Anticoagulant resistance in the Norway rat and Guidelines for the
... south Berkshire also having this resistance. It was known in early research papers as “difenacoumresistance” but the strain shows resistance to other compounds as well. Resistant rats from this focus carry the mutation Leu120Gln. The term “Hampshire resistance” is now used when referring to this str ...
... south Berkshire also having this resistance. It was known in early research papers as “difenacoumresistance” but the strain shows resistance to other compounds as well. Resistant rats from this focus carry the mutation Leu120Gln. The term “Hampshire resistance” is now used when referring to this str ...
The Coat of Many Colors
... Again, keep in mind as you continue to read that the merle allele is NOT a color allele. I know we’ve said this before, but it’s worth repeating! We’ll need a few definitions to understand how merle works. For example, we briefly mentioned the meaning of allele earlier. Here’s an expanded definition ...
... Again, keep in mind as you continue to read that the merle allele is NOT a color allele. I know we’ve said this before, but it’s worth repeating! We’ll need a few definitions to understand how merle works. For example, we briefly mentioned the meaning of allele earlier. Here’s an expanded definition ...
Accepted Version - CSIRO Research Publications Repository
... Variation in DNA sequence can cause variation in gene expression, which influences quantitative phenotypic variation in organisms and is an important factor in natural variation. Gene expression regulatory networks are comprised of cis- and trans-acting factors, and differences in gene expression ar ...
... Variation in DNA sequence can cause variation in gene expression, which influences quantitative phenotypic variation in organisms and is an important factor in natural variation. Gene expression regulatory networks are comprised of cis- and trans-acting factors, and differences in gene expression ar ...
Repair of Site-Specific DNA Double-Strand Breaks in
... DSB repair by NHEJ is usually accompanied by loss or gain (or loss and gain) of nucleotides. Therefore, we evaluated the efficiency of DSB repair via NHEJ by testing for short deletions (<30 bp; often linked with classical NHEJ) and longer deletions (indicating alternative end joining; Deriano and Ro ...
... DSB repair by NHEJ is usually accompanied by loss or gain (or loss and gain) of nucleotides. Therefore, we evaluated the efficiency of DSB repair via NHEJ by testing for short deletions (<30 bp; often linked with classical NHEJ) and longer deletions (indicating alternative end joining; Deriano and Ro ...
Available as a free here - European Cystic Fibrosis Society
... in otherwise healthy males (also named “isolated CBAVD”) accounts for approximately 3% of cases of infertility. The incidence of CBAVD, based on estimations, is approximately 1 :1000 males [19–21]. While the prevalence of CF is very low in non-Caucasian countries, the prevalence of CBAVD does not se ...
... in otherwise healthy males (also named “isolated CBAVD”) accounts for approximately 3% of cases of infertility. The incidence of CBAVD, based on estimations, is approximately 1 :1000 males [19–21]. While the prevalence of CF is very low in non-Caucasian countries, the prevalence of CBAVD does not se ...
Participation of the proteasomal lid subunit Rpn11 in mitochondrial
... motif is highly conserved within some MPN domain proteins such as Rpn11 and Csn5, but is not present in others, such as the proteasomal subunit Rpn8, suggesting that the latter are not catalytically active but may play a structural role in their respective complexes. Although the above results clear ...
... motif is highly conserved within some MPN domain proteins such as Rpn11 and Csn5, but is not present in others, such as the proteasomal subunit Rpn8, suggesting that the latter are not catalytically active but may play a structural role in their respective complexes. Although the above results clear ...
Polymerase chain reaction (PCR) The polymerase chain reaction
... amplify a single or a few copies of a piece of DNA across several orders of magnitude, generating thousands to millions of copies of a particular DNA sequence. Developed in 1983 by Kary Mullis, PCR is now a common and often indispensable technique used in medical and biological research labs for a v ...
... amplify a single or a few copies of a piece of DNA across several orders of magnitude, generating thousands to millions of copies of a particular DNA sequence. Developed in 1983 by Kary Mullis, PCR is now a common and often indispensable technique used in medical and biological research labs for a v ...
Sleeping Beauty - Weber State University
... The natural process of horizontal gene transfer can be mimicked under laboratory conditions. In plants, transposable elements of the Ac/Ds and Spm families have been routinely introduced into heterologous species (Osborne and Baker, 1995). In animals, however, a major obstacle to the transfer of an ...
