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Unit 7 Objectives 1. Describe the properties and functions of muscle tissue. (p. 178) 2. Describe the organization of muscle at the tissue level. (p. 178) 3. Identify the structural components of a sarcomere. (pp. 179–182) 4. Explain the key steps involved in the contraction of a skeletal muscle fiber. (pp. 182–184) 5. Compare the different types of muscle contractions. (pp. 187–189) 6. Describe the mechanisms by which muscles obtain and use energy to power contractions. (pp. 189–192) 7. Relate types of muscle fibers to muscular performance. (pp. 193–195) 8. Distinguish between aerobic and anaerobic endurance and explain their implications for muscular performance. (p. 192) 9. Contrast skeletal, cardiac, and smooth muscles in terms of structure and function. (pp. 194–195) 10. Identify the principal axial muscles of the body together with their origins and insertions. (pp. 199–204) 11. Identify the principal appendicular muscles of the body, together with their origins and insertions. (pp. 204–216) 12. Describe the effects of exercise and aging on muscle tissue. (p. 216) Unit 7 1. Describe the properties and functions of muscle tissue. (p. 178) Unit 7 1. Describe the properties and functions of muscle tissue. (p. 178) The integrated action of joints, bones, nerves and skeletal muscles… • Produces movements such as walking, running, facial expressions, eye movements, and respiration. • Maintains posture, joint stability. • Supports, protect and encloses vital organs. • Helps to maintain body temperature by producing heat. • Guards the “gates” into and out of our bodies (ex. The iris of the eye). Unit 7 2. Describe the organization of muscle at the tissue level. (p. 178) Muscle Organization I Muscle Organization II Muscle Organization III Unit 7 2. Describe the organization of muscle at the tissue level. (p. 178) Movement is attained due to a muscle moving an attached bone. * DUH! * Origin * Muscle Contracting * Tendon * Insertion Unit 7 2. Describe the organization of muscle at the tissue level. (p. 178) * Bone * Perimysium * Blood Vesseles *Muscle Fiber *Fascicle *Tendon *Epimysium *Endomysium Gross Anatomy of Skeletal Muscle Unit 7 3. Identify the structural components of a sarcomere. (pp. 179–182) Unit 7 3. Identify the structural components of a sarcomere. (pp. 179–182) * Sarcomere } * sarcolemma } * Myofibril * Nuclei Unit 7 3. Identify the structural components of a sarcomere. (pp. 179–182) Myonuclei identified along the length of an isolated muscle fiber. Because a muscle fiber is not a single cell, its parts are often given special names such as: • Sarcolemma for plasma membrane • Sarcoplasmic reticulum for endoplasmic reticulum • Sarcosome for mitochondrion • Sarcoplasm for cytoplasm Unit 7 3. Identify the structural components of a sarcomere. (pp. 179–182) Skeletal Muscle Contractile Unit * Motor Neuron * Sarcoplasmic reticulum * Action Potential * Myofibrils * Transverse or T-Tube * Z-Line * Sarcomere Unit 7 3. Identify the structural components of a sarcomere. (pp. 179–182) * Z-Line Skeletal Muscle Contractile Unit * Sarcomere * Actin * Myosin A single myofibril from a muscle fiber. Unit 7 3. Identify the structural components of a sarcomere. (pp. 179–182) Skeletal Muscle Contractile Unit * Sarcomere * Actin * Myosin * Z-Line * A Band ~ Thick * I Band ~ Thin Unit 7 3. Identify the structural components of a sarcomere. (pp. 179–182) Skeletal Muscle Contractile Unit Terms I-bands (isotropic) contain only thin myofilaments. iso- means equal , tropic- means turning A-bands (anisotropic) contain both thin and thick myofilaments. an- means without Z-line (German for Zwischenscheiben, meaning “between disks”) M-line (German for Mitte, meaning “middle”) Unit 7 3. Identify the structural components of a sarcomere. (pp. 179–182) Changes in Skeletal Muscle Contractile Unit Band/Line Contracted Muscle Stretched Muscle A-band ? No Change ? No Change I-band ? Shortens Z-line Moves?closer together ? Lengthens Moves?further apart Unit 7 4. Explain the key steps involved in the contraction of a skeletal muscle fiber. (pp. 182–184) Muscle Contraction Animation Contraction of skeletal muscle Muscle Contraction Movie Cross Bridging Cycle Muscle Contraction Animation Overview 4. Explain the key steps involved