Psychostimulants and Cognition: A Continuum of Behavioral and
... This continuum complements earlier work by Lyon and Robbins (1975), in which an inverted U–shaped function of amphetamine effects on specific rodent behaviors is described. They theorized that a “single increasing stimulatory effect” can account for both sides of the curve, with amphetamine resultin ...
... This continuum complements earlier work by Lyon and Robbins (1975), in which an inverted U–shaped function of amphetamine effects on specific rodent behaviors is described. They theorized that a “single increasing stimulatory effect” can account for both sides of the curve, with amphetamine resultin ...
Fenylefrin Abcur solution for injection ENG SmPC
... neurological effects. Phenylephrine Abcur should not be used during lactation unless the potential benefit outweighs the potential risk. ...
... neurological effects. Phenylephrine Abcur should not be used during lactation unless the potential benefit outweighs the potential risk. ...
Chapter 9: Empirical Evidence of the Effects of Amphetamine on
... because the compound causes brain damage, ethical concerns have prevented experimental research on the behavioral effects of amphetamine. Thus, the available literature on the effects of amphetamine in human participants is all correlational. Although there have been reports of high correlations bet ...
... because the compound causes brain damage, ethical concerns have prevented experimental research on the behavioral effects of amphetamine. Thus, the available literature on the effects of amphetamine in human participants is all correlational. Although there have been reports of high correlations bet ...
Truflo pressurised inhalation, suspension ENG SmPC
... Prolonged treatment with high doses of inhaled corticosteroids may result in adrenal suppression and acute adrenal crisis. In very rare cases, adrenal suppression and acute adrenal crisis has occurred at doses of between 500 and 1000 micrograms of fluticasone propionate. Situations, which could pote ...
... Prolonged treatment with high doses of inhaled corticosteroids may result in adrenal suppression and acute adrenal crisis. In very rare cases, adrenal suppression and acute adrenal crisis has occurred at doses of between 500 and 1000 micrograms of fluticasone propionate. Situations, which could pote ...
Adult Diabetes
... Boxed Warning: Do not use Victoza/Bydureon if patient or family members have a history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2. – Risk of thyroid C-cell tumors with Victoza & Bydureon Associated with acute pancreatitis including fatal & non-fatal hemorrhagic o ...
... Boxed Warning: Do not use Victoza/Bydureon if patient or family members have a history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2. – Risk of thyroid C-cell tumors with Victoza & Bydureon Associated with acute pancreatitis including fatal & non-fatal hemorrhagic o ...
Anabolic steroid induced acute myocardial infarction ABSTRACT
... Androgenic anabolic steroids are commonly abused by athletes and body-builders to help develop lean body mass and muscular strength to enhance their performance. However, at doses which are much higher than recommended therapeutic dosage, abuse of these drugs is commonly associated with cardiovascul ...
... Androgenic anabolic steroids are commonly abused by athletes and body-builders to help develop lean body mass and muscular strength to enhance their performance. However, at doses which are much higher than recommended therapeutic dosage, abuse of these drugs is commonly associated with cardiovascul ...
Acute Effects of d-Amphetamine on the Differential Reinforcement of
... the perception of time are the two main effects which can be observed with the use of amphetamine or its derivatives by human subjects (8, 24). In laboratory animals, operant behavior maintained on the ...
... the perception of time are the two main effects which can be observed with the use of amphetamine or its derivatives by human subjects (8, 24). In laboratory animals, operant behavior maintained on the ...
Ef fects of bupropion and me ca mylamine on mo ti va tional ef fects
... Several laboratories have developed a reinstatement procedure based on the CPP, which is a simple non-invasive method, compatible with the classical Pavlovian conditioning [20]. In these studies, preference to one distinctive environment associated with a drug administration during conditioning can ...
... Several laboratories have developed a reinstatement procedure based on the CPP, which is a simple non-invasive method, compatible with the classical Pavlovian conditioning [20]. In these studies, preference to one distinctive environment associated with a drug administration during conditioning can ...
Effect of Caffeine on the Ventilatory Response to CO2 in
... Breathing is controlled by the respiratory center in the medulla oblongata. When an infant’s medulla is immature, it occasionally ceases breathing and does not respond to signals from chemoreceptors even when the carbon dioxide (CO2) concentration in the body increases. Apnea in neonates, which may ...
... Breathing is controlled by the respiratory center in the medulla oblongata. When an infant’s medulla is immature, it occasionally ceases breathing and does not respond to signals from chemoreceptors even when the carbon dioxide (CO2) concentration in the body increases. Apnea in neonates, which may ...
