]. Another important aspect of helping to distinguish pathological murmurs is their sound distribution on the chest wall. A recent study noted that when diagnosing systol ...
Impetigo - Boston Health Care for the Homeless Program
... Impetigo spreads easily and most commonly by direct contact to infected skin. Infection may also spread through contaminated clothing. People who begin treatment with topical or oral antibiotics are no longer infectious after 24 to 48 hours. Breakdowns in skin integrity, such as cuts, scratched inse ...
... Impetigo spreads easily and most commonly by direct contact to infected skin. Infection may also spread through contaminated clothing. People who begin treatment with topical or oral antibiotics are no longer infectious after 24 to 48 hours. Breakdowns in skin integrity, such as cuts, scratched inse ...
Inter-ventricular septum: New observations on the structure and
... In order to better visualize the histology of the interventricular septum, we decided not to use electron microscopic analysis, which requires chemical fixation that tends to cause some distortion of the tissues. As already observed by other investigators [2,50,51], because of the changes induced by ...
... In order to better visualize the histology of the interventricular septum, we decided not to use electron microscopic analysis, which requires chemical fixation that tends to cause some distortion of the tissues. As already observed by other investigators [2,50,51], because of the changes induced by ...
Full Text - Digital Access to Scholarship at Harvard
... 2010) and L-type Ca2+ channels (ICa,L; Petit-Jacques et al., 1993; Zaza et al., 1996; Mangoni and Nargeot, 2008), as well as ryanodine receptor–mediated Ca2+ release (Lakatta et al., 2010). All of these ionic mechanisms are thus potentially involved in the cholinergic regulation © 2013 Mesirca et al ...
... 2010) and L-type Ca2+ channels (ICa,L; Petit-Jacques et al., 1993; Zaza et al., 1996; Mangoni and Nargeot, 2008), as well as ryanodine receptor–mediated Ca2+ release (Lakatta et al., 2010). All of these ionic mechanisms are thus potentially involved in the cholinergic regulation © 2013 Mesirca et al ...
Vascular Pathophysiology in Response to Increased Heart Rate
... Endothelial dysfunction and increased heart rate. Because of its exposed location at the inner vessel wall, the endothelial monolayer acts as a mechanosensitive gatekeeper and a signal transduction interface for hemodynamic forces. These forces determine the shape and function of endothelial cells, ...
... Endothelial dysfunction and increased heart rate. Because of its exposed location at the inner vessel wall, the endothelial monolayer acts as a mechanosensitive gatekeeper and a signal transduction interface for hemodynamic forces. These forces determine the shape and function of endothelial cells, ...
Living with Heart Failure - Montefiore Medical Center
... The left upper and lower chambers supply oxygen-rich blood to the tissues in the body. With each heartbeat, a normal left ventricle pumps out or “ejects” 55 – 60% of the blood it receives. This is called the “ejection fraction” or EF. In heart failure, the heart pumps less blood with each beat, so t ...
... The left upper and lower chambers supply oxygen-rich blood to the tissues in the body. With each heartbeat, a normal left ventricle pumps out or “ejects” 55 – 60% of the blood it receives. This is called the “ejection fraction” or EF. In heart failure, the heart pumps less blood with each beat, so t ...
a Patient`s Guide to Transcatheter Aortic
... Aortic Stenosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Treatment Options for Your Severe Aortic Stenosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Treatment of Your Severe Aortic Stenos ...
... Aortic Stenosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Treatment Options for Your Severe Aortic Stenosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Treatment of Your Severe Aortic Stenos ...
Slide 1
... • Steroids are important risk factors for IA • Steroid-induced changes in immunobiology of ...
... • Steroids are important risk factors for IA • Steroid-induced changes in immunobiology of ...
Ferrari_ nature
... therefore, long-term -blockade in the setting of HF exerts positive inotropism, despite the wellknown negative inotropic action of this class of drugs38,39. Whether this effect is the result of heart rate reduction, or other actions mediated by -adrenergic receptor blockade such as prevention of t ...
... therefore, long-term -blockade in the setting of HF exerts positive inotropism, despite the wellknown negative inotropic action of this class of drugs38,39. Whether this effect is the result of heart rate reduction, or other actions mediated by -adrenergic receptor blockade such as prevention of t ...
Targeting Reactive Oxygen Species Production To Prevent Left
... not well understood and currently, no medical therapy exists to treat this condition. Cardiac VO is marked by eccentric remodeling and contractile dysfunction ultimately resulting in cardiac failure. Oxidative stress is implicated in the pathophysiology of heart failure and recent evidence suggests ...
... not well understood and currently, no medical therapy exists to treat this condition. Cardiac VO is marked by eccentric remodeling and contractile dysfunction ultimately resulting in cardiac failure. Oxidative stress is implicated in the pathophysiology of heart failure and recent evidence suggests ...
Myocardium 2013
... associated cardiac involvement. Corynebacterium diphtheriae Traditionally considered a myocarditis, injury to the myocardium by the potent exotoxin of the bacterium Corynebacterium diphtheriae is characterized by patchy myocyte necrosis with only a sparse lymphocytic infiltrate. Myocardium ...
