The normal cellular prion protein is strongly expressed by myeloid
... (PrPSc) that cause prion diseases are propagated and spread within the body by “carrier” cell(s). Cells of the immune system have been strongly implicated in this process. In particular, PrPSc is known to accumulate on follicular dendritic cells (FDCs) in individuals affected by variant Creutzfeld-J ...
... (PrPSc) that cause prion diseases are propagated and spread within the body by “carrier” cell(s). Cells of the immune system have been strongly implicated in this process. In particular, PrPSc is known to accumulate on follicular dendritic cells (FDCs) in individuals affected by variant Creutzfeld-J ...
Dectin 1
... 1. Specific delivery of antigens to DCs (e.g. on Ag-covered particles). This approach was proved to work, but remains expensive and difficult. 2. Targeting DEC205, DC-SIGN or mannose receptor by antibodies induces CD4+ and CD8+ cells responses. This can be used to induce tolerance to pancreatic β-ce ...
... 1. Specific delivery of antigens to DCs (e.g. on Ag-covered particles). This approach was proved to work, but remains expensive and difficult. 2. Targeting DEC205, DC-SIGN or mannose receptor by antibodies induces CD4+ and CD8+ cells responses. This can be used to induce tolerance to pancreatic β-ce ...
Bovine Respiratory Disease Complex and Designing Effective
... – Avoid co-mingling cattle from different sources during critical 3-week period – Keep new cattle close to feed and water – Don’t over crowd (especially early in feeding period) – Control dust and mud ...
... – Avoid co-mingling cattle from different sources during critical 3-week period – Keep new cattle close to feed and water – Don’t over crowd (especially early in feeding period) – Control dust and mud ...
Differential expression of surface membrane Trypanosoma congolense
... relatively inactive and non-dividing except when stimulated to proliferate and show increases in size and activities when stimulated by various types of Accepted for publication 5 October 2000-Editor ...
... relatively inactive and non-dividing except when stimulated to proliferate and show increases in size and activities when stimulated by various types of Accepted for publication 5 October 2000-Editor ...
Lesson 64. Auto Immunity and auto immune diseases
... defends the body against infections and certain other diseases by identifying, attacking, and destroying germs and other foreign substances. Sometimes the immune system makes a mistake and starts attacking the body’s own tissues or organs. This is called autoimmunity. There are many autoimmune disea ...
... defends the body against infections and certain other diseases by identifying, attacking, and destroying germs and other foreign substances. Sometimes the immune system makes a mistake and starts attacking the body’s own tissues or organs. This is called autoimmunity. There are many autoimmune disea ...
Chlamydia
... one of the mechanisms C. trachomatis-infected cells use to evade an immune response involving recognition and destruction by cytotoxic T lymphocytes (Zhong et al., 2000). However, the downregulation of MHC class I leads to activation of natural killer (NK) cells because of a decreasing inhibitory si ...
... one of the mechanisms C. trachomatis-infected cells use to evade an immune response involving recognition and destruction by cytotoxic T lymphocytes (Zhong et al., 2000). However, the downregulation of MHC class I leads to activation of natural killer (NK) cells because of a decreasing inhibitory si ...
Program outline
... bridges the knowledge of the infectious agents per se with that of the host response, the susceptibility to infection, and infection-associated immunopathology. Primary objectives are identification of (i) innate sensing receptors for pathogens in different hosts (pigs, chicken, bovine, human, mouse ...
... bridges the knowledge of the infectious agents per se with that of the host response, the susceptibility to infection, and infection-associated immunopathology. Primary objectives are identification of (i) innate sensing receptors for pathogens in different hosts (pigs, chicken, bovine, human, mouse ...
The Impact of Stress
... necessary amount of cortisol production. When the body experiences stress, increased cortisol production occurs. This in turn initiates the necessary glucose production, a major fuel for energy, via the liver. If the accumulation of stressors reaches high enough levels in both intensity and duration ...
