Anti-Emetic Guidelines For Chemotherapy Patients
... Dexamethasone should be routinely given IV pre chemotherapy and should also be given routinely post highly emetogenic chemotherapy – recommended maximum 8mg per day. Where patients are intolerant of steroids or are on high dose prednisolone following chemotherapy - Dexamethasone should be omitted. ...
... Dexamethasone should be routinely given IV pre chemotherapy and should also be given routinely post highly emetogenic chemotherapy – recommended maximum 8mg per day. Where patients are intolerant of steroids or are on high dose prednisolone following chemotherapy - Dexamethasone should be omitted. ...
... The physical properties of inflammation are redness, heat, swelling and pain which are caused by the influx of leukocytes to the affected area. Chemokines are a type of signalling molecule which recruits leukocytes to the area of infection through the process of chemotaxis. Chemokines are therefore ...
Anithypertensive_drugs_and_its_classifications
... osmotic effect that inhibits the reabsorption of water. ◦ This effect can also be seen if blood plasma levels of glucose become very high (e.g. in hyperglycaemic episodes experienced by individuals with diabetes mellitus). The glucose that remains unabsorbed inhibits the reabsorption of water and la ...
... osmotic effect that inhibits the reabsorption of water. ◦ This effect can also be seen if blood plasma levels of glucose become very high (e.g. in hyperglycaemic episodes experienced by individuals with diabetes mellitus). The glucose that remains unabsorbed inhibits the reabsorption of water and la ...
What is mental life
... ii. Inactivation of methionine synthetase (cannot be given to CA pts) d. SE = cerebral vasodilation (↑ ICP midly) ...
... ii. Inactivation of methionine synthetase (cannot be given to CA pts) d. SE = cerebral vasodilation (↑ ICP midly) ...
Lecture 7 - Antidepressants new 11-12
... Too long (3-11 days): Fluoxetine (Prozac) Moderate length (~24hr): Sertraline, Paroxetine, Citalopram. Metabolism: P450 then conjugation They are enzyme inhibitors Weak inhibitors < Sertraline, Citalopram interaction Strong inhibitors > Fluoxetine, Paroxetine metabolism of TCA, neurolep ...
... Too long (3-11 days): Fluoxetine (Prozac) Moderate length (~24hr): Sertraline, Paroxetine, Citalopram. Metabolism: P450 then conjugation They are enzyme inhibitors Weak inhibitors < Sertraline, Citalopram interaction Strong inhibitors > Fluoxetine, Paroxetine metabolism of TCA, neurolep ...
02 02
... the amino group, and the beta-hydroxyl group in a fashion resembling that of (-)-(R)-NE. ...
... the amino group, and the beta-hydroxyl group in a fashion resembling that of (-)-(R)-NE. ...
PowerPoint
... agonist effect at one receptor and an antagonist effect at another receptor. These are useful in treating opioid dependency because they limit withdrawal symptoms to some degree. Example: Nubain Partial Agonist: Drug that binds to opioid receptors but has a low intrinsic activity (low efficacy). E ...
... agonist effect at one receptor and an antagonist effect at another receptor. These are useful in treating opioid dependency because they limit withdrawal symptoms to some degree. Example: Nubain Partial Agonist: Drug that binds to opioid receptors but has a low intrinsic activity (low efficacy). E ...
Allergy and Immunology Review Corner: Chapter 87 of
... 2. H1-antihistamines decrease the size of the wheal and/or flare by which mechanisms? A. Inhibiting histamine synthesis in mast cells. B. Increasing leakage of plasma protein. C. Blocking the histamine-induced axon reflex. ...
... 2. H1-antihistamines decrease the size of the wheal and/or flare by which mechanisms? A. Inhibiting histamine synthesis in mast cells. B. Increasing leakage of plasma protein. C. Blocking the histamine-induced axon reflex. ...
ABC of palliative care : Nausea, vomiting, and intestinal obstruction
... Explanation and reassurance, possibly also anxiolytic drugs ...
... Explanation and reassurance, possibly also anxiolytic drugs ...
Pharmacology of Muscarinic Receptor Blockade
... Muscarinic receptor blockade does not interfere with transmission at autonomic ganglionic sites, the adrenal medulla, or skeletal muscle fibers. Sympathetic adrenergic functions are not affected. ...
... Muscarinic receptor blockade does not interfere with transmission at autonomic ganglionic sites, the adrenal medulla, or skeletal muscle fibers. Sympathetic adrenergic functions are not affected. ...
General Anesthesia
... Action of anesthetics on the GABAA receptor Binding of anesthetics to specific sites on the receptor protein Proof of this mechanism is through point ...
... Action of anesthetics on the GABAA receptor Binding of anesthetics to specific sites on the receptor protein Proof of this mechanism is through point ...
Antiemetic Guidelines for Adult Patients Receiving Chemotherapy
... The purpose of this document is to provide guidance on the rationale use of antiemetics for prevention and treatment of chemotherapy and radiotherapy induced nausea and vomiting in adult patients. They are not intended to address nausea and vomiting in palliative care. These guidelines are intended ...
... The purpose of this document is to provide guidance on the rationale use of antiemetics for prevention and treatment of chemotherapy and radiotherapy induced nausea and vomiting in adult patients. They are not intended to address nausea and vomiting in palliative care. These guidelines are intended ...
N receptor agonists
... Ligand-gated Ion Channels • At the NMJ, N receptors Pentameric with four types of subunits, two a subunits bind ACh for ligand gating • All other nAChRs, including those at the peripheral ganglia, have 2 a’s and 3 b’s ...
