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Components of Blood
• Whole blood
– RBCs
– WBCs
– Platelets: cell fragments that aid in clotting
• Plasma
– 90% water (allows materials to dissolve)
– Amino acids, glucose, hormones, vitamins, salts, waste
– Concentrations allows diffusion in/out of blood stream
Platelets
• Job: Help form clots
to stop bleeding
• Proteins form a web
to trap cells &
platelets
White Blood
Cells
• Remove foreign
invaders & dead
cells
• Able to move
through body
tissue
Red Blood Cells
•
•
•
•
•
Produced from stem cells in bone marrow
Lose nucleus as they mature
Transport O2 to cells; remove CO2
O2 binds to hemoglobin proteins
Dead cells filtered by liver & spleen
Sickle Cell
Normal
ABO Blood Groups
• Antigens:
– Proteins on RBC’s
that determine
your blood type
– Help to identify
cells as foreign or
natural
– Analogy: Antigens
are like jersey’s
• Antibodies:
– Part of your
immune system
– Float freely in
plasma
– Job: attack
foreign antigens
Group A blood
Your Bwould
What
antibodies
happen
will
if a
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B this
antigens entered your blood?
virus.
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• A antigens on the surface of your RBCs
• B antibodies in your plasma
– only attack invaders with B antigens
Group B blood
What would happen if you gave this person
Their
antibodies would attack the
type AAblood?
donated blood. This person would die.
Vein
• B antigens on the surface of your RBCs
• A antibodies in your blood plasma
– only attack invaders with A antigens
Group AB blood
Nothing
Nothing
bad
bad
would
would
happen.
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What
What
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you
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have
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no
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this
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person
type
type
BAblood?
blood?to
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blood.
Vein
• Both A & B antigens on the