... necessary amount of cortisol production. When the body experiences stress, increased cortisol production occurs. This in turn initiates the necessary glucose production, a major fuel for energy, via the liver. If the accumulation of stressors reaches high enough levels in both intensity and duration ...
Prognostic Significance of Absolute Lymphocyte Count and
... Broader understanding of lymphoma biology and host immune system led the investigators to look for new prognostic markers that could better predict disease outcome in the era of immuno-chemotherapy. Novel molecular markers have been introduced as independent predictors of outcome in lymphomas, but t ...
... Broader understanding of lymphoma biology and host immune system led the investigators to look for new prognostic markers that could better predict disease outcome in the era of immuno-chemotherapy. Novel molecular markers have been introduced as independent predictors of outcome in lymphomas, but t ...
Gene Section FCER2 (Fc fragment of IgE, low affinity II, receptor
... FCER2 is the low-affinity immunoglobin E receptor. It mediates various biological functions. Mainly, it is involved in the down regulation of IgE production by B cells. However, because of its ability to associate with various ligands, its effects on IgE regulation might be stimulatory as well. In f ...
... FCER2 is the low-affinity immunoglobin E receptor. It mediates various biological functions. Mainly, it is involved in the down regulation of IgE production by B cells. However, because of its ability to associate with various ligands, its effects on IgE regulation might be stimulatory as well. In f ...
Viral immune evasion: a masterpiece of evolution
... et al. 1996a). This route of degradation is normally used in cells to degrade class I heavy chains that fail to assemble into multimeric complexes, either due to misfolding or to incapability to bind peptides (Wiertz et al. 1996a; Hughes et al. 1997). A distinction between US2/US11mediated degradati ...
... et al. 1996a). This route of degradation is normally used in cells to degrade class I heavy chains that fail to assemble into multimeric complexes, either due to misfolding or to incapability to bind peptides (Wiertz et al. 1996a; Hughes et al. 1997). A distinction between US2/US11mediated degradati ...
The INFLAMMASOMES Guardians of the Body
... Danger signal binds to purinoreceptor P2X7 thereby activating NALP3 and caspase-1 Extracellular ATP in vivo my be rapidly hydrolyzed. Other ATP sourses - insulin containing granules from pancreatic cells - microbial flora and pathogenes ASC deficient mice demonstrated that ATP mediated caspase-1 a ...
... Danger signal binds to purinoreceptor P2X7 thereby activating NALP3 and caspase-1 Extracellular ATP in vivo my be rapidly hydrolyzed. Other ATP sourses - insulin containing granules from pancreatic cells - microbial flora and pathogenes ASC deficient mice demonstrated that ATP mediated caspase-1 a ...
Untitled - Moffitt Cancer Center
... overcome the predator-like effects of the immune system during the course of their development and that harnessing the immune response to tumors could be an effective therapy. However, only in the last few years has immunotherapy begun to fulfill its promise as new agents and strategies are beginnin ...
... overcome the predator-like effects of the immune system during the course of their development and that harnessing the immune response to tumors could be an effective therapy. However, only in the last few years has immunotherapy begun to fulfill its promise as new agents and strategies are beginnin ...
research design and methods
... described (4). Chemotaxis activity was evaluated by flow cytometry on peritoneal macrophages incubated with fluoresceinlabeled casein (Invitrogen-Molecular Probes, Merelbeke, Belgium). Fluorescein-labeled zymosan particles (Saccharomyces cerevisiae; Invitrogen-Molecular Probes) were used to evaluate ...
... described (4). Chemotaxis activity was evaluated by flow cytometry on peritoneal macrophages incubated with fluoresceinlabeled casein (Invitrogen-Molecular Probes, Merelbeke, Belgium). Fluorescein-labeled zymosan particles (Saccharomyces cerevisiae; Invitrogen-Molecular Probes) were used to evaluate ...
