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An investigation of the mechanism of destruction by mammalian
An investigation of the mechanism of destruction by mammalian

... An investigation of the mechanism of destruction by mammalian immune cells of azidelabeled Helicobacter pylori Jennifer Helble, class of 2014 Helicobacter pylori is a Gram-negative bacterial species that colonizes the gastric tract of over 50% of the world’s population and is one of the leading caus ...
regulation of the immune response
regulation of the immune response

... For induction of TH cells, TH cells recognize antigen in association with class II molecules. Cytotoxic T cells recognize viral antigens in association with class I molecules. This recognition of MHC was learnt during ontogeny. ...
Study Guide - Communicable Diseases, Ch
Study Guide - Communicable Diseases, Ch

... (If pathogens break through the body’s outermost barriers, our body then goes into “red alert.” Increased blood flow allows the phagocytes to continue to enter the infected body tissue until the pathogens are destroyed.) ...
Immunology and Cancer
Immunology and Cancer

... Antibody and complement Lymphokines and other cytokines Cell-Mediated Immunity: Cytotoxic T-Cells Natural Killer Cells (NK Cells) Activated Killer Cells Activated macrophages Lymphokine-activated Lymphocytes Granulocytes Combined Humoral and Cell-mediated: Antibody-dependent Cell-mediated Cytotoxici ...
Document
Document

... PRRs are differentially expressed on a wide variety of immune cells, including neutrophils, macrophages, dendritic cells, natural killer cells, B cells and in some nonimmune cells too, such as epithelial and endothelial cells. Engagement of PRRs leads to the activation of some of these cells and sec ...
Immune System and Disease
Immune System and Disease

... Nonspecific Defenses The body has many nonspecific defenses, which defend against a wide range of pathogens. ▶ The first line of defense is skin. Skin keeps pathogens out of the body by forming a barrier that few pathogens can get through. Mucus, saliva, and tears contain an enzyme that can kill bac ...
L S B D
L S B D

...  Slightly different biological roles  Antibodies can function through: ...
AUTOIMMUNE DISEASES
AUTOIMMUNE DISEASES

... expressing self-MHC-I + self-peptide complexes, and attack non-self (altered) complexes. Normally, altered complexes would be the result of infection or transformation of the cell expressing the MHC, that is, the peptide will be non-self. However, transplantation of tissues from a non-MHC-matched do ...
Cytokine - Chemotaxis Group
Cytokine - Chemotaxis Group

... ! 10 IL-1 molecules are enough to induce IL-2 synthesis in T cells ! ! 50 IFN gamma molecules are enough to induce anti-viral effects ! ...
投影片 1
投影片 1

... -Production and secretion of antibody into circulatory system -The antibody/antigen complex are ingested and destroyed by a special class of white blood cells ...
Cytokine - Chemotaxis Group
Cytokine - Chemotaxis Group

... ! 10 IL-1 molecules are enough to induce IL-2 synthesis in T cells ! ! 50 IFN gamma molecules are enough to induce anti-viral effects ! ...
Vaccination ppt
Vaccination ppt

... • Adaptive immunity may be classified based on the host’s role in developing the adaptive specific immunity.  Active immunity is generated when an immunocompetent host is exposed to the foreign challenge and the host’s native immune cells respond by generating specific immune products.  Passive im ...
DEFINITIONS - Microbiology Book
DEFINITIONS - Microbiology Book

... Antigenic Determinants Recognized by T cells • Composition – Proteins (some lipids) – Sequence determinants • Processed • MHC presentation (lipid presentation by MHC-like CD1) ...
Clinical Signs are an Interaction of Host, Agent and the Environment
Clinical Signs are an Interaction of Host, Agent and the Environment

Human Immune Responses
Human Immune Responses

... • Class 1 markers are on the membranes of all nucleated cells (not RBCs) • Class 2 markers are on membranes of B cells, T cells and some macrophages. ...
Lecture 14-Carbohydrate recognition in cell adhesion and signalling
Lecture 14-Carbohydrate recognition in cell adhesion and signalling