in the contraction of a skeletal muscle fiber. (pp. 182–184) Tension ? ? Resistance ? ? Unit 7 Contraction Unit 7 4. Explain the key steps involved in the contraction of a skeletal muscle fiber. (pp. 182–184) Quick Facts… • Every skeletal muscle fiber is under the direct control by a neuron at a neural muscular junction. • When an action potential arrives at a neural muscular junction and is transferred across the sarcolemma, the contraction process begins. • When an action potential reaches a muscle fiber it will cause Ca+2 ions to seep out of the sarcoplasmic reticulum into the myofibrils starting contraction. Unit 7 4. Explain the key steps involved in the contraction of a skeletal muscle fiber. (pp. 182–184) Neural Control of Muscle Contraction Synaptic Vesicle ACHe ACH Receptor Sites Sarcolemma of Motor end plate Synaptic Terminal Membrane Unit 7 4. Explain the key steps involved in the contraction of a skeletal muscle fiber. (pp. 182–184) Step 1: Release of Acetylcholine (ACh) Synaptic Vesicle ACh Unit 7 4. Explain the key steps involved in the contraction of a skeletal muscle fiber. (pp. 182–184) Step 2: Ach Binding at Motor End Plate Na+ Na+ Sarcolemma membrane becomes permeable to Na+ Na+ Na+ Na+ Na+ Unit 7 4. Explain the key steps involved in the contraction of a skeletal muscle fiber. (pp. 182–184) Step 3: Action Potential Conduction by Sarcolemma Action Potential Propagation AChE removing ACh in synaptic cleft Unit 7 4. Explain the key steps involved in the contraction of a skeletal muscle fiber. (pp. 182–184) Neuromuscular Junction Synapse Unit 7 4. Explain the key steps involved in the contraction of a skeletal muscle fiber. (pp. 182–184) Molecular Events of the Contraction Process Actin Active subunits Myosin Tropomyosine Troponin Fiber & Inside Myosin-Actin & fibera Head sacromere at Cross-bridge rest… site Attachment (in the absence +2) of Ca ADP P “Cocked” or Primed Myosin Head Unit 7 4. Explain the key steps involved in the contraction of a skeletal muscle fiber. (pp. 182–184) Step 1: Active-site exposure Ca+2 binds to Troponin ADP P Ca+2 Tropomyosine slides off the active site Ca+2 Active Myosin-Actin P Cross-bridge Attachment site Ca+2 released from the Sacroplasmic Reticulum is uncovered arrives at the sacromere. ADP Unit 7 4. Explain the key steps involved in the contraction of a skeletal muscle fiber. (pp. 182–184) Step 2: Cross-bridge Attachment ADP Ca+2 P ADP P Ca+2 Attachment of myosin head to exposed active site on the thin filament of the actin fiber Unit 7 4. Explain the key steps involved in the contraction of a skeletal muscle fiber. (pp. 182–184) Step 3: Pivoting of myosin head ADP P Ca+2 Ca+2 ADP P The myosine Myosin heads head pivot releases ADP action thrusts and P the actin fiber resulting in a to the leftof “pivoting” contracting the head the sacromere toward the by a small center of the amount sacromere Unit 7 4. Explain the key steps involved in the contraction of a skeletal muscle fiber. (pp. 182–184) Step 4: Cross-bridge deattachment ATP Ca+2 Ca+2 ATP Myosin heads deattachs from the active site on the actin fiber when it binds with another ATP ATP can be supplied by aerobic or anaerobic cellular respiration or via CPATP cycle (page 190) Unit 7 4. Explain the key steps involved in the contraction of a skeletal muscle fiber. (pp. 182–184) Step 5: Myosin reactivation Myosin heads ADP Become P “cocked” or Ca reactivated again as they Ca split ATP into ADP and P ADP P and capture the bond The entire attachment –reattachment energy contraction that is cycle begins again until Ca+2 or ATP is removed. released +2 +2 Unit 7 4. Explain the key steps involved in the contraction of a skeletal muscle fiber. (pp. 182–184) Review: Sliding Filament Cross-Bridge Theory Unit 7 5. Compare the different types of muscle contractions. (pp. 187–189) Frequency of Muscle Fiber Stimulation Number of Muscle Fibers Involved Flavors of Contraction: Isotonic & Isometric Anti-Contraction : Muscle Elongation Unit 7 5. Compare the different types of muscle contractions. (pp. 187–189) Quick Facts… • Muscles are composed of 1,000’s of fibers. • Individual muscle fibers either 100% contracted or are 100% at rest known as the “all-or-nothing” principle” • A “twitch” along a single muscle fiber is a complete contraction cycle… at rest contraction at