... associated cardiac involvement. Corynebacterium diphtheriae Traditionally considered a myocarditis, injury to the myocardium by the potent exotoxin of the bacterium Corynebacterium diphtheriae is characterized by patchy myocyte necrosis with only a sparse lymphocytic infiltrate. Myocardium ...
12-Development_of_Heart
... Develop as swellings arising from localized proliferations of tissue: 1. Around AV canals (AV valves) 2. Around orifices of aorta & pulmonary trunk (semilunar valves) • Swellings are hollowed out & reshaped to form the cusps ...
... Develop as swellings arising from localized proliferations of tissue: 1. Around AV canals (AV valves) 2. Around orifices of aorta & pulmonary trunk (semilunar valves) • Swellings are hollowed out & reshaped to form the cusps ...
Cardiac Pacemakers From the Patient`s Perspective
... about 1% to 2%. Usually only a small bump in the skin is seen over the place where the pacemaker has been implanted. Other than restrictions on heavy lifting and extreme motion of the arm on the side of the pacemaker for several weeks, recovery from the procedure is minimal. Most patients return to ...
... about 1% to 2%. Usually only a small bump in the skin is seen over the place where the pacemaker has been implanted. Other than restrictions on heavy lifting and extreme motion of the arm on the side of the pacemaker for several weeks, recovery from the procedure is minimal. Most patients return to ...
Mucosal inflammation in idiopathic bronchiectasis: cellular and molecular mechanisms REVIEW
... response. Therefore, it has been suggested that a nonclearing adaptive immune response to chronic infection of the lower respiratory tract in bronchiectasis subjects contributes to the airway inflammatory process [27]. Recently, it has been reported in vivo that NHTi form adherent biofilms on the ap ...
... response. Therefore, it has been suggested that a nonclearing adaptive immune response to chronic infection of the lower respiratory tract in bronchiectasis subjects contributes to the airway inflammatory process [27]. Recently, it has been reported in vivo that NHTi form adherent biofilms on the ap ...
Genetic background affects susceptibility in nonfatal pneumococcal bronchopneumonia J.A. Preston , K.W. Beagley
... Health, University of Newcastle, }Respiratory and Sleep Medicine, Hunter Medical Research Institute, and School of Medical Practice, John Hunter Hospital, Newcastle, and #Vaccines, Immunity/Infection, Viruses and Asthma Group, Hunter Medical Research Institute, New Lambton, New South Wales, Australi ...
... Health, University of Newcastle, }Respiratory and Sleep Medicine, Hunter Medical Research Institute, and School of Medical Practice, John Hunter Hospital, Newcastle, and #Vaccines, Immunity/Infection, Viruses and Asthma Group, Hunter Medical Research Institute, New Lambton, New South Wales, Australi ...
Rheumatic fever
Rheumatic fever, also known as acute rheumatic fever (ARF), is an inflammatory disease that can involve the heart, joints, skin, and brain. The disease typically develops two to four weeks after a throat infection. Signs and symptoms include fever, multiple painful joints, involuntary muscle movements, and a characteristic but uncommon non itchy rash known as erythema marginatum. The heart is involved in about half of cases. Permanent damage to the heart valves, known as rheumatic heart disease (RHD), usually only occurs after multiple attacks but may occasionally occur after a single case of ARF. The damaged valves may result in heart failure. The abnormal valves also increase the risk of the person developing atrial fibrillation and infection of the valves.Acute rheumatic fever may occur following an infection of the throat by the bacteria Streptococcus pyogenes. If it is untreated ARF occurs in up to three percent of people. The underlying mechanism is believed to involve the production of antibodies against a person's own tissues. Some people due to their genetics are more likely to get the disease when exposed to the bacteria than others. Other risk factors include malnutrition and poverty. Diagnosis of ARF is often based on the presence of signs and symptoms in combination with evidence of a recent streptococcal infection.Treating people who have strep throat with antibiotics, such as penicillin, decreases their risk of getting ARF. This often involves testing people with sore throats for the infection, which may not be available in the developing world. Other preventative measures include improved sanitation. In those with ARF and RHD prolonged periods of antibiotics are sometimes recommended. Gradual return to normal activities may occur following an attack. Once RHD develops, treatment is more difficult. Occasionally valve replacement surgery or repair is required. Otherwise complications are treated as per normal.Acute rheumatic fever occurs in about 325,000 children each year and about 18 million people currently have rheumatic heart disease. Those who get ARF are most often between the ages of 5 and 14, with 20% of first-time attacks occurring in adults. The disease is most common in the developing world and among indigenous peoples in the developed world. In 2013 it resulted in 275,000 deaths down from 374,000 deaths in 1990. Most deaths occur in the developing world where as many as 12.5% of people affected may die each year. Descriptions of the condition are believed to date back to at least the 5th century BCE in the writings of Hippocrates. The disease is so named because its symptoms are similar to those of some rheumatic disorders.