... Ligand-gated Ion Channels • At the NMJ, N receptors Pentameric with four types of subunits, two a subunits bind ACh for ligand gating • All other nAChRs, including those at the peripheral ganglia, have 2 a’s and 3 b’s ...
DRUGS AFFECTING THE RESPIRATORY SYSTEM
... Involves combined use of antihistamines, nasal decongestants, antitussives, and expectorants Treatment is “empiric therapy,” treating the most likely cause Antivirals and antibiotics may be used, but a definite viral or bacterial cause may not be easily identified ...
... Involves combined use of antihistamines, nasal decongestants, antitussives, and expectorants Treatment is “empiric therapy,” treating the most likely cause Antivirals and antibiotics may be used, but a definite viral or bacterial cause may not be easily identified ...
Spare Receptors
... with a diuretic drug. Drugs X and Y have the same mechanism of diuretic action. Drug X in a dose of 5 mg produces the same magnitude of diuresis as 500 mg of drug Y. This suggests that: Drug Y is less efficacious than drug X Drug X is about 100 times more potent than drug Y Toxicity of drug X is les ...
... with a diuretic drug. Drugs X and Y have the same mechanism of diuretic action. Drug X in a dose of 5 mg produces the same magnitude of diuresis as 500 mg of drug Y. This suggests that: Drug Y is less efficacious than drug X Drug X is about 100 times more potent than drug Y Toxicity of drug X is les ...
Dose-Response Concept
... cocaine and ethanol has pharmacological properties similar to those of cocaine but with a longer duration in the blood plasma (three to five times as long). ...
... cocaine and ethanol has pharmacological properties similar to those of cocaine but with a longer duration in the blood plasma (three to five times as long). ...
Health Canada - Isomer Design
... Canadian Status: JWH-175 and JWH-072 are not listed in the Schedules to the CDSA. JWH175 has been reported to bind to the CB1 cannabinoid receptor whereas JWH-072 has an affinity for both the CB1 and CB2 cannabinoid receptors1. However, the efficacy of these two substances as cannabinoid receptor ag ...
... Canadian Status: JWH-175 and JWH-072 are not listed in the Schedules to the CDSA. JWH175 has been reported to bind to the CB1 cannabinoid receptor whereas JWH-072 has an affinity for both the CB1 and CB2 cannabinoid receptors1. However, the efficacy of these two substances as cannabinoid receptor ag ...
PIO Nas - Badan Pengawas Obat dan Makanan
... Vomiting induced by administration of cisplatin in ferrets was suppressed by oral administration of this product. The effect was potent and sustained.
Carcinostatics drugs such as cisplatin cause enterochromaffin cells in the gastrointestinal tract to release serotonin. The
rel ...
... Vomiting induced by administration of cisplatin in ferrets was suppressed by oral administration of this product. The effect was potent and sustained.
Drugs Affecting the Gastrointestinal System and Nutrition
... Act by coating the walls of the GI tract. Bind with the causative bacteria or toxin to their adsorbent surface for elimination through the stool. ...
... Act by coating the walls of the GI tract. Bind with the causative bacteria or toxin to their adsorbent surface for elimination through the stool. ...
DRUGS AFFECTING THE RESPIRATORY SYSTEM
... Involves combined use of antihistamines, nasal decongestants, antitussives, and expectorants Treatment is “empiric therapy,” treating the most likely cause Antivirals and antibiotics may be used, but a definite viral or bacterial cause may not be easily identified ...
... Involves combined use of antihistamines, nasal decongestants, antitussives, and expectorants Treatment is “empiric therapy,” treating the most likely cause Antivirals and antibiotics may be used, but a definite viral or bacterial cause may not be easily identified ...
PowerPoint - Pitt Honors Human Physiology
... • These drugs are fairly selective for PDE5, but there are limited actions on other enzymes. For example, Sildenafil is only about 10-fold as potent for PDE5 compared to PDE6, an enzyme found in the retina; this cross reactivity is thought to be the basis for abnormalities related to color vision o ...
... • These drugs are fairly selective for PDE5, but there are limited actions on other enzymes. For example, Sildenafil is only about 10-fold as potent for PDE5 compared to PDE6, an enzyme found in the retina; this cross reactivity is thought to be the basis for abnormalities related to color vision o ...
JV Poster Barcelona 2012
... activity (a concomitant effect on the NMDA- and AMPA–receptors) against monofunctional drugs: the low-affinity NMDA receptor blocker memantine and the positive AMPA receptor modulator QQX. New bio-isosteric analogues of MK-801 (IPAC 1-5) were synthesized and designed to have bifunctional activity. L ...
... activity (a concomitant effect on the NMDA- and AMPA–receptors) against monofunctional drugs: the low-affinity NMDA receptor blocker memantine and the positive AMPA receptor modulator QQX. New bio-isosteric analogues of MK-801 (IPAC 1-5) were synthesized and designed to have bifunctional activity. L ...
5-HT3 antagonist
The 5-HT3 antagonists, informally known as ""setrons"", are a class of drugs that act as receptor antagonists at the 5-HT3 receptor, a subtype of serotonin receptor found in terminals of the vagus nerve and in certain areas of the brain.With the notable exception of alosetron and cilansetron, which are used in the treatment of irritable bowel syndrome, all 5-HT3 antagonists are antiemetics, used in the prevention and treatment of nausea and vomiting. They are particularly effective in controlling the nausea and vomiting produced by cancer chemotherapy and are considered the gold standard for this purpose.The 5-HT3 antagonists may be identified by the suffix –setron, and are classified under code A04AA of the WHO's Anatomical Therapeutic Chemical Classification System.