rest • The “recruited” more motor units into a contraction cycle, increases “tension”. • Repeated stimulation before relaxation results in more “twitches”;summation. Unit 7 5. Compare the different types of muscle contractions. (pp. 187–189) Twitch: Development of Tension Ca+2 levels dropbegins and cross-bridging declines. Action Cross-bridging Potential Sweeps between Across myosin the Sarcolemma. and actin. Resting Phase Maximum tension development Latent Period Contraction Phase Stimulus Relaxation Phase Unit 7 5. Compare the different types of muscle contractions. (pp. 187–189) Frequency of Muscle Fiber Stimulation Tension Stimulation Summation of twitches increases a muscle … POWER OUTPUT! Time Unit 7 5. Compare the different types of muscle contractions. (pp. 187–189) Frequency of Muscle Fiber Stimulation Tension Maximum Tension A muscle producing maximum tension through repeated summation is said to reach a state called …. Incomplete tetanus Time Unit 7 5. Compare the different types of muscle contractions. (pp. 187–189) Frequency of Muscle Fiber Stimulation Tension SR can’t reclaim Ca+2 fast enough for relaxation. Maximum Tension A muscle producing maximum tension through repeated summation while not allowing relaxation is said to reach a state called …. Complete tetanus Time Unit 7 5. Compare the different types of muscle contractions. (pp. 187–189) Number of Muscle Fibers Involved Skeletal Muscle Fascicle Threshold / Motor Unit Low / Blue Medium / Green Strong / Yellow Highest / Red Muscle Fibers / Cells Motor Unit Unit 7 5. Compare the different types of muscle contractions. (pp. 187–189) Quick Facts… • Muscles at rest maintain a “relaxed” tension created by various contracting motor units; this tension, called muscle tone helps maintain our posture. • If a muscle fiber is not stimulated on a regular basis is will atrophy, or become smaller and weaker. • Severe atrophy results in muscle fiber death. Dead fibers are not replaced. Unit 7 5. Compare the different types of muscle contractions. (pp. 187–189) Quick Facts… • Muscle contractions come in two flavors: Iso- equal, tonic- tension • Isotonic contraction … a contraction that results in the shortening of the entire muscle as it maintains a constant tension before relaxing. Iso- equal, metric- length • Isometric contraction … caused by a increase of tension that does not result in the shortening of the muscle or the moving a joint or any other oject. Unit 7 5. Compare the different types of muscle contractions. (pp. 187–189) Anti-Contraction : Muscle Elongation • Muscle only actively contract ! • Muscles passively relax or elongate or… • Gravity can cause the mass of the contracted, shorten muscle to “drop” or elongate during its relaxation cycle… • The “memory” of elastic connective tissue surround muscle fibers “uncoil” after a contraction… • The contraction of an “opposing” muscle stretches out its relaxed antagonist. Unit 7 6. Describe the mechanisms by which muscles obtain and use energy to power contractions. (pp. 189–192) Unit 7 6. Describe the mechanisms by which muscles obtain and use energy to power contractions. (pp. 189–192) Quick Facts… • Muscle contractions require large amounts of energy (~6 x1014 ATP/sec/muscle fiber) • Most of this energy is generated “on-demand”. • ATP is an energy-transfer molecule not an energy storage molecule. • Resting muscles (RM) transfer the energy stored in ATP to Creatine forming Creatine Phosphate (CP) and ADP. CP can then be used to convert ADP back into ATP “on demand”. • CP levels in RM’s are > ATP levels. Unit 7 6. Describe the mechanisms by which muscles obtain and use energy to power contractions. (pp. 189–192) Quick Facts… • Aerobic cellular respiration in mitochondria is used to recycle ADP + P + energy ATP during rest through moderate levels of activity. • When muscular activity uses up the available supplies of oxygen and or ATP and CP, available energy stored in the fiber’s glycogen deposits are converted through glycolysis to form ATP anaerobically. Unit 7 6. Describe the mechanisms by which muscles obtain and use energy to power contractions. (pp. 189–192) ATP ~ Adenosine TriPhosphate Life’s “Rechargeable Battery” Adenine 3 Phosphate Groups Ribose Unit 7 6. Describe the mechanisms by which muscles obtain and use energy to power