Immune Disorders Allergies 4 Hypersensitivity Types
Immune Disorders Allergies 4 Hypersensitivity Types

... • Live donors – skin, liver, kidney, bone marrow • Fetal donors – pancreas, brain tissue • Cadaver donors – heart, kidney, cornea • Stem cells – bone marrow, blood, umbilical cord ...
fighting disease
fighting disease

... lymphatic system Lymphatic vessels circulate lymph, a fluid that contains lymphocytes (white blood cells) Bacteria are collected by the lymph and filtered out through lymph organs Bone marrow produces macrophages, special white blood cells that engulf and destroy bacteria Pus is dead white blood cel ...
Document
Document

... The cell is the most basic unit of life, performing all of the functions necessary for life. In the eukaryotic vertebrate cell these functions are performed by various organelles within the cell. The cell membrane plays a role in the dynamic process of molecular movement in and out of the cell. At ...
Immunology PPT - Old Saybrook Public Schools
Immunology PPT - Old Saybrook Public Schools

... • consists of innate immunity and acquired (adaptive) immunity ...
Immunological Defence Mechanisms Against Biological
Immunological Defence Mechanisms Against Biological

... Very virulent germs tend to disappear in nature, because they kill their sensitive hosts (natural selection): the killer disappears together with the killed. However, many virulent germs tend in time to attenuate their aggressiveness (which might make them extinguish), allowing milder forms of infec ...
1 week
1 week

... • Principle function is to return fluid, plasma proteins, lymphocytes, and immunoglobins back to circulation • Picks up extracellular fluid from tissues and returns it to the circulatory system ...
Cells of the immune system
Cells of the immune system

... mechanisms. They also help to activate T cells (connection between innate and adaptive immunity) NK cells are lymphocytes that have characteristics of innate and adaptive immunity. ...
Role of Advanced Clinical Immuno-nutrition in Hospitalized Patients
Role of Advanced Clinical Immuno-nutrition in Hospitalized Patients

... A high proportion of patients in hospital are malnourished and that malnourishment impairs immune function.  The capacity for nutrients to modulate the actions of the immune system and, to affect clinical outcome has thus become an important issue in clinical practice. ...
Document
Document

... Any time this antigen re-enters the body, these clones are formed to destroy it Role of MEMORY cells, both T and B Are not associated with the initial response to antigen They “REMEMBER” when an antigen enters body again, and act by initiating formation of more clones of that type of lymphocyte They ...
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Immune system



The immune system is a system of many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. In many species, the immune system can be classified into subsystems, such as the innate immune system versus the adaptive immune system, or humoral immunity versus cell-mediated immunity.Pathogens can rapidly evolve and adapt, and thereby avoid detection and neutralization by the immune system; however, multiple defense mechanisms have also evolved to recognize and neutralize pathogens. Even simple unicellular organisms such as bacteria possess a rudimentary immune system, in the form of enzymes that protect against bacteriophage infections. Other basic immune mechanisms evolved in ancient eukaryotes and remain in their modern descendants, such as plants and insects. These mechanisms include phagocytosis, antimicrobial peptides called defensins, and the complement system. Jawed vertebrates, including humans, have even more sophisticated defense mechanisms, including the ability to adapt over time to recognize specific pathogens more efficiently. Adaptive (or acquired) immunity creates immunological memory after an initial response to a specific pathogen, leading to an enhanced response to subsequent encounters with that same pathogen. This process of acquired immunity is the basis of vaccination.Disorders of the immune system can result in autoimmune diseases, inflammatory diseases and cancer.Immunodeficiency occurs when the immune system is less active than normal, resulting in recurring and life-threatening infections. In humans, immunodeficiency can either be the result of a genetic disease such as severe combined immunodeficiency, acquired conditions such as HIV/AIDS, or the use of immunosuppressive medication. In contrast, autoimmunity results from a hyperactive immune system attacking normal tissues as if they were foreign organisms. Common autoimmune diseases include Hashimoto's thyroiditis, rheumatoid arthritis, diabetes mellitus type 1, and systemic lupus erythematosus. Immunology covers the study of all aspects of the immune system.
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