PEPZAN - Medsafe
... In patients treated for 6 months with famotidine 20 mg twice daily, relapse of oesophageal erosions or ulceration was significantly less than in patients treated with placebo. Famotidine was also shown to be superior to placebo in preventing symptomatic deterioration. Famotidine had little or no eff ...
... In patients treated for 6 months with famotidine 20 mg twice daily, relapse of oesophageal erosions or ulceration was significantly less than in patients treated with placebo. Famotidine was also shown to be superior to placebo in preventing symptomatic deterioration. Famotidine had little or no eff ...
Product Monograph Template - Standard
... lactating rats indicate that maraviroc is extensively excreted into rat milk. It is unknown whether maraviroc is excreted into human milk. Mothers should be instructed not to breast-feed if they are receiving CELSENTRI because of both the potential for HIV transmission and any possible undesirable e ...
... lactating rats indicate that maraviroc is extensively excreted into rat milk. It is unknown whether maraviroc is excreted into human milk. Mothers should be instructed not to breast-feed if they are receiving CELSENTRI because of both the potential for HIV transmission and any possible undesirable e ...
Caffeine: Hero or Zero Caffeine is the most widely used, legal drug
... dependent or addicted. Of course more and more will have to be consumed to produce the same effects within the body due to the increased tolerance of the substance. Moderate amounts of caffeine are ...
... dependent or addicted. Of course more and more will have to be consumed to produce the same effects within the body due to the increased tolerance of the substance. Moderate amounts of caffeine are ...
SAFE n Smart* Use of Sulfonylureas
... • Begin with low doses and up-titrate slowly, at weekly or fortnightly intervals • Avoid using more than half-maximal doses Prescription • SUs should ideally be used if one or two other drug classes fail to achieve glycaemic targets • Avoid using SUs in conjunction with another SU and/or premixed or ...
... • Begin with low doses and up-titrate slowly, at weekly or fortnightly intervals • Avoid using more than half-maximal doses Prescription • SUs should ideally be used if one or two other drug classes fail to achieve glycaemic targets • Avoid using SUs in conjunction with another SU and/or premixed or ...
ICH M3 (R2): Non-Clinical Safety Studies for the Conduct of Human
... studies to support the various stages of clinical development among the regions of Europe, USA, and Japan. The present guideline represents the consensus that exists regarding the scope and duration of nonclinical safety studies to support the conduct of human clinical trials and marketing authoriza ...
... studies to support the various stages of clinical development among the regions of Europe, USA, and Japan. The present guideline represents the consensus that exists regarding the scope and duration of nonclinical safety studies to support the conduct of human clinical trials and marketing authoriza ...
ASCO 2011 NKTR-102 PopPK Poster
... were not considered clinically important. Patient age, hepatic or renal functions were not correlated with SN38 CL. Coadministration of cetuximab had no effects on NKTR-102 PK and vice versa. PK in pts with ovarian and breast cancer were similar to those with non-ovarian or -breast tumors. The RP2D ...
... were not considered clinically important. Patient age, hepatic or renal functions were not correlated with SN38 CL. Coadministration of cetuximab had no effects on NKTR-102 PK and vice versa. PK in pts with ovarian and breast cancer were similar to those with non-ovarian or -breast tumors. The RP2D ...
Drugs Acting on the Respiratory System
... airways in which many cells and cellular elements play a role, in particular, mast cells, eosinophils, T lymphocytes, macrophages, neutrophils, and epithelial cells. In susceptible individuals, this inflammation causes recurrent episodes of wheezing, breathlessness, chest tightness, and coughing, pa ...
... airways in which many cells and cellular elements play a role, in particular, mast cells, eosinophils, T lymphocytes, macrophages, neutrophils, and epithelial cells. In susceptible individuals, this inflammation causes recurrent episodes of wheezing, breathlessness, chest tightness, and coughing, pa ...
MS_Word ~ 89 KB
... norpethidine.6 Several cases of seizures have been reported, including when pethidine was used for patient controlled analgesia (PCA) 6. In Australia alone, between 1975 and 1997, ADRAC (Adverse Drug Reactions Advisory Committee) received 35 reports describing convulsions in association with pethidi ...
... norpethidine.6 Several cases of seizures have been reported, including when pethidine was used for patient controlled analgesia (PCA) 6. In Australia alone, between 1975 and 1997, ADRAC (Adverse Drug Reactions Advisory Committee) received 35 reports describing convulsions in association with pethidi ...