contractions. (pp. 189–192) ATP ~ Adenosine TriPhosphate Unstable Life’s……………………“Rechargeable Battery” “Trapping Energy” “Releasing Energy” Unit 7 6. Describe the mechanisms by which muscles obtain and use energy to power contractions. (pp. 189–192) ATP ~ Adenosine TriPhosphate Because large amounts of ATP unstable… in resting muscle cells are …excess ATP transfers its third high energy ~P to a polypeptide called creatine forming creatine phosphate or CP. ATP + Creatine ADP + Creatine Creatine Phosphate Phosphokinase Unit 7 6. Describe the mechanisms by which muscles obtain and use energy to power contractions. (pp. 189–192) ATP ~ Adenosine TriPhosphate Energy from Cellular Respiration ATP When Cellular ATP is Low PO4 Creatine Energy for Muscle Contraction When Cellular ATP is High Creatine PO4 Phosphate ADP ATP Cycle ADP + CP ATP Unit 7 6. Describe the mechanisms by which muscles obtain and use energy to power contractions. (pp. 189–192) ATP ~ Adenosine TriPhosphate C-C bond energy in organic molecules can be released and trapped in molecules of ATP using the Krebs/ citric acid / tricarboxilic acid cycle; a slower but more efficient aerobic process. Or… Energy could be released and trapped in molecules of ATP using glycolysis; a quick but less efficient anaerobic process These processes prefer C-C bonds found in… 1st Carbohydrates > 2nd Lipids > 3rd Proteins Unit 7 6. Describe the mechanisms by which muscles obtain and use energy to power contractions. (pp. 189–192) Quick Facts… • Muscle fatigue can be caused by a prolonged oxygen debt, a by-product of glycolysis, called lactic acid, a decrease in the pH of the muscle fiber, or just a lack of ATP. • A period of muscle recovery follows muscle fatigue, in which pre-fatigue conditions or pre-exertion level are re-established. • Muscle recovery requires muscular, cardiovascular and hepatic systems to work together in order to reach homeostatic levels after heavy muscular exertion. Unit 7 7. Relate types of muscle fibers to muscular performance. (pp.193–195) 8. Distinguish between aerobic and anaerobic endurance and explain their implications for muscular performance. (p.192) Unit 7 8. Distinguish between aerobic and anaerobic endurance and explain their implications for muscular performance. (p. 192) First some vocabulary… Aerobic ~ Any process that requires oxygen is said to be an aerobic process. Like rusting, fire, or cellular respiration… Anaerobic ~ Any process that does not require oxygen is said to be an anaerobic process. Like fermentation or glycolysis… Unit 7 8. Distinguish between aerobic and anaerobic endurance and explain their implications for muscular performance. (p. 192) Some more vocabulary… Endurance ~ The ability to continue a given task. The amount of time an individual can perform a task. Power ~ The amount of work or energy expended in a given amount of time. The maximum amount of tension a muscle group can produce. Unit 7 7. Relate types of muscle fibers to muscular performance. (pp. 193– 195) Type I vs. Type II Fibers Two different types of muscle fiber can be found in most skeletal muscles. Dark vs. White vs. Pink “flesh” “Chicken vs.“Chicken vs. “Human Thigh” Breast” muscle” The Type I and Type II fibers differ in their… • Structure, • Biochemistry and • Performance Unit 7 7. Relate types of muscle fibers to muscular performance. (pp. 193– 195) Type I vs. Type II Fibers Type I (slow) Type II a (fast) Type II b Unit 7 7. Relate types of muscle fibers to muscular performance. (pp. 193– 195) Type I, Red, or Aerobic Muscle Fibers … • Also known as "slow-twitch" fibers, take 3x longer to contract after stimulation, • Activated by small-diameter, thus slowconducting, motor neurons, • Muscles containing many slow-twitch fibers have Egreater vascular support. • ERich in myoglobin and hence red in color, • Depend on cellular respiration for ATP production, contain Emany mitochondria, • EResistant to fatigue, and are dominant in muscles that are responsible for posture. Unit 7 7. Relate types of muscle fibers to muscular performance. (pp. 193– 195) Type II, White, or Anaerobic Muscle Fibers… • PAlso known as "fast-twitch" fibers, • PTwice the diameter (more sacromeres) and are more common then Type I fibers, • Activated by large-diameter, thus fastMost skeletal muscles contain some conducting, motor