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The Immune System
The Immune System

...  The WBC’s are called phagocytes- they engulf and destroy the pathogens.  Inflammatory responses include a red, swollen, warm area and sometimes fever. 3. Immune Response- these cells can distinguish between different kinds of pathogens and react to each kind with a specific defense. ...
File
File

...  The WBC’s are called phagocytes- they engulf and destroy the pathogens.  Inflammatory responses include a red, swollen, warm area and sometimes fever. 3. Immune Response- these cells can distinguish between different kinds of pathogens and react to each kind with a specific defense. ...
The Specific/Adaptive Immune Response
The Specific/Adaptive Immune Response

... –Also called immunoglobulins (Ig) –Soluble, proteinaceous molecules that bind antigen –Secreted by plasma cells, which are B cells actively fighting exogenous antigen –Considered part of the humoral immune response since bodily fluids such as lymph and blood were once called humors Antibody Function ...
Specific resistance to infection
Specific resistance to infection

Chapter 40 Notes
Chapter 40 Notes

... B cells grow and divide rapidly, produce large numbers of plasma cells and memory B cells. Plasma cell release antibodies, proteins that recognize and bind to antigens. The antibodies are carried in the bloodstream to attack the pathogen that is causing the infection. As the antibodies overcome the ...
basicprinciplesofimmunesystem
basicprinciplesofimmunesystem

... kalor  heat dolor  painful  functio laesa (loss of function) of infected tissue ...
The Lymphatic System and Body Defenses
The Lymphatic System and Body Defenses

...  Human cells have many surface proteins  Our immune cells do not attack our own proteins  Our cells in another person’s body can trigger an immune response because they are foreign  Restricts donors for transplants Allergies  Many small molecules (called haptens or incomplete antigens) are not ...
Exam Key 2 2008
Exam Key 2 2008

Packet - Humble ISD
Packet - Humble ISD

... Page 30 (“Specific Defenses Notes”): To be filled out in class Specific Defenses- Attacks the particular disease causing agents 1. Antibody - Antigens stimulate production of_______________. Antibody has two binding sites. An antibody matches an antigen much as a key matches a lock. Whenever they in ...
CL8
CL8

... 1. 1st line of defense – skin and mucous membranes in nose and throat – act as a filter/barrier to pathogens. 2. Macrophages (a type of white blood cell) will recognize foreign bacteria and kill it. 3. After the extended presence of pathogens in the body, the immune system will make other types of w ...
Week 11 - Immune Responses - NSW and VIC Biology for Year
Week 11 - Immune Responses - NSW and VIC Biology for Year

... blood cells formed in the bone marrow and spleen.) Immune responses include both humoral (‘blood-borne’) and cellmediated mechanisms. In humoral immunity antibodies are released by B cells; in cell-mediated immunity, active destruction is carried out by T cells. Antigens are molecules able to bind t ...
Sistem Keta - IGP355 – PATOFISIOLOGI PENYAKIT II
Sistem Keta - IGP355 – PATOFISIOLOGI PENYAKIT II

...  Also plays a role in protection against parasitic worm infections. ...
Chapter 9 Immunity and the Lymphatic System Our body`s innate
Chapter 9 Immunity and the Lymphatic System Our body`s innate

... o Can be brought about naturally through an infection or artificially through medical intervention There are two types of immunity - active and passive Active immunity o The individual’s body makes antibodies against a particular antigen o This can happen through natural infection or through immuniz ...
Immune System A
Immune System A

... encounter antigens they may later attack Are exported to secondary lymphoid tissue where encounters with antigens occur Mature into fully functional antigen-activated cells upon binding with their recognized antigen It is genes, not antigens, that determine which foreign substances our immune system ...
Any antibody binds to only a portion of the
Any antibody binds to only a portion of the

... antibody molecule (BCR) or T cell receptor (TCR) ...
NOTES: Specific Defenses / Immunity (Ch 14, part 3)
NOTES: Specific Defenses / Immunity (Ch 14, part 3)

... *(antibodies react against the antigen that stimulated their production!)…more on this later AND 4) activated B cells also differentiate into MEMORY B CELLS (respond to subsequent exposures of the same antigen) ...
autumn 11 newsletter
autumn 11 newsletter

... defense. Now, other types of white blood cells called B and T lymphocytes are mobilized to identify, tag, and kill invaders more efficiently. They also develop a memory for the invader so the immune system can recognize it quickly, should there be a reinfection. ...
Topic 6.3 Defence against infectious disease
Topic 6.3 Defence against infectious disease

... Plasma ɞ cells have a different shape receptor on its membrane. There are about 10 million kinds in your body at any one time! Each can detect any antigen of a pathogen. Once activated they divide very fast (clone) and start to secrete specific antibodies. Antibodies slowly removed from blood and ly ...
13 The Lymphatic System and Immunity
13 The Lymphatic System and Immunity