Facts about Buprenorphine (Suboxone ) ®
... severe headaches are occasionally reported and moderate headaches are common during the first few days of induction. • Taking large doses of methadone can cause and has caused deaths; taking large doses of buprenorphine is much less likely to cause overdose and possible death if it’s the only ...
... severe headaches are occasionally reported and moderate headaches are common during the first few days of induction. • Taking large doses of methadone can cause and has caused deaths; taking large doses of buprenorphine is much less likely to cause overdose and possible death if it’s the only ...
SUBLIMAZE Injection
... from 100-400 micrograms/kg, produce an immediate fall in blood pressure, followed by partial recovery, and a sustained hypotensive effect lasting up to 30 minutes. Fentanyl produces a minimum of cortical depression, and it is suggested that it exerts its action by filling receptor sites located in t ...
... from 100-400 micrograms/kg, produce an immediate fall in blood pressure, followed by partial recovery, and a sustained hypotensive effect lasting up to 30 minutes. Fentanyl produces a minimum of cortical depression, and it is suggested that it exerts its action by filling receptor sites located in t ...
Neuroleptics (Anti-psychotic Drugs)
... By the end of the course the students will be able to ☛ Outline the dopamine hypothesis of schizophrenia. ☛ Explain the mechanism of action of each drug in each class. ☛ Describe the antipsychotic action of neuroleptics. ☛ List the main pharmacokinetic features of neuroleptics ☛ Outline the use of d ...
... By the end of the course the students will be able to ☛ Outline the dopamine hypothesis of schizophrenia. ☛ Explain the mechanism of action of each drug in each class. ☛ Describe the antipsychotic action of neuroleptics. ☛ List the main pharmacokinetic features of neuroleptics ☛ Outline the use of d ...
Presented at ICAAC 2015, San Diego, CA, USA
... levels were below the limit of quantification (5 ng/mL) in the majority of samples, indicating pre-systemic conversion of the prodrug into the active moiety Debio 1452, which showed median tmax at 2.75–4 h post-dose. Debio 1452 then declined mono-exponentially with mean terminal half-lives of 9–12 h. ...
... levels were below the limit of quantification (5 ng/mL) in the majority of samples, indicating pre-systemic conversion of the prodrug into the active moiety Debio 1452, which showed median tmax at 2.75–4 h post-dose. Debio 1452 then declined mono-exponentially with mean terminal half-lives of 9–12 h. ...
Report on the Investigation Results
... Japanese Journal of Psychiatric Treatment 2013; 28: 232-236 7 Therapeutic dose dependence with the use of BZ receptor agonists is described as “a clinical condition where the primary disease has improved but the patient has difficulty in stopping the drug as rebound phenomena or withdrawal symptoms ...
... Japanese Journal of Psychiatric Treatment 2013; 28: 232-236 7 Therapeutic dose dependence with the use of BZ receptor agonists is described as “a clinical condition where the primary disease has improved but the patient has difficulty in stopping the drug as rebound phenomena or withdrawal symptoms ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... process of the rats remain conserved without any catabolism 12. There was also no significant changes in hematological parameters (WBC, RBC, Hb, HCT,MCV, MCHC, PLT,MPV, DC, PLT CRIT, PDW%) in the test groups (Table 2&3). Analysis of haematological parameters can be associated with the safety in huma ...
... process of the rats remain conserved without any catabolism 12. There was also no significant changes in hematological parameters (WBC, RBC, Hb, HCT,MCV, MCHC, PLT,MPV, DC, PLT CRIT, PDW%) in the test groups (Table 2&3). Analysis of haematological parameters can be associated with the safety in huma ...
Hormesis
Hormesis (from Greek hórmēsis ""rapid motion, eagerness,"" from ancient Greek hormáein ""to set in motion, impel, urge on"") is the term for generally favorable biological responses to low exposures to toxins and other stressors. A pollutant or toxin showing hormesis thus has the opposite effect in small doses as in large doses. A related concept is Mithridatism, which refers to the willful exposure to toxins in an attempt to develop immunity against them. Hormetics is the term proposed for the study and science of hormesis.In toxicology, hormesis is a dose response phenomenon characterized by a low dose stimulation, high dose inhibition, resulting in either a J-shaped or an inverted U-shaped dose response. Such environmental factors that would seem to produce positive responses have also been termed ""eustress.""The hormesis model of dose response is vigorously debated. The notion that hormesis is important for chemical risks regulations is not widely accepted.The biochemical mechanisms by which hormesis works are not well understood. It is conjectured that low doses of toxins or other stressors might activate the repair mechanisms of the body. The repair process fixes not only the damage caused by the toxin, but also other low-level damage that might have accumulated before without triggering the repair mechanism.