neurons, mixture of Type I and Type II fibers, but a • single Low in motor myoglobin rich contains in glycogen unit and always one hence are whitish color,never both. fiber type or the in other, • Depend on glycolysis for ATP production, therefore they contain few mitochondria, • Fatigue easily, dominant in muscles used for rapid and fine motor movements. Unit 7 8. Distinguish between aerobic and anaerobic endurance and explain their implications for muscular performance. (p. 192) Now we can consider how… Muscular Performance… A measure of how a muscle or muscle group responds to perform a task of any intensity. depends upon… • The “muscle fiber” makeup of the muscle and… • The physical conditioning of the person! Unit 7 8. Distinguish between aerobic and anaerobic endurance and explain their implications for muscular performance. (p. 192) Fast Fiber Conditioning Improves a muscle or muscle groups ability to sustain a short -term high tension effort by… “Bulking-Up” or Increasing the number of myofibrils in fast-twitch fibers (increasing its diameter) Increasing the standing supplies of glycogen/glucose (remembering that these fibers use glycolysis, an anaerobic reaction) Unit 7 8. Distinguish between aerobic and anaerobic endurance and explain their implications for muscular performance. (p. 192) Slow Fiber Conditioning Improves a muscle or muscle groups ability to sustain a long-term low tension effort by… “CardioVascular Training”… increasing the bodies ability to supply oxygen to the muscles by increasing lung capacity, RBC count & RBC hemoglobin content. (blood doping) “Carbo-Loading”… preparing for and improving the bodies ability to elevate the blood glucose levels on demand (remember, these fibers use aerobic respiration). Unit 7 9. Contrast skeletal, cardiac, and smooth muscles in terms of structure and function. (pp. 194–195) Unit 7 9. Contrast skeletal, cardiac, and smooth muscles in terms of structure and function. (pp. 194–195) Skeletal •Moves bones •Voluntary, capable of great work, but tires easily Smooth •Found around organs, such as the intestines and stomach •Involuntary, capable of sustained work for very long periods of time Cardiac: heart beat, capable of sustained work, mainly involuntary! Unit 7 9. Contrast skeletal, cardiac, and smooth muscles in terms of structure and function. (pp. 194–195) Muscle : Types Smooth Cardiac Skeletal Unit 7 9. Contrast skeletal, cardiac, and smooth muscles in terms of structure and function. (pp. 194–195) Muscle Type: Location Attached to bone Heart Walls of hollow organs blood vessles and glands Unit 7 9. Contrast skeletal, cardiac, and smooth muscles in terms of structure and function. (pp. 194–195) Muscle Type: Cell Shape Long, cylindrical Branched Spindleshaped Unit 7 9. Contrast skeletal, cardiac, and smooth muscles in terms of structure and function. (pp. 194–195) Muscle Type: Nucleus Multiple, peripheral Usually single, central Single, central Unit 7 9. Contrast skeletal, cardiac, and smooth muscles in terms of structure and function. (pp. 194–195) Muscle Type: Special Features Intercalated disks Cell-to-cell attachments Unit 7 9. Contrast skeletal, cardiac, and smooth muscles in terms of structure and function. (pp. 194–195) Muscle Type: Striations Yes Yes No Unit 7 9. Contrast skeletal, cardiac, and smooth muscles in terms of structure and function. (pp. 194–195) Muscle Type: Autorythmic No Yes, smooth sustained, & rythmic No Unit 7 9. Contrast skeletal, cardiac, and smooth muscles in terms of structure and function. (pp. 194–195) Muscle Type: Control Voluntary Involuntary Involuntary Unit 7 9. Contrast skeletal, cardiac, and smooth muscles in terms of structure and function. (pp. 194–195) Muscle Type: Function Move the whole body Heart contraction to propel blood through the body Compression of organs, ducts, glands, etc. Unit 7 9. Contrast skeletal, cardiac, and smooth muscles in terms of structure and function. (pp. 194–195) Cardiac muscle fibers are… • Smaller (than skeletal) •Have a single nucleus • Less extensive T-tubule system • Myofilaments/fibrils organized as sarcomeres Unit 7 9. Contrast skeletal, cardiac, and smooth muscles in terms of structure and function. (pp. 194–195) Cardiac muscle fibers… • Have extensive cell-to-cell Autonomic nervous system: connections at gap