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CHAPTER 12 MUSCULAR SYSTEM BEHAVIORAL OBJECTIVES 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. List the functions of skeletal muscle. [12.1, p.226] Describe the anatomy of a whole muscle. [12.1, pp.226-227, Fig. 12.2] Describe muscular attachments and antagonistic pairs. [12.1, p.227, Fig. 12.3] Name the major muscles of the body, and know their actions. [12.1, p.228, Fig. 12.4, Tables 12.1 & 12.2] Describe the anatomy of a muscle fiber. [12.1, p.226 & p.231, Figs. 12.2 & 12.5] Explain how the sarcomere shortens during muscle contraction. [12.2, pp.230-231, Fig. 12.5] Describe the neuromuscular junction, and explain how impulses are transferred to the muscle sarcolemma. [12.2, p.232, Fig. 12.7] Explain the role of calcium in muscle contraction. [12.2, p. 233, Fig. 12.8] Describe the basic laboratory observations on whole muscle contraction. [12.3, p.234, Fig. 12.9] Explain how muscle tone is maintained. [12.3, p.234] Describe the benefits of physical exercise. [12.3, Health Focus, p.235] List the energy sources available within a muscle fiber, and explain the circumstances in which each is used. [12.4, pp.236-239, Fig. 12.10] Discuss the events leading to oxygen debt. [12.4, p.236, Fig. 12.10] Describe how exercise can increase muscle size. [12.4, p.238] Contrast the functions of slow-twitch and fast-twitch fibers. [12.4, p.238, Fig. 12.11] List a number of muscular disorders. [12.4, p. 240, Fig. 12.12] Discuss how the muscular system works with other body systems to maintain homeostasis. [12.5, p.240-241, Human Systems Work Together] Describe the role of the muscular system in homeostasis. [12.5, p.240-241] Understand and use the bold-faced and italicized terms included in this chapter. [Understanding Key Terms, p.243] EXTENDED LECTURE OUTLINE 12.1 Skeletal Muscles Muscles have various functions. Skeletal muscles maintain posture, cause movement, produce heat, and assist in movement within cardiovascular and lymphatic vessels. The contraction of cardiac muscle causes the heart to pump blood. The contraction of smooth muscle propels food in the digestive tract and urine in the ureters. The Structure of Muscles Skeletal muscles are covered by fascia that extends beyond their ends as tendons. A muscle fiber contains many contractile structures called myofibrils. Muscles Work in Pairs The origin of a muscle is the end attaching to the immovable bone; the insertion of a muscle is the end attaching to the movable bone. Muscles are frequently grouped as synergists and antagonists. The muscle that works hardest is the prime mover. Skeletal Muscles of the Body Skeletal muscles are named according to their size, shape, location, direction of fibers, number of attachments, or action. Names and functions of the major muscles of the body are listed in Tables 12.1 and 12.2. Mader VRL CD-ROM Image 0225l.jpg (Fig. 12.1) Image 0226l.jpg (Fig. 12.2) Image 0227l.jpg (Fig. 12.3) Image 0228al.jpg (Fig. 12.4) Image 0228bl.jpg (Fig. 12.4) 62 Mader VRL CD-ROM, con’t. Image 0228cl.jpg (Fig. 12.4) Image 0228dl.jpg (Fig. 12.4) Image 0228el.jpg (Fig. 12.4) Image 0228fl.jpg (Fig. 12.4) Dynamic Human 2.0 CD-ROM Muscular/Anatomy/Body Regions Muscular/Anatomy/Cardiac Muscle Muscular/Anatomy/Skeletal Muscle Muscular/Anatomy/Smooth Muscle Muscular/Explorations/Muscle Action Around a Joint Life Science Animations VRL 2.0 Muscular/Clinical Concepts/MRI of Rotator Cuff Animal Biology/Support and Movement/ How a Muscle Moves Mader ESP Modules Online Animals/Support and Locomotion/Muscles Transparencies 169 (Fig. 12.2) 170 (Fig. 12.3) 171 (Fig. 12.4a) 172 (Fig. 12.4b) 12.2 Mechanism of Muscle Fiber Contraction Overview of Muscular Contraction The plasma membrane of a muscle fiber is its sarcolemma. Its endoplasmic reticulum is called the sarcoplasmic reticulum, which stores calcium. The sarcolemma invaginates into T tubules that contact the sarcophasmic reticulum. Within muscle