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Contents
Chapter 1:
General introduction
Chapter 2:
Molecular screening to colorectal cancer
9
29
Chapter 3:
DNA methylation of phosphatase and actin
regulator 3 detects colorectal cancer in stool and
complements FIT
61
Chapter 4:
Analytical sensitivity and stability of DNA methylation
testing in stool samples for colorectal cancer
detection 89
Chapter 5:
Stool proteomics reveals novel candidate
biomarkers for colorectal cancer screening
103
Chapter 6:
Promoter CpG island hypermethylation of Decoy
Receptor 1 (DCR1) is associated with poor response
to irinotecan in metastatic colorectal cancer
137
Chapter 7:
Promoter CpG island hypermethylation- and
H3K9me3 and H3K27me3-mediated epigenetic
silencing targets the deleted in colon cancer (DCC)
gene in colorectal carcinogenesis without affecting
neighboring genes on chromosomal region 18q21
161
Chapter 8:
DNA methylation and gene expression at
chromosomal loci with copy number gain in
colorectal cancer
181
Chapter 9:
Summary and general discussion
213
Chapter 10:
Nederlandse samenvatting
225
Curriculum Vitae
233
237
Dankwoord