junctions that: the part (the of the nervous system • Add strength intercalated disks) thatdirect supplies stimulation to the • Permits transmission of electrical muscles, likejunctions) the signalsinvoluntary from cell-to-cell (the gap smooth andintrinsic cardiacconduction muscles, system • Provides its own to the considered so thatand it does notglands, rely upon a neural action “visceral organs”. potential to initiate contraction. • Rate and force of contraction is controlled by the autonomic nervous system however. Unit 7 9. Contrast skeletal, cardiac, and smooth muscles in terms of structure and function. (pp. 194–195) Smooth muscle fibers … • Are smaller than skeletal and cardiac, • Occur in bundles/sheets of short fibers, • Contraction are stimulated and controlled by the autonomic nervous system. • Do not end in tendons since they don’t attach or pull on bones! • Do not have troponin attached two the actin fibers • Have an extensive network of gap junctions between adjacent cells. Unit 7 9. Contrast skeletal, cardiac, and smooth muscles in terms of structure and function. (pp. 194–195) Smooth muscle fibers … • Rather than organized arrays of thick and thin filaments, actin-based thin filaments and myosin-based thick filaments are dispersed throughout the cytoplasm in a seemingly random manner. • The thin filaments are attached to the plasma membrane and to cytoskeletal elements. • The thick filaments are distributed through the cytoplasm (like the plastic webbing in a bag used to package fruit and vegetables) Unit 7 10. Identify the principal axial muscles of the body together with their origins and insertions. (pp. 199–204) Unit 7 10. Identify the principal axial muscles of the body together with their origins and insertions. (pp. 199–204) Origins & Insertions • Pretend you were a puppet • Imagine strings attached to your body at the origins and insertions of skeletal muscles. • Pick a muscle and touch these locations and in you imagination “string” that part of your puppet” (you) • What would happen if you pulled the string from the “origin’s” end? Unit 7 10. Identify the principal axial muscles of the body together with their origins and insertions. (pp. 199–204) Origins & Insertions HINT: The largest part of the muscles mass is closer to the origin of the muscle Unit 7 10. Identify the principal axial muscles of the body together with their origins and insertions. (pp. 199–204) *Sternocleidomastoid *Trapezius *Deltoid *Teres minor *Teres major *Infraspinatus *Latissimus dorsi Posterior, Dorsal View Unit 7 10. Identify the principal axial muscles of the body together with their origins and insertions. (pp. 199–204) *Orbicularis oris *Sternocleidomastoid *Deltoid *Masseter Anterior, Ventral View *Pectoralis major *Trapezius *Serratus anterior *External oblique *Rectus abdominis Unit 7 11. Identify the principal appendicular muscles of the body, together with their origins and insertions. (pp. 204–216) Unit 7 11. Identify the principal appendicular muscles of the body, together with their origins and insertions. (pp. 204–216) *Rectus femoralis *Gracilis *Sartorius *Vastus medialis Anterior, Ventral View *Vastus lateralis *Gastronemius *Fibularis * Soleus Unit 7 11. Identify the principal appendicular muscles of the body, together with their origins and insertions. (pp. 204–216) *Gluteus medius *Gluteus maximus *Gracilis *Abductor magnus *Biceps femoris *Gastronemius *Sartorius Posterior, Dorsal View * Soleus Unit 7 11. Identify the principal appendicular muscles of the body, together with their origins and insertions. (pp. 204–216) * Tibialis anterior *Gastronemius * Soleus * Fibularis muscle(s) * Extensor digitorum Laterial View Unit 7 11. Identify the principal appendicular muscles of the body, together with their origins and insertions. (pp. 204–216) *Brachioradius *Flexor carpi ulnaris Anterior View *Biceps brachii Unit 7 11. Identify the principal appendicular muscles of the body, together with their origins and insertions. (pp. 204–216) *Brachioradius *Triceps brachii *Extensor carpi ulnaris *Extensor carpi radialus *Extensor digitorum *Flexor carpi ulnaris Posterior View Unit 7 12. Describe the effects of exercise and aging on muscle tissue. (p. 216) Unit 7 12. Describe the effects of exercise and aging on muscle tissue. (p. 216) Unit 7