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Genetics Notes Genetics Notes • Just a little review before we get into the new stuff… • The 6 characteristics all organisms share: – Have at least one cell – Can grow & develop – Have genetic material – Can reproduce – Have a metabolism – Can adapt & evolve Two types of genetic material • DNA (deoxyribonucleic acid) – – – – Holds the information for making all the traits in an organism Found in the nucleus, mitochondria, and chloroplasts Double stranded molecule Has 4 nucleotide bases • • • • A (adenine) T (thymine) C (cytosine) G (guanine) • RNA (ribonucleic acid) – – – – Carries the information from the DNA to the ribosomes Found in the ribosomes and traveling between nucleus and ribosomes Single stranded molecule Has 4 nucleotide bases • • • • A (adenine) U (uracil) C (cytosine) G (guanine) Nucleotide Bases • A nucleotide base is a molecule that makes up DNA and RNA – Kind of like the letters of the alphabet make up our words • Organisms from all 6 kingdoms have the same nucleotide bases in their RNA and DNA – All DNA and RNA (no matter what organism it comes from) is all built and works the exact same way – This is why we are able to take DNA from one organism and put it into other organisms and make it work • The only thing that makes DNA different in different organisms is the order of the nucleotide bases • The nucleotide bases from one strand of DNA always pair with a certain nucleotide base on the other strand (see next slide) – They also always pair with a certain nucleotide base on the RNA • This is how a DNA strand creates an RNA strand to send the information for making a trait out to the ribosomes Base pairing rules • DNA to DNA rules – A pairs with T – T pairs with A – G pairs with C – C pairs with G DNA Strand 1 ATAC GATC GATC GAC C CT DNA Strand 2 • DNA to RNA rules – A pairs with U – T pairs with A – G pairs with C – C pairs with G DNA Strand RNA Strand ATAC GATC GATC GAC C CT Codons • Once the DNA strand has created the RNA strand, the ribosomes will read the RNA strand 3 nucleotide bases at a time – A codon is a sequence of 3 nucleotide bases DNA Strand GTC AAT TCC GTG GCC ACT RNA Strand • Each codon stands for a specific amino acid – Amino acids are the building blocks of proteins – Ribosomes read the RNA one codon at a time and hook together the amino acids to make proteins Codon Rules • The first nucleotide base in the RNA codon is in the innermost circle • The second nucleotide base in the RNA codon is in the second ring outward • The third (last) nucleotide base in the RNA codon is in the third ring outward • The amino acid made by that RNA codon is in the outermost ring DNA Strand RNA Strand Amino Acids CAG TGC AA G CTT AGC CCA Proteins • A protein is a chain of amino acids • Proteins are used for creating many traits like: – – – – Speeding up metabolism reactions Building body parts, like muscles Coloring the skin, hair and eyes Causing the release of other chemicals • Proteins will begin with the amino acid MET and end with STOP DNA Strand CGG GTA TAC AAA AT G GAC CTG ACT TTT RNA Strand GCC CAU AUG UUU UAC CUG GAC UGA AAA Amino Acids • The DNA sequence that creates the RNA that creates the protein is called a gene – Genes begin with a codon that codes for MET and end with a STOP codon – In between genes are sequences called introns that do not create proteins or traits Types of Genes • Dominant genes are sequences of DNA that code for a working version of a protein – Examples of human traits caused by dominant genes: • Tongue rolling • Cleft chin • Achondroplasia (type of dwarfism) • Recessive genes are sequences of DNA that code for a non-working version of a protein – Examples of human traits caused by recessive genes: • Non-tongue rolling • Smooth chin • Normal height • For each trait there may be many different versions an organism could have – The different versions of the genes that cause different versions of a trait to appear are called alleles Special Cases • The number of different versions that exist for a trait can tell you a little about the number of genes that create it – In general, the more versions of a trait there are, the more genes are responsible for creating it (less versions mean fewer genes) • In many cases, there is 1 dominant gene and 1 recessive gene – This is true for a lot of traits that only have 2 versions • In some cases there is more than 1 dominant version of a gene – Blood type is an example of this • In some cases there is no real dominant version of a gene – Curly, wavy, and straight hair is an example of this • In some cases the protein made by 1 gene combines with the proteins made by other genes to change what they do – Height is an example of this • In some cases the protein made by 1 gene controls many different traits – Eye color, skin color, and hair color are examples of this Mutations • Mutations are changes in the sequence of the DNA or RNA bases • Mutations can happen at random as the DNA or RNA is copied or they can be caused by mutagens – Mutagens are substances that can cause mutations • Examples of mutagens: – Radiation from X-rays, sunlight, and radioactive materials – Some food additives – Some industrial chemicals • Some mutations cause new proteins to be made, which could lead to new traits (possibly good, possibly bad) Original Sequence Mutated Sequence DNA TAC AGT CAT ATT TAC AGT CAT ATT RNA AUG UCA GGC GUA UAA AUG UCA GGC GUA UAA Amino Acids Met Ser Stop Met Ser Stop CCG Gly Val CTG Asp Val • Some mutations cause proteins not to be made, which could be good or bad depending on what the protein did Original Sequence Mutated Sequence DNA TAC AGT CAT ATT TAC CAT ATT RNA AUG UCA GGC GUA UAA AUG UGA GGC GUA UAA Amino Acids Met Ser Stop Met Stop CCG Gly Val ACT Stop CCG Gly Val • Some mutations cause no changes in the protein at all Original Sequence Mutated Sequence DNA TAC AGT CAT ATT TAC AGT CAA ATT RNA AUG UCA GGC GUA UAA AUG UCA GGC GUU UAA Amino Acids Met Ser Stop Met Ser Stop CCG Gly Val CCG Gly Val • Putting it all together: • All traits are part genetic and part environmental – Some are more genetic – Some are more environmental – Some are well balanced • The environment can alter the traits at any of the levels above