fibers are the contractile myofibrils. Myofibrils and Sarcomeres Myofibrils are cylindrical structures within muscle fibers. Myofilaments that make up myofibrils are arranged such that they exhibit striations. Striations are grouped into contractile units called sarcomeres. Within sarcomeres, thick filaments are made up of myosin, and thin filaments are made up of actin. Sliding Filaments When a nervous impulse reaches a muscle fiber, the sarcoplasmic reticulum releases its stored calcium, and the fiber contracts. The myosin filaments have cross-bridges that pull on the actin myofilaments, causing them to slide past each other. The sliding filament theory states that the filaments do not change in length as the sarcomere shortens. Muscle Innervation The region where a motor neuron contacts a muscle fiber is called the neuromuscular junction. A motor nerve fiber expands into a synaptic end bulb as it approaches a muscle fiber. When a nerve impulse travels down the neuron, synaptic vesicles storing a neurotransmitter acetylcholine (ACh) move to the end of the bulb, releasing the ACh into the synaptic cleft. The muscle fiber receives the neurotransmitter at receptor sites. The sarcolemma generates impulses that travel over the sarcolemma to the T tubules and sarcoplasmic reticulum. Stored calcium is released to the cell, triggering contraction. Two proteins, troponin and tropomyosin, occur in conjunction with the actin filaments. Calcium binds with the troponin, exposing a myosin-binding site. Myosin cross-bridges bind to the revealed site on the actin filaments. ATP supplies energy to form the cross-bridges. When ADP + P are released from mysoin, the cross-bridges change their position and pull the thin filaments toward the middle of the sarcomere. 63 Mader VRL CD-ROM Image 0229al.jpg (Fig. 12.5) Image 0229bl.jpg (Fig. 12.5) Image 0229cl.jpg (Fig. 12.5) Image 0230l.jpg (Fig. 12.6) Image 0231l.jpg (Fig. 12.7) Image 0232al.jpg (Fig. 12.8) Image 0232bl.jpg (Fig. 12.8) Dynamic Human 2.0 CD-ROM Muscular/Explorations/Neuromuscular Junction Muscular/Explorations/Sliding Filament Theory Muscular/Histology/Cardiac Muscle Muscular/Histology/Smooth Muscle Muscular/Histology/Skeletal Muscle: Cross-Section Muscular/Histology/Skeletal Muscle:Longitudinal Muscular/Histology/Neuromuscular Junction Life Science Animations VRL 2.0 Animal Biology/Support and Movement/ Contraction of a Muscle Animal Biology/Support and Movement/ Role of Calcium and Myosin and Muscle Contraction Animal Biology/Support and Movement/ Striated Muscle Contraction Animal Biology/Support and Movement/ Muscle Contraction Action Potential Animal Biology/Support and Movement/ Detailed Striated Muscle Contraction Animal Biology/Support and Movement/ Actin-Myosin Crossbridges Mader ESP Modules Online Animals/Support and Locomotion/Muscle Cell Function Transparencies 173 (Fig. 12.5) 174 (Fig. 12.7) 175 (Fig. 12.8a) 176 (Fig. 12.8b) 12.3 Whole Muscle Contraction Basic Laboratory Observations A myogram is the visual pattern generated from the recorded contraction of a muscle. A muscle twitch or single contraction is divided into a latent period, a period of contraction, and a relaxation period. When a muscle receives a rapid series of stimuli, it cannot relax between contractions. It contracts (summates) until it reaches a sustained contraction, called tetanus. Muscle Tone in the Body Muscle tone results when portions of muscles are contracting while other portions relax. Maintenance of muscle tone requires receptors called muscle spindles. Recruitment and the Strength of Contraction When a nervous impulse is received, all muscle fibers within the motor neuron contract together in a motor unit. When more impulses are received, more motor units within a muscle contract (recruitment). Mader VRL CD-ROM Image 0233l.jpg (Fig. 12.9) Transparencies 177 (Fig. 12.9) 64 12.4 Energy for Muscle Contraction ATP can be supplied to muscle in three different ways: