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The Role of the Tripartite Glutamatergic Synapse in the Pathophysiology
of Alzheimer#cod#x02019;s Disease
Carolyn C. Rudy 1 ;Holly C. Hunsberger 1 ;Daniel S. Weitzner 1 ;Miranda N. Reed;
1 Behavioral Neuroscience, Department of Psychology, ;
Figure 3. Tau-mediated excitotoxicity. A In healthy neurons, tau transports Fyn to the dendritic spine where Fyn, a tyrosine kinase that phosphorylates the NR2B receptor
subunit Tyr 1472 , stabilizes the NR2B:PSD95 complex. B In the presence of A#cod#x003b2; andor hyperphosphorylated tau ptau, stabilization of the NR2B:PSD95 complex
enhances glutamatergic excitotoxicity. C Removal of tau or Fyn prevents glutamatergic excitotoxicity mediated by A#cod#x003b2;.
Aging and Disease,null,null(null),null-null. Doi:10.14336/AD.2014.04.23
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