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lac-1
lac-1

... called a T suppressor (TS) cell, has been postulated, recent evidence suggests that it may not be distinct from TH and TC subpopulations. T helper and T cytotoxic cells can be distinguished from one another by the presence of either CD4 or CD8 membrane glycoproteins on their surfaces ). T cells disp ...
Stages of lymphocyte maturation (Abbas Chapter 8)
Stages of lymphocyte maturation (Abbas Chapter 8)

LOYOLA COLLEGE (AUTONOMOUS), CHENNAI
LOYOLA COLLEGE (AUTONOMOUS), CHENNAI

... (4) Which one of the following provides active immunity? (a) antitoxins (b) breast milk (c) vaccines (d) maternal antibody (5) Which one of the following technique is used for counting different types of cells? (a) Flow cytometry (b) Immunochromatography (c) Western blotting (d) Agglutination II. St ...
Natural
Natural

... any priming or prior activation (remember that e.g. cytotoxic T cells need priming by antigen presenting cells) and their name is ultimately connected to this ‘natural’ ability to kill. Additionally, NK cells secrete cytokines, as for example INFg and TNFa, which constitute a second important defenc ...
03-Chapter
03-Chapter

... Organs and tissues involved in recognizing foreign substances Phagocytic cells are strategically located in these organs, adjacent to blood and lymphatic vessels Cells ...
chapter15
chapter15

... Becomes apparent within a few days after infection Principally mediated by two types of cells T cells that secrete cytokines (which are proteins) that mediate local immune responses B cells that secrete high affinity antibodies that noncovalently bind to microbes and their products ...
The bright light produced at the CLS allows researchers to see the
The bright light produced at the CLS allows researchers to see the

... down to a 2.3 angstrom resolution. Understanding the three-dimensional structural details of a therapeutic antibody can help in understanding its physical properties and how it interacts with receptors in the body. Certain cancer cells are able to express PD-L1 molecules which interact with PD-1 mol ...
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... critical for IFN and inflammatory gene expression during innate immune responses. However, the role of STING in adaptive immunity is still unknown. In this study, we show that STING activation reduces the proliferation of T lymphocytes. This activity was independent of TBK1 and IRF3 recruitment and o ...
Blood Groups and Immunogenetics
Blood Groups and Immunogenetics

... "Acquired immunity" refers to the fact that we can respond to invasion by a "foreign" organism only after exposure; our system is able to recognize "antigens" as foreign. Antigens are molecules (usually proteins) that differ in some way from our own natural proteins. The proteins on one persons' cel ...
At its Heart, Homeostasis Is About T Cells
At its Heart, Homeostasis Is About T Cells

... reactivity to antigens is tonically controlled by ...
Human Blood Groups
Human Blood Groups

... – One inherited from each parent – AA and A_ type A – BB and B_ type B – AB type AB – Neither type O ...
Dissertation title: Bordetella Adenylate Cyclase: Molecular
Dissertation title: Bordetella Adenylate Cyclase: Molecular

... by Gram-negative bacteria and primarily targets myeloid phagocytes, expressing the CD11b/CD18 integrin receptor (also known as αMβ2, CR3 or Mac-1). Upon binding, CyaA permeabilizes cell membranes by forming small cation-selective pores, and subverts cellular signaling by delivering into host cells a ...
GROWTH MEDIA OCULAR INFECTION
GROWTH MEDIA OCULAR INFECTION

... mediated • Th1 primarily cellular with a great deal of adjacent tissue damage • Th2 primarily humoral less collateral tissue damage ...
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tib3handout_me

... Effects on tissues on the implant and implant on the tissues are both important factors. Most result from alterations of normal physiological processes for example immunity, inflammation and blood coagulation. These are host defence mechanisms which protect us from dangerous external threats such as ...
organization of the immune system
organization of the immune system

... •Up to puberty/adolescence the size of the thymus is increasing and naive T lymphocytes are produced in waves to ensure protective immune responses •A sustained loss of tissue mass, cellularity and functionality of the thymus starts after puberty and lasts to middle age followed by a slower rate of ...
Immunity
Immunity