... The natural process of horizontal gene transfer can be mimicked under laboratory conditions. In plants, transposable elements of the Ac/Ds and Spm families have been routinely introduced into heterologous species (Osborne and Baker, 1995). In animals, however, a major obstacle to the transfer of an ...
Genome Rearrangements Caused by Depletion of Essential DNA
... cycle following gene-product depletion by promoter shut off (Yu et al. 2006). Spontaneous DNA damage was measured by the relocalization of the DNA damage checkpoint protein Ddc2 from a diffuse nuclear pattern to discrete subnuclear foci (Figure 1A) (Melo et al. 2001; Lisby et al. 2004). Following gr ...
... cycle following gene-product depletion by promoter shut off (Yu et al. 2006). Spontaneous DNA damage was measured by the relocalization of the DNA damage checkpoint protein Ddc2 from a diffuse nuclear pattern to discrete subnuclear foci (Figure 1A) (Melo et al. 2001; Lisby et al. 2004). Following gr ...
Clinical Implications of
... MTHFR coding sequence to T, which results in a change in the aminoacid sequence from alanine to valine, leading to a decrease in enzymatic activity [19,20]. While this gene mutation was found in 5%-15% of the cases abroad [21], there have been no large-scale studies on the MTHFR gene mutation freque ...
... MTHFR coding sequence to T, which results in a change in the aminoacid sequence from alanine to valine, leading to a decrease in enzymatic activity [19,20]. While this gene mutation was found in 5%-15% of the cases abroad [21], there have been no large-scale studies on the MTHFR gene mutation freque ...
How dormant origins promote complete genome replication
... is required for cells to deal properly with spontaneous errors that occur during DNA replication, even when no exogenous replicative stress is applied. Most significantly, both MCM2IRES-CreERT2 and MCM4Chaos3 mutant mice showed a dramatic increase in cancer (see below). Regulation of dormant origins ...
... is required for cells to deal properly with spontaneous errors that occur during DNA replication, even when no exogenous replicative stress is applied. Most significantly, both MCM2IRES-CreERT2 and MCM4Chaos3 mutant mice showed a dramatic increase in cancer (see below). Regulation of dormant origins ...
A Mathematical Formulation of DNA Computation
... By definition (1) and in viewing a DNA sequence as a vector in the format of (9), the following results are obtained. Proposition 2.1: If the base-by-base plus operation of two equal-lengthed numerical value based DNA sequences results in a zero vector, then the two DNA sequences are complementary t ...
... By definition (1) and in viewing a DNA sequence as a vector in the format of (9), the following results are obtained. Proposition 2.1: If the base-by-base plus operation of two equal-lengthed numerical value based DNA sequences results in a zero vector, then the two DNA sequences are complementary t ...
RecA maintains the integrity of chloroplast DNA molecules in
... Although our understanding of mechanisms of DNA repair in bacteria and eukaryotic nuclei continues to improve, almost nothing is known about the DNA repair process in plant organelles, especially chloroplasts. Since the RecA protein functions in DNA repair for bacteria, an analogous function may exi ...
... Although our understanding of mechanisms of DNA repair in bacteria and eukaryotic nuclei continues to improve, almost nothing is known about the DNA repair process in plant organelles, especially chloroplasts. Since the RecA protein functions in DNA repair for bacteria, an analogous function may exi ...
Phosphorus partitioning of soybean lines containing different mutant
... In our previous work (Gillman et al., 2009) we identified a nonsense mutation in one Lpa paralog (Glyma03g32500:lpa1-a; For clarity of presentation in this study, nonsense mutations will be indicated by presence of bold type) and a missense R1039K substitution affecting an ancestrally invariant resi ...
... In our previous work (Gillman et al., 2009) we identified a nonsense mutation in one Lpa paralog (Glyma03g32500:lpa1-a; For clarity of presentation in this study, nonsense mutations will be indicated by presence of bold type) and a missense R1039K substitution affecting an ancestrally invariant resi ...
Unverified Color Pink-eye dilution Ukraine
... According to the inheritance pattern, the “pink-‐eye” phenotype is caused by a single gene. We have started to search for this gene and for the causative mutation, thanks to cheek-‐s ...
... According to the inheritance pattern, the “pink-‐eye” phenotype is caused by a single gene. We have started to search for this gene and for the causative mutation, thanks to cheek-‐s ...
