Clinical trial designs for rare diseases: Studies developed and
... of improving outcomes for patients. The key challenges are organisational and methodological. A multi-disciplinary workshop to review the methods used in ICRI portfolio trials was held in Amsterdam in September 2013. Other as-yet unrealised methods were also discussed. Results: The IRCI trials are e ...
... of improving outcomes for patients. The key challenges are organisational and methodological. A multi-disciplinary workshop to review the methods used in ICRI portfolio trials was held in Amsterdam in September 2013. Other as-yet unrealised methods were also discussed. Results: The IRCI trials are e ...
MedMyst Magazine - Web Adventures
... Edible vaccines that can be given by mouth are also in the works, especially for pathogens that cause diarrhea. Some are quick dissolving films that melt into a liquid and can be swallowed easily. Edible vaccines are being engineered into vegetables, like potatoes and tomatoes, which will produce an ...
... Edible vaccines that can be given by mouth are also in the works, especially for pathogens that cause diarrhea. Some are quick dissolving films that melt into a liquid and can be swallowed easily. Edible vaccines are being engineered into vegetables, like potatoes and tomatoes, which will produce an ...
Medi-Span® Clinical - Clinical Drug Information
... the requirement to implement one clinical decision support rule that is relevant to a high-priority clinical or hospital condition. For example, it can support implementation of a rule based on data elements included in the patient’s medication list, such as duplicate therapy alerts (Medi-Span Clini ...
... the requirement to implement one clinical decision support rule that is relevant to a high-priority clinical or hospital condition. For example, it can support implementation of a rule based on data elements included in the patient’s medication list, such as duplicate therapy alerts (Medi-Span Clini ...
myeloproliferative
... Proliferative disorder of hematopoietic stem cells Well-characterized clinical course ...
... Proliferative disorder of hematopoietic stem cells Well-characterized clinical course ...
Ovarian Cancer Translational Research Initiative Planning Workshop
... and internationally in order to glean a better understanding of the biology of the disease; ultimately to develop mechanisms that will benefit treatment. He introduced some of the existing capacity in Ontario/Canada: the Terry Fox Research Institute Canadian Ovarian Experimental Unified Resource (C ...
... and internationally in order to glean a better understanding of the biology of the disease; ultimately to develop mechanisms that will benefit treatment. He introduced some of the existing capacity in Ontario/Canada: the Terry Fox Research Institute Canadian Ovarian Experimental Unified Resource (C ...
Clinical Expert Submission Template
... drug, DMARD or failure with an anti-TNF-α. Therefore some individuals were entered who might have responded to an anti-TNF-α agent. We do not yet know which patients with psoriasis and psoriatic arthritis are most likely to benefit from ustekinumab. A head-to-head study of ustekinumab vs. an anti-TN ...
... drug, DMARD or failure with an anti-TNF-α. Therefore some individuals were entered who might have responded to an anti-TNF-α agent. We do not yet know which patients with psoriasis and psoriatic arthritis are most likely to benefit from ustekinumab. A head-to-head study of ustekinumab vs. an anti-TN ...
Fig. 1: Process map of HCV screening at Community
... • Majority of people infected with HCV develop chronic infection, which can lead to scarring of the liver and ultimately cirrhosis. • At least 75% of adults infected with HCV are baby boomers, those who were born from 1945 through 1965, when the rates of Hepatitis C infection were high3. • Currently ...
... • Majority of people infected with HCV develop chronic infection, which can lead to scarring of the liver and ultimately cirrhosis. • At least 75% of adults infected with HCV are baby boomers, those who were born from 1945 through 1965, when the rates of Hepatitis C infection were high3. • Currently ...
Medicine 2 - Learning objectives
... Toxicology – General Approach 1) Have an approach for risk assessment and prediction of toxicity in overdose 2) Understand additional treatment options are available for some drugs including decontamination options; enhanced elimination and the use of antidotes 3) Be able to recognise and manage acu ...
