Long-lived plasma cells: a mechanism for maintaining persistent
... distinguish between antibody production by pre-existing host cells (IgH a) and by donor cells (IgH b) by allotype-specific ELISA and ELISPOT. Although the irradiated mice became fully reconstituted with donor B lymphocytes, no donor-derived virus-specific serum antibody production was observed. This ...
... distinguish between antibody production by pre-existing host cells (IgH a) and by donor cells (IgH b) by allotype-specific ELISA and ELISPOT. Although the irradiated mice became fully reconstituted with donor B lymphocytes, no donor-derived virus-specific serum antibody production was observed. This ...
PDF
... cells (pDCs), single stranded viral RNA is exposed by viral capsid degradation in the acidified endosomes for detection by TLR7. The production of pro-inflammatory cytokines and type I interferons are induced through the RIG I and TLR7 pathways. IRF7 (interferon regulatory factor 7) and NF-kB are ac ...
... cells (pDCs), single stranded viral RNA is exposed by viral capsid degradation in the acidified endosomes for detection by TLR7. The production of pro-inflammatory cytokines and type I interferons are induced through the RIG I and TLR7 pathways. IRF7 (interferon regulatory factor 7) and NF-kB are ac ...
Foundations I Schedule 2015
... Foundations I Schedule Course Overview The objective of this course is to familiarize learners with core concepts in immunology, microbiology, and virology. Accordingly, the course is divided into 10 weeklong sessions in which a core component of mammalian immunity is introduced, followed by an exam ...
... Foundations I Schedule Course Overview The objective of this course is to familiarize learners with core concepts in immunology, microbiology, and virology. Accordingly, the course is divided into 10 weeklong sessions in which a core component of mammalian immunity is introduced, followed by an exam ...
Cells in Gut-Oriented Immune Responses The Role of Dendritic
... nization with the original fed Ag (17). Both the transferable suppression and the bystander effect have been associated with Th3 cells producing TGF-, as well as with Th2 cells that produce IL-4 and IL-10 (18), although subsequent high-dose feeding may change these characteristics (19). Thus, the r ...
... nization with the original fed Ag (17). Both the transferable suppression and the bystander effect have been associated with Th3 cells producing TGF-, as well as with Th2 cells that produce IL-4 and IL-10 (18), although subsequent high-dose feeding may change these characteristics (19). Thus, the r ...
Recognition of measles virus-infected cells by CD8MT cells
... retained in the cell as a result of MV infection. Staining with the Kk-specific MAb 11-4.1 and subsequent analysis by flow cytometry indicated that MV-infected cells expressed more Kk than non-infected cells (Fig. 1 a). In addition, MV-infected cells could be rendered susceptible to lysis by additio ...
... retained in the cell as a result of MV infection. Staining with the Kk-specific MAb 11-4.1 and subsequent analysis by flow cytometry indicated that MV-infected cells expressed more Kk than non-infected cells (Fig. 1 a). In addition, MV-infected cells could be rendered susceptible to lysis by additio ...
The role of polyunsaturated fatty acids in immune function
... Efforts are underway to determine if changes in the amount of dietary polyunsaturated fatty acids (PUFA) effect the immune response and progression of mycobacteriosis in striped bass. The current study, conducted at the NOAA Cooperative Oxford Laboratory, seeks to elucidate the underlying mechanisms ...
... Efforts are underway to determine if changes in the amount of dietary polyunsaturated fatty acids (PUFA) effect the immune response and progression of mycobacteriosis in striped bass. The current study, conducted at the NOAA Cooperative Oxford Laboratory, seeks to elucidate the underlying mechanisms ...
Melatonin protects against experimental immune ovarian failure in
... Several ovarian disorders in women including premature ovarian failure [8, 17, 18], polycystic ovary syndrome (in which immunological disturbances may be secondary; [8, 20]), some types of oophoritis [20] or unexplained infertility [8, 17] are associated with autoimmune factors. They have been repor ...
... Several ovarian disorders in women including premature ovarian failure [8, 17, 18], polycystic ovary syndrome (in which immunological disturbances may be secondary; [8, 20]), some types of oophoritis [20] or unexplained infertility [8, 17] are associated with autoimmune factors. They have been repor ...
How pregnancy can affect autoimmune diseases progression
... excessive tissue damage [45]. Recently, it has been suggested that Th17 cells that have shifted towards Th1-phenotype seem to be more aggressive and more pathogenic than Th17 unshifted cells particularly in inflammatory diseases as MS, RA, psoriasis or inflammatory bowel diseases. Nonetheless, IL-17 ...