GENETICS accepted
... Crossing over between homologous chromosomes during meiosis promotes genetic diversity by creating new combinations of alleles over generations. Crossovers also create physical connections between the homologs that ensure their proper alignment on the meiotic spindle and subsequent apposite segregat ...
... Crossing over between homologous chromosomes during meiosis promotes genetic diversity by creating new combinations of alleles over generations. Crossovers also create physical connections between the homologs that ensure their proper alignment on the meiotic spindle and subsequent apposite segregat ...
Unit VII - S2TEM Centers SC
... activities and questions are included. This could be used after the introduction of the lesson. ...
... activities and questions are included. This could be used after the introduction of the lesson. ...
North Kitsap High School PAL Program
... artificial selection, describe how natural selection is related to species’ fitness, identify evidence Darwin used to present his case for evolution by natural selection, and state his theory. (16) Explain what a gene pool is, state what determines how a phenotype is expressed, explain how natural s ...
... artificial selection, describe how natural selection is related to species’ fitness, identify evidence Darwin used to present his case for evolution by natural selection, and state his theory. (16) Explain what a gene pool is, state what determines how a phenotype is expressed, explain how natural s ...
Polymorphism of genes encoding PmrAB in colistin
... Objectives: To detect the occurrence of low susceptibility to colistin (polymyxin E), a last-resort antimicrobial, among enterobacteria isolated from samples of animal origin (poultry and swine) and to find out the molecular basis of colistin resistance. Methods: Salmonella enterica and Escherichia ...
... Objectives: To detect the occurrence of low susceptibility to colistin (polymyxin E), a last-resort antimicrobial, among enterobacteria isolated from samples of animal origin (poultry and swine) and to find out the molecular basis of colistin resistance. Methods: Salmonella enterica and Escherichia ...
A NEW TAIL-SHORT MUTATION IN THE MOUSE
... and QH. Here, a very low percentage of tailless mice complete embryonic development and are delivered at parturition (.164/litter). As there were no normaltailed matings of strain C and dba, it is not possible to state definitely that the percentage of normal progeny is reduced. However, 2.94 is ver ...
... and QH. Here, a very low percentage of tailless mice complete embryonic development and are delivered at parturition (.164/litter). As there were no normaltailed matings of strain C and dba, it is not possible to state definitely that the percentage of normal progeny is reduced. However, 2.94 is ver ...
File_details - Harvard PlasmID Database
... In the final clone, if a STOP codon is always present, regardless whether it derives from the target sequence or a nearby universal sequence (such as a cloning linker or the vector), this clone format is called “closed” (Examples C-E). Corollary: If your cloning strategy supplies a STOP codon in a 3 ...
... In the final clone, if a STOP codon is always present, regardless whether it derives from the target sequence or a nearby universal sequence (such as a cloning linker or the vector), this clone format is called “closed” (Examples C-E). Corollary: If your cloning strategy supplies a STOP codon in a 3 ...
biofundamentals - virtual laboratories
... adapted to particular life styles (ecological niches) through a combination of random (stochastic) and non-random events. These evolutionary mechanisms (which we will discuss in some detail) include the origin of mutations, that is, changes that alter the genetic material (double-stranded deoxyribon ...
... adapted to particular life styles (ecological niches) through a combination of random (stochastic) and non-random events. These evolutionary mechanisms (which we will discuss in some detail) include the origin of mutations, that is, changes that alter the genetic material (double-stranded deoxyribon ...
Mutation
In biology, a mutation is a permanent change of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements. Mutations result from damage to DNA which is not repaired or to RNA genomes (typically caused by radiation or chemical mutagens), errors in the process of replication, or from the insertion or deletion of segments of DNA by mobile genetic elements. Mutations may or may not produce discernible changes in the observable characteristics (phenotype) of an organism. Mutations play a part in both normal and abnormal biological processes including: evolution, cancer, and the development of the immune system, including junctional diversity.Mutation can result in several different types of change in sequences. Mutations in genes can either have no effect, alter the product of a gene, or prevent the gene from functioning properly or completely. Mutations can also occur in nongenic regions. One study on genetic variations between different species of Drosophila suggests that, if a mutation changes a protein produced by a gene, the result is likely to be harmful, with an estimated 70 percent of amino acid polymorphisms that have damaging effects, and the remainder being either neutral or weakly beneficial. Due to the damaging effects that mutations can have on genes, organisms have mechanisms such as DNA repair to prevent or correct mutations by reverting the mutated sequence back to its original state.