... Toxicology – General Approach 1) Have an approach for risk assessment and prediction of toxicity in overdose 2) Understand additional treatment options are available for some drugs including decontamination options; enhanced elimination and the use of antidotes 3) Be able to recognise and manage acu ...
Levodopa-Carbidopa Intestinal Gel
... (51.6%) were ongoing, and 24 (12.5%) had withdrawn from the study. Among 166 cases observed at week-12, mean OFF time decreased by 3.9 hours/day, a benefit that was maintained in 61 patients rem aining at week-54 (mean reduction in OFF time of 4.6 hours/day). The mean ‘ON time without troublesome dy ...
... (51.6%) were ongoing, and 24 (12.5%) had withdrawn from the study. Among 166 cases observed at week-12, mean OFF time decreased by 3.9 hours/day, a benefit that was maintained in 61 patients rem aining at week-54 (mean reduction in OFF time of 4.6 hours/day). The mean ‘ON time without troublesome dy ...
See the story in Newport Beach Magazine
... “These are exciting times to be a patient and a surgeon,” says Dr. Juris Bunkis of Orange County Plastic Surgery in Newport Beach. The current, most popular treatment his patients come in for? “Thermigen Radiofrequency, which is minimally invasive, is a treatment designed to tighten skin, and it is ...
... “These are exciting times to be a patient and a surgeon,” says Dr. Juris Bunkis of Orange County Plastic Surgery in Newport Beach. The current, most popular treatment his patients come in for? “Thermigen Radiofrequency, which is minimally invasive, is a treatment designed to tighten skin, and it is ...
chronic obstructive pulmonary disease clinical
... respiratory infections in childhood, and other respiratory diseases. Family history of COPD or other chronic respiratory disease (such as asthma or CF). Pattern of symptom development. Typically develops in adult life and most patients are conscious of increased breathlessness, prolonged “winter ...
... respiratory infections in childhood, and other respiratory diseases. Family history of COPD or other chronic respiratory disease (such as asthma or CF). Pattern of symptom development. Typically develops in adult life and most patients are conscious of increased breathlessness, prolonged “winter ...
Antibiotics
... He came back to his lab from vacation and notice a mold growing in the middle of a petri dish culture and a ring around the mold were no bacteria grew He called the chemical produced by the Penicillium mold ...
... He came back to his lab from vacation and notice a mold growing in the middle of a petri dish culture and a ring around the mold were no bacteria grew He called the chemical produced by the Penicillium mold ...
Types II and III: Antibody-Mediated and Antigen
... may affect the skin, joints, kidneys, brain, and other organs. Causes, incidence, and risk factors Systemic lupus erythematosus (SLE) is an autoimmune disease, which means the body's immune system mistakenly attacks healthy tissue. This leads to long-term (chronic) inflammation. The underlying cause ...
... may affect the skin, joints, kidneys, brain, and other organs. Causes, incidence, and risk factors Systemic lupus erythematosus (SLE) is an autoimmune disease, which means the body's immune system mistakenly attacks healthy tissue. This leads to long-term (chronic) inflammation. The underlying cause ...
Caprion Biosciences to Lead Short Course and Present Poster at
... Montreal, QC, Canada – Feb 17th, 2017/ - Caprion Biosciences Inc. announced today that Dr. Yoav Peretz, Scientific Director of ImmuneCarta will lead a short course on novel techniques in development of Intracellular cytokine detection assays in adoptive cell therapy trials at the annual Molecular Me ...
... Montreal, QC, Canada – Feb 17th, 2017/ - Caprion Biosciences Inc. announced today that Dr. Yoav Peretz, Scientific Director of ImmuneCarta will lead a short course on novel techniques in development of Intracellular cytokine detection assays in adoptive cell therapy trials at the annual Molecular Me ...
Monoclonal Antibodies as a novel class of cancer therapeutics
... Abs belong to a well-established drug class that has a high success rate from the first use in humans to regulatory approval: 29% for chimeric Abs, 25% for humanized Abs (only 11% small-molecule drug). Abs are generally well tolerated by humans, although infusion reaction (first dose) are common but ...