One anaerobic pathway uses creatine phosphate to regenerate ATP. A second anaerobic pathway, fermentation, provides energy without using oxygen. Fermentation ends with lactic acid, which changes muscle pH, leading to fatigue. Aerobic respiration supplies muscles with most of their energy. In people that exercise regularly, the number of mitochondria per muscle cell increases. Oxygen Debt Oxygen debt occurs when cells have used up available supplies of oxygen. Repaying oxygen debt means replenishing creatine phosphate and converting lactic acid back to pyruvate. Athletes and Muscle Contraction Exercise and Size of Muscles Atrophy occurs when muscles are unused. Forceful exercise (weight lifting) increases the number of myofibrils in a muscle, leading to hypertrophy. Slow-Twitch and Fast-Twitch Muscle Fibers Slow-twitch fibers have more endurance and supply their energy aerobically. Fast-twitch fibers are anaerobic and designed for strength but not endurance. They can develop maximum tension rapidly but fatigue quickly. Muscular Disorders Tendonitis occurs when a tendon is inflamed and painful, and is due to physical strain. Muscular dystrophy is a group of disorders in which there is a progressive degeneration of muscles. Myasthenia gravis is an autoimmune disease in which antibodies destroy acetylcholine receptors. Muscular cramps and spasms are annoying, but not serious, muscular disorders. Mader VRL CD-ROM Image 0234l.jpg (Fig. TA12.1) Image 0235l.jpg (Fig. TA12.2) Image 0236l.jpg (Fig. TA12.3) Image 0237al.jpg (Fig. 12.10) Image 0237bl.jpg (Fig. 12.10) Image 0237cl.jpg (Fig. 12.10) Image 0238l.jpg (Fig. 12.11) Image 0239l.jpg (Fig. 12A) Image 0240l.jpg (Fig. 12.12) Dynamic Human 2.0 CD-ROM Muscular/Explorations/Contraction: Isometric/Isotonic Case Studies Online Sports and Fitness Transparencies 178 (Fig. 12.10) 179 (Fig. 12.11) 12.5 Homeostasis The Human Systems Work Together box illustrates how the muscular system works with other body systems to maintain homeostasis. Mader VRL CD-ROM Image 0241al.jpg (Fig. TA12.4) Image 0241bl.jpg (Fig. TA12.4) Image 0242l.jpg (Fig. TA12.5) Transparencies 180 (Fig. TA12.1) 181 (Fig. TA12.2) 65 SEVENTH EDITION CHANGES New/Revised Text: This was chapter 11 in the previous edition. 12.4 Energy for Muscle Contraction introductory paragraphs have been rewritten for clarity. The discussion entitled Muscular Disorders is completely new and discusses muscle spasms and cramps, tendonitis, tetanus, muscular dystrophy, and myasthenia gravis. New/Revised Figures: 12.7 Neuromuscular junction; 12.12 Myasthenia gravis. STUDENT ACTIVITIES Physical Therapy As a Career 1. Invite a physical therapist or PTA to your classroom. Ask them to discuss the educational and vocational requirements needed to become a physical therapist or PTA. Then ask them to describe the types of physical therapy they use for different types of patients. Have them explain what activities they might do during a typical day and invite students to ask questions. Athletic Department Weight Room 2. Take your students to your local Althetic Department weight room and have an athletic trainer show some of the muscle-building exercises that aer suggested for different sports. Have them show your students how to work different muscle groups, being sure to name muscles and discuss how muscles work in groups. Exercise Specialist 3. Ask a campus coach, athletic trainer, or aerobic dance instructor to come to your class and discuss the importance of aerobic exercise. Request that the speaker includes such topics as: what type of exercise to begin if you do not exercise at all; the importance of stretching, as well as types and duration of stretches before and after exercise; the need for a minimum of 20 minutes of aerobic activity; how to determine whether you are achieving aerobic activity; and muscle toning. Demonstrations are useful for this topic. Include a discussion of Table 12A, “A Checklist for Staying Fit”. 66