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Functions of Muscles • 1. Produce movement – all movements of the human body are produced by muscles • 2. Maintain posture – some muscles are in a partial state of contraction at all times • 3. Stabilize joints – muscle tendons reinforce and stabilize joints • 4. Generate heat – ¾ of the energy used to contract muscles is lost as heat. Needed to maintain body temperature Skeletal Muscle Characteristics • • • • • Most are attached by tendons to bones Cells are multinucleate Striated – have visible banding Voluntary – subject to conscious control Cells are surrounded and bundled by connective tissue called Fascia Smooth Muscle Characteristics • • • • • Has no striations Spindle-shaped cells Single nucleus Involuntary – no conscious control Found mainly in the walls of hollow organs Cardiac Muscle Characteristics • Has striations • Usually has a single nucleus • Joined to another muscle cell at an intercalated disc • Involuntary • Found only in the heart General Structure of Muscles • A muscle is composed of bundles of muscle fibers called fascicles separated by connective tissue (perimysium) • Fascicles are surrounded by a tough connective tissue layer called the Epimysium, which covers the entire muscle • The epimysia extend beyond the end of the muscle and form the Tendon which connects it to bone • The epimysia can also form a broad sheet-like connection to an adjacent muscle called an Aponeurosis • Each fasciculi is composed of bundles of smaller fibers that are the individual muscle cells. • Each cell is composed of smaller fibers called myofibrils surrounded by a cell membrane (sarcolemma) • The myofibrils are made of filaments of actin and myosin protein arranged in units called sarcomeres Neuromuscular Junction • Sarcolemma is folded to form the motor end plate. Many Mitochondria in the region • Nerve fiber forms Synaptic Clefts into the recesses of the sarcolemma. The nerve contains synaptic vesicles that contain neurotransmitter • When a nerve impulse reaches the junction it causes the release of the neurotransmitters • The specific neurotransmitter that stimulates skeletal muscle cells is acetylcholine Skeletal Muscle Contraction • 1. Nerve impulse causes the release of acetylcholine by the synaptic vessels into the synaptic cleft • 2. The acetylcholine stimulates a muscle impulse along the length of the sarcolemma • 3. The impulse cause the sarcoplasmic reticulum to release Calcium ions into the sarcoplasm of the muscle cell • 4. Ca++ ions cause an attractive force between actin and myosin and the sarcomere becomes shorter • 5. Ca++ ions are removed by active transport and acetylcholine is decomposed by an enzyme Energy for Contractions • Energy for the contraction comes from ATP. ATP→ADP + Energy • 4 – 6 seconds worth of ATP is stored in muscles • Another 20 seconds worth can be generated from Creatine Phosphate • The rest must be generated via aerobic and anaerobic respiration. • Aerobic respiration is slow but efficient (36 ATP per molecule of glucose • Anaerobic respiration is fast but inefficient (2 ATP per glucose molecule) • Muscle Fatigue - Muscle loses the ability to contract. Due mainly to the buildup of lactic acid from anaerobic respiration • Myoglobin – Reddish brown pigment found in muscles that combines with oxygen to store it in muscles • Cramps – Muscle contracts but does not relax. Caused by lack of ATP. Can’t move Ca++ ions out. • Muscle Tone – Sustained contraction that occurs in some fibers of most muscles. Maintains Posture. Involuntary • Twitch Contraction – Quick contraction (fraction of a second) in response to a single stimulus. Example - Eye blink • Tetanic Contraction – Sustained contraction in response to continuous stimuli. Most muscle contractions are tetanic. • Origin – Point of attachment to the immovable or less movable bone. • Insertion – Point of attachment to the movable bone • Muscle Atrophy – Decrease in the size of the muscle due to disuse • Muscle Hypertrophy – Increase in the size of muscles from exercise • Muscles Act In Groups • Prime mover – is responsible for most of a certain movement • Synergist – assist the prime mover • Antagonist – capable of resisting the prime mover’s action. Responsible for movement in the opposite direction.