... Abs belong to a well-established drug class that has a high success rate from the first use in humans to regulatory approval: 29% for chimeric Abs, 25% for humanized Abs (only 11% small-molecule drug). Abs are generally well tolerated by humans, although infusion reaction (first dose) are common but ...
MR Imaging in White Matter Diseases of the Brain and Spinal Cord
... The strength of the book lies in the clinical imaging and its description. Charles Raybaud, on MR imaging of brain development, describes the problems involved in imaging premature and term infants in addition to presenting sound material on fetal brain imaging and developing/maturation of white mat ...
... The strength of the book lies in the clinical imaging and its description. Charles Raybaud, on MR imaging of brain development, describes the problems involved in imaging premature and term infants in addition to presenting sound material on fetal brain imaging and developing/maturation of white mat ...
The Music Never Stops
... DVAX and SGMO. In the meantime, more deals are being struck. Actavis is buying Durata (DRTX), a specialty drug maker – for $675 million plus more on sales milestones – which is expected to strengthen its business that focuses on infectious diseases. In our view, this bodes well for MTSL Recommendati ...
... DVAX and SGMO. In the meantime, more deals are being struck. Actavis is buying Durata (DRTX), a specialty drug maker – for $675 million plus more on sales milestones – which is expected to strengthen its business that focuses on infectious diseases. In our view, this bodes well for MTSL Recommendati ...
Pompe Disease - Muscular Dystrophy Association of New Zealand
... Mutation Analysis (looking at the gene to see the precise error) can also be used to confirm a diagnosis and to test other family members if indicated. GENETICS Pompe Disease is an inherited disease caused by a defect in the gene which tells the body how to make GAA. We each have two copies of this ...
... Mutation Analysis (looking at the gene to see the precise error) can also be used to confirm a diagnosis and to test other family members if indicated. GENETICS Pompe Disease is an inherited disease caused by a defect in the gene which tells the body how to make GAA. We each have two copies of this ...
Highlights in Breast Cancer From the 2016 American Society of
... in women with metastatic breast cancer. PFS did improve, however, among the patients who mounted an immune response to the vaccine. The OPT-822 vaccine consists of globo H, covalently linked to the carrier protein KLH (keyhole limpet hemocyanin), and a saponin-based adjuvant. Globo H is a carbohydra ...
... in women with metastatic breast cancer. PFS did improve, however, among the patients who mounted an immune response to the vaccine. The OPT-822 vaccine consists of globo H, covalently linked to the carrier protein KLH (keyhole limpet hemocyanin), and a saponin-based adjuvant. Globo H is a carbohydra ...
1st Bulgarian ICD Registry
... All the 7 deaths were not device related 3 device related hospitalizations required minor surgery All shock-therapies were successful Antitachypacing was successful 70% of the times (painless Rx) ...
... All the 7 deaths were not device related 3 device related hospitalizations required minor surgery All shock-therapies were successful Antitachypacing was successful 70% of the times (painless Rx) ...
Dissemination and Implementation - Coordinating Center for Clinical
... ALLHAT Delineation of Core Messages Because of the superiority of thiazide-type diuretics in preventing one or more major forms of CVD and their lower cost, they should be the drug of choice for first step antihypertensive therapy. For the patient who cannot take a diuretic (which should be an unus ...
... ALLHAT Delineation of Core Messages Because of the superiority of thiazide-type diuretics in preventing one or more major forms of CVD and their lower cost, they should be the drug of choice for first step antihypertensive therapy. For the patient who cannot take a diuretic (which should be an unus ...
Faculty of Infectious and Tropical Diseases
... collaborations addressing these issues in Tanzania, Zambia, Uganda and South Africa. Brian Greenwood FRS is leading an initiative to strengthen malaria research in the School through new collaborative links in Africa. Research and teaching on blinding diseases in developing countries has been greatl ...
... collaborations addressing these issues in Tanzania, Zambia, Uganda and South Africa. Brian Greenwood FRS is leading an initiative to strengthen malaria research in the School through new collaborative links in Africa. Research and teaching on blinding diseases in developing countries has been greatl ...