... excessive tissue damage [45]. Recently, it has been suggested that Th17 cells that have shifted towards Th1-phenotype seem to be more aggressive and more pathogenic than Th17 unshifted cells particularly in inflammatory diseases as MS, RA, psoriasis or inflammatory bowel diseases. Nonetheless, IL-17 ...
Placental regulation of maternal-fetal interactions and
... It is clear that the molecular mechanisms regulating normal placental functions are tightly intertwined, governed by both cells at the maternal–fetal interface and soluble factors in the local microenvironment. Signaling of cytokines, growth factors and hormones are central to the cross-talk between ...
... It is clear that the molecular mechanisms regulating normal placental functions are tightly intertwined, governed by both cells at the maternal–fetal interface and soluble factors in the local microenvironment. Signaling of cytokines, growth factors and hormones are central to the cross-talk between ...
The role of glucose and lipid metabolism in the
... The cellular growth, function, and survival of activated T cells depend on a dramatic increase in glucose metabolism to provide cellular fuel. This augmented glucose metabolism is highly regulated and has a profound impact on a sustained antiviral response. Thus, impaired glucose metabolism in T cel ...
... The cellular growth, function, and survival of activated T cells depend on a dramatic increase in glucose metabolism to provide cellular fuel. This augmented glucose metabolism is highly regulated and has a profound impact on a sustained antiviral response. Thus, impaired glucose metabolism in T cel ...
Evidence for specific immune response against P210 BCR
... CML is a pluripotent stem cell disease that primarily affects myeloid lineages in chronic phase. The disease almost always progresses to the blast crisis stage, which is the terminal stage. Therapy of CML with interferon (IFN) is associated with frequent hematopoietic remissions and complete cytogen ...
... CML is a pluripotent stem cell disease that primarily affects myeloid lineages in chronic phase. The disease almost always progresses to the blast crisis stage, which is the terminal stage. Therapy of CML with interferon (IFN) is associated with frequent hematopoietic remissions and complete cytogen ...
Cells - HAL
... can take up antigenic material from live or dead cells [7, 8], either apoptotic or necrotic. It has also been shown that antigens associated with immune complexes [9, 10] or opsonized cells [11, 12] are efficiently cross-presented by dendritic cells and can be used to generate antitumor cytotoxic T ...
... can take up antigenic material from live or dead cells [7, 8], either apoptotic or necrotic. It has also been shown that antigens associated with immune complexes [9, 10] or opsonized cells [11, 12] are efficiently cross-presented by dendritic cells and can be used to generate antitumor cytotoxic T ...
The Science of HIV Vaccines
... more details.) Cell-mediated immunity refers to T cells, most importantly CD8+ and CD4+ T cells. These terms are important in vaccine science since different vaccines induce relatively different responses from the two arms of the immune system. Antibodies effectively stop virus particles (or other i ...
... more details.) Cell-mediated immunity refers to T cells, most importantly CD8+ and CD4+ T cells. These terms are important in vaccine science since different vaccines induce relatively different responses from the two arms of the immune system. Antibodies effectively stop virus particles (or other i ...
BIO INSPIRED COMPUTING In
... context are referred to as phenotypes, their encoding, the individuals within the EA, are called genotypes. The first design step is commonly called representation, as it amounts to specifying a mapping from the phenotypes onto a set of genotypes that are said to represent these phenotypes. For insta ...
... context are referred to as phenotypes, their encoding, the individuals within the EA, are called genotypes. The first design step is commonly called representation, as it amounts to specifying a mapping from the phenotypes onto a set of genotypes that are said to represent these phenotypes. For insta ...
Gene Expression Measurement of Immuno
... A homophilic binding glycoprotein expressed on the surface of neurons, glia, skeletal muscle and natural killer cells ...
... A homophilic binding glycoprotein expressed on the surface of neurons, glia, skeletal muscle and natural killer cells ...
Klin immunology_1
... lymph nodes B. They carry membrane-bound IgD on their surface C. They constitute 70 to 80 percent of circulating blood lymphocytes D. They arise from stem cells in the thymus E. They are the main effectors of antibodydependent, cell-mediated cytotoxicity ANSWER: C 11. Human immunoglobulin A (IgA) ca ...
... lymph nodes B. They carry membrane-bound IgD on their surface C. They constitute 70 to 80 percent of circulating blood lymphocytes D. They arise from stem cells in the thymus E. They are the main effectors of antibodydependent, cell-mediated cytotoxicity ANSWER: C 11. Human immunoglobulin A (IgA) ca ...
march_22_lecture
... It was a normal mid-January afternoon in Nome. Doctor Curtis Welch, physician and director of the US Public Health Service, was doing paperwork in his office at the Merchants and Miners Bank of Alaska building. An Innuit man came into the office asking the doctor to come quickly, his two children we ...