... provide antibody-mediated immunity by producing antibodies against foreign antigens and T lymphocytes provide cell-mediated immunity by directly attacking cells which bear antigens recognized as foreign to the body. Antibodies produced by B cells bind to specific antigens on the surfaces of microbes ...
B. Are the main cells involved in acute inflammation
B. Are the main cells involved in acute inflammation

... D all above 3 Haptens are the molecules that A possess antigenicity C possess immunogenicity B are large protein D can induce the production of antibody 4 The first immunoglobulin class produced in a primary response to an antigen is A IgA B IgG C IgM D IgE 5 The most abundant immunoglobulin class i ...
Mammalian Differentiated Cell Types, Part 2
Mammalian Differentiated Cell Types, Part 2

... Leucocytes (white blood cells) protect against infections. Blood contains about one leucocyte for every 100 red blood cells. Although leucocytes travel in the circulation, they can pass through the walls of blood vessels to do their work in the surrounding tissues. There are several different kinds, ...
Lymphatic System
Lymphatic System

...  Attack cells infected ...
國立嘉義大學九十七學年度
國立嘉義大學九十七學年度

... immune cells attack their targets, various cytotoxic proteins such as lymphotoxin, tumor necrosis factor α (TNF-α), NK cytotoxic factor, perforin, and toxic molecules such as NO and reactive oxygen species (ROS) are typically involved. Most notably, TNF-α was originally characterized as a tumor-necr ...
35-3 and 35-4 PowerPoint Notes
35-3 and 35-4 PowerPoint Notes

... Active immunity may develop as a result of natural exposure to an __________ (fighting an infection) or from deliberate exposure to the antigen (through a vaccine). The immune system produces memory B cells and memory T cells that quicken and __________ the body’s response to repeated infection. Pas ...
Holly Gets Sick
Holly Gets Sick

... 5. What type of defense cell kills both infected and non-infected cells in Holly’s body? ____________________________ 6. What type of defense cell moves through tissues “cleaning up” cellular debris from Holly’s infection? ____________________________ How do they do this? ...
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Adaptive immune system



The adaptive immune system, also known as the acquired immune or, more rarely, as the specific immune system, is a subsystem of the overall immune system that is composed of highly specialized, systemic cells and processes that eliminate or prevent pathogen growth. The adaptive immune system is one of the two main immunity strategies found in vertebrates (the other being the innate immune system). Adaptive immunity creates immunological memory after an initial response to a specific pathogen, leads to an enhanced response to subsequent encounters with that pathogen. This process of acquired immunity is the basis of vaccination. Like the innate system, the adaptive system includes both humoral immunity components and cell-mediated immunity components.Unlike the innate immune system, the adaptive immune system is highly specific to a specific pathogen. Adaptive immunity can also provide long-lasting protection: for example; someone who recovers from measles is now protected against measles for their lifetime but in other cases it does not provide lifetime protection: for example; chickenpox. The adaptive system response destroys invading pathogens and any toxic molecules they produce. Sometimes the adaptive system is unable to distinguish foreign molecules, the effects of this may be hayfever, asthma or any other allergies. Antigens are any substances that elicit the adaptive immune response. The cells that carry out the adaptive immune response are white blood cells known as lymphocytes. Two main broad classes—antibody responses and cell mediated immune response—are also carried by two different lymphocytes (B cells and T cells). In antibody responses, B cells are activated to secrete antibodies, which are proteins also known as immunoglobulins. Antibodies travel through the bloodstream and bind to the foreign antigen causing it to inactivate, which does not allow the antigen to bind to the host.In acquired immunity, pathogen-specific receptors are ""acquired"" during the lifetime of the organism (whereas in innate immunity pathogen-specific receptors are already encoded in the germline). The acquired response is called ""adaptive"" because it prepares the body's immune system for future challenges (though it can actually also be maladaptive when it results in autoimmunity).The system is highly adaptable because of somatic hypermutation (a process of accelerated somatic mutations), and V(D)J recombination (an irreversible genetic recombination of antigen receptor gene segments). This mechanism allows a small number of genes to generate a vast number of different antigen receptors, which are then uniquely expressed on each individual lymphocyte. Because the gene rearrangement leads to an irreversible change in the DNA of each cell, all progeny (offspring) of that cell inherit genes that encode the same receptor specificity, including the memory B cells and memory T cells that are the keys to long-lived specific immunity.A theoretical framework explaining the workings of the acquired immune system is provided by immune network theory. This theory, which builds on established concepts of clonal selection, is being applied in the search for an HIV vaccine.
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