DESIGN AND IMPLEMENTATION
... • Blocking of activated T and B cell proliferation and antibody formation ...
... • Blocking of activated T and B cell proliferation and antibody formation ...
Evaluation of Large Panels of Bispecific Antibodies
... visualizations to remove quality artifacts and select the best hits. Data from multiple instrument runs can be analyzed jointly, even if acquired on different instruments or by different groups. The screenshot illustrates a side-by-side comparison of BsAbs from a primary high-throughput off-rate ran ...
... visualizations to remove quality artifacts and select the best hits. Data from multiple instrument runs can be analyzed jointly, even if acquired on different instruments or by different groups. The screenshot illustrates a side-by-side comparison of BsAbs from a primary high-throughput off-rate ran ...
Gene Section GPA33 (glycoprotein A33 (transmembrane)) Atlas of Genetics and Cytogenetics
... complex is internalized and sequestered in vesicles (Daghighian et al., 1996). Selective immunological targeting of tumors with monoclonal antibodies (mAb) is an important therapeutic approach in cancer therapy. Clinical imaging and biopsy-based biodistribution studies using radiolabeled murine mAb ...
... complex is internalized and sequestered in vesicles (Daghighian et al., 1996). Selective immunological targeting of tumors with monoclonal antibodies (mAb) is an important therapeutic approach in cancer therapy. Clinical imaging and biopsy-based biodistribution studies using radiolabeled murine mAb ...
Curriculum Vitae
... 45. Wang P, Sidney J, Dow C, Mothé B, Sette A, Peters B. A systematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approach. PLoS Comput Biol. 2008 Apr 4;4(4):e1000048. PMCID: PMC2267221 46. Assarsson E, Greenbaum JA, Sundström M, Schaffer L, Hammond JA, Pasqu ...
... 45. Wang P, Sidney J, Dow C, Mothé B, Sette A, Peters B. A systematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approach. PLoS Comput Biol. 2008 Apr 4;4(4):e1000048. PMCID: PMC2267221 46. Assarsson E, Greenbaum JA, Sundström M, Schaffer L, Hammond JA, Pasqu ...
game changer for cancer
... inflammation) is being combined with cancer vaccines. Other trials are combining Keytruda and Yervoy, or adding in vaccines or battalions of T-cells. Tailoring the treatment to each patient is crucial, because each cancer, in effect, requires a different type of battle plan. “We are just scratching ...
... inflammation) is being combined with cancer vaccines. Other trials are combining Keytruda and Yervoy, or adding in vaccines or battalions of T-cells. Tailoring the treatment to each patient is crucial, because each cancer, in effect, requires a different type of battle plan. “We are just scratching ...
Major Histocompatibility Complex (MHC)
... • Crossing over frequency (0.5%) between MHC genes is very less. • Thus, MHC alleles present on one chromosome tends to remain as such and inherited as set. • This set of MHC alleles is generally termed as “Haplotype”. • Thus, a person have two haplotypes transferred from mother and father. • MHC Al ...
... • Crossing over frequency (0.5%) between MHC genes is very less. • Thus, MHC alleles present on one chromosome tends to remain as such and inherited as set. • This set of MHC alleles is generally termed as “Haplotype”. • Thus, a person have two haplotypes transferred from mother and father. • MHC Al ...
Cell proliferation in human epiretinal membranes:
... Purpose: To quantify the extent of cellular proliferation and immunohistochemically characterize the proliferating cell types in epiretinal membranes (ERMs) from four different conditions: proliferative vitreoretinopathy (PVR), proliferative diabetic retinopathy, post–retinal detachment, and idiopat ...
... Purpose: To quantify the extent of cellular proliferation and immunohistochemically characterize the proliferating cell types in epiretinal membranes (ERMs) from four different conditions: proliferative vitreoretinopathy (PVR), proliferative diabetic retinopathy, post–retinal detachment, and idiopat ...
Polyclonal B cell response
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.