... It was a normal mid-January afternoon in Nome. Doctor Curtis Welch, physician and director of the US Public Health Service, was doing paperwork in his office at the Merchants and Miners Bank of Alaska building. An Innuit man came into the office asking the doctor to come quickly, his two children we ...
deficiency
... highly underrepresented. Hence, genes involved in genetic diseases are not simply a random subset of all genes in the genome, but are biased towards ancient genes. ...
... highly underrepresented. Hence, genes involved in genetic diseases are not simply a random subset of all genes in the genome, but are biased towards ancient genes. ...
vaccines
... plasmid-encoded agonist of innate immune receptors to activate a large variety of molecules capable of promoting adaptive immunity, unlike many other approaches which use single cytokines or chemokines [3]. A major benefit of this system is that it works without physically linking the antigen to fla ...
... plasmid-encoded agonist of innate immune receptors to activate a large variety of molecules capable of promoting adaptive immunity, unlike many other approaches which use single cytokines or chemokines [3]. A major benefit of this system is that it works without physically linking the antigen to fla ...
Neisseria gonorrhoeae Variation of Lipooligosaccharide Directs Dendritic Cell–Induced T Helper Responses
... DCs. DCs do express the GalNAc-specific C-type lectin MGL [25]. We hypothesized that this lectin might be the major receptor for GC phenotype C. A fusion protein of the extracellular domains of MGL coupled to the human IgG1 Fc tail strongly recognized GC variant C in a dose-dependent manner in an EL ...
... DCs. DCs do express the GalNAc-specific C-type lectin MGL [25]. We hypothesized that this lectin might be the major receptor for GC phenotype C. A fusion protein of the extracellular domains of MGL coupled to the human IgG1 Fc tail strongly recognized GC variant C in a dose-dependent manner in an EL ...
PDF only - at www.arxiv.org.
... Adaptive immunity is one of the marvels of Biology and one of its greatest mysteries. Organisms have to respond to novel antigens which they have not seen before and this response should be specific in order to avoid attacking its own proteins (autoimmunity). This task represents a clear example of ...
... Adaptive immunity is one of the marvels of Biology and one of its greatest mysteries. Organisms have to respond to novel antigens which they have not seen before and this response should be specific in order to avoid attacking its own proteins (autoimmunity). This task represents a clear example of ...
ILO`s and lecture objectives-HMIM 224(2013
... Explain factors affecting absorption of iron from GIT. Discuss iron distribution and excretion in the body. Recognize laboratory assessment investigations for iron status. Understand causes of iron deficiencies and iron overload with reference to clinical consequences. ...
... Explain factors affecting absorption of iron from GIT. Discuss iron distribution and excretion in the body. Recognize laboratory assessment investigations for iron status. Understand causes of iron deficiencies and iron overload with reference to clinical consequences. ...
Immune system
The immune system is a system of many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. In many species, the immune system can be classified into subsystems, such as the innate immune system versus the adaptive immune system, or humoral immunity versus cell-mediated immunity.Pathogens can rapidly evolve and adapt, and thereby avoid detection and neutralization by the immune system; however, multiple defense mechanisms have also evolved to recognize and neutralize pathogens. Even simple unicellular organisms such as bacteria possess a rudimentary immune system, in the form of enzymes that protect against bacteriophage infections. Other basic immune mechanisms evolved in ancient eukaryotes and remain in their modern descendants, such as plants and insects. These mechanisms include phagocytosis, antimicrobial peptides called defensins, and the complement system. Jawed vertebrates, including humans, have even more sophisticated defense mechanisms, including the ability to adapt over time to recognize specific pathogens more efficiently. Adaptive (or acquired) immunity creates immunological memory after an initial response to a specific pathogen, leading to an enhanced response to subsequent encounters with that same pathogen. This process of acquired immunity is the basis of vaccination.Disorders of the immune system can result in autoimmune diseases, inflammatory diseases and cancer.Immunodeficiency occurs when the immune system is less active than normal, resulting in recurring and life-threatening infections. In humans, immunodeficiency can either be the result of a genetic disease such as severe combined immunodeficiency, acquired conditions such as HIV/AIDS, or the use of immunosuppressive medication. In contrast, autoimmunity results from a hyperactive immune system attacking normal tissues as if they were foreign organisms. Common autoimmune diseases include Hashimoto's thyroiditis, rheumatoid arthritis, diabetes mellitus type 1, and systemic lupus erythematosus. Immunology covers the study of all aspects of the immune system.