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Transcript 
Dubravka Šipuš, 2nd year
2013/2014
Mentor: A. Žmegač Horvat

Hemostasis – prevention of blood loss

Mechanisms:
1)
Vascular constriction
2)
Formation of a platelet plug
3)
Formation of a blood clot
4)
Growth of fibrous tissue

Fast process

Procoagulants and anticoagulants

Complex cascade of chemical reactions

Blood coagulation factors

Formation of prothrombin activator

Extrinsic pathway

Intrinsic pathway

Endothelial surface factors (smoothness,
glycocalyx, thrombomodulin)

Antithrombin III - heparin cofactor

Coumarin (warfarin)

Citrate ion, oxalate

Vitamin K deficiency

Diseases of the liver

Hemophilia

Thrombocytopenia


Hemophilia A - abnormality or deficiency of
Factor VIII
Recessive sex-linked, X chromosome
disorder

Guyton, Hall: Textbook of Medical Physiology
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