... Immunoglobulin A (IgA) Immunoglobulin G (IgG) Immunoglobulin M (IgM) Immunoglobulin D (IgD) Immunoglobulin E (IgE) ...
HIV and immunity
HIV and immunity

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Blood System
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... leukocytes (polys) or segmented neutrophils (segs) • Increase in %  bacterial or some fungal infections • Destroy bacteria by phagocytosis • Life span: 0.5 – 9 days ...
Immune System Lecture_Spring 2002
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... d. Memory: quicker and stronger response to previously encountered pathogens ...
Nonspecific vs. Specific Defense Mechanisms
Nonspecific vs. Specific Defense Mechanisms

... d. Memory: quicker and stronger response to previously encountered pathogens ...
Defense against disease, immune response
Defense against disease, immune response

... Vector - insect or other animal transmitting pathogenic organism from host to host Virulence - degree to which an organism can cause disease Pathogen - organism able to cause disease in host ...
Immune responses in viral infections
Immune responses in viral infections

... eliminating the bacteria and at neutralizing the effects of their toxins. Innate immunity: 1. Phagocytosis by macrophages and neutrophils. 2. Complement activation and inflammation. Complement activation leads to phagocytosis and lysis. Gram positive bacteria contain peptidoglycan that activate alte ...
bahan kuliah eksperimentasi immunofarmakologi
bahan kuliah eksperimentasi immunofarmakologi

... Growth and differentiation factors (cytokines) produced by and present on bone marrow stromal cells determine the type of white blood cell that will emerge, as well as their relative numbers. ...
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Adaptive immune system



The adaptive immune system, also known as the acquired immune or, more rarely, as the specific immune system, is a subsystem of the overall immune system that is composed of highly specialized, systemic cells and processes that eliminate or prevent pathogen growth. The adaptive immune system is one of the two main immunity strategies found in vertebrates (the other being the innate immune system). Adaptive immunity creates immunological memory after an initial response to a specific pathogen, leads to an enhanced response to subsequent encounters with that pathogen. This process of acquired immunity is the basis of vaccination. Like the innate system, the adaptive system includes both humoral immunity components and cell-mediated immunity components.Unlike the innate immune system, the adaptive immune system is highly specific to a specific pathogen. Adaptive immunity can also provide long-lasting protection: for example; someone who recovers from measles is now protected against measles for their lifetime but in other cases it does not provide lifetime protection: for example; chickenpox. The adaptive system response destroys invading pathogens and any toxic molecules they produce. Sometimes the adaptive system is unable to distinguish foreign molecules, the effects of this may be hayfever, asthma or any other allergies. Antigens are any substances that elicit the adaptive immune response. The cells that carry out the adaptive immune response are white blood cells known as lymphocytes. Two main broad classes—antibody responses and cell mediated immune response—are also carried by two different lymphocytes (B cells and T cells). In antibody responses, B cells are activated to secrete antibodies, which are proteins also known as immunoglobulins. Antibodies travel through the bloodstream and bind to the foreign antigen causing it to inactivate, which does not allow the antigen to bind to the host.In acquired immunity, pathogen-specific receptors are ""acquired"" during the lifetime of the organism (whereas in innate immunity pathogen-specific receptors are already encoded in the germline). The acquired response is called ""adaptive"" because it prepares the body's immune system for future challenges (though it can actually also be maladaptive when it results in autoimmunity).The system is highly adaptable because of somatic hypermutation (a process of accelerated somatic mutations), and V(D)J recombination (an irreversible genetic recombination of antigen receptor gene segments). This mechanism allows a small number of genes to generate a vast number of different antigen receptors, which are then uniquely expressed on each individual lymphocyte. Because the gene rearrangement leads to an irreversible change in the DNA of each cell, all progeny (offspring) of that cell inherit genes that encode the same receptor specificity, including the memory B cells and memory T cells that are the keys to long-lived specific immunity.A theoretical framework explaining the workings of the acquired immune system is provided by immune network theory. This theory, which builds on established concepts of clonal selection, is being applied in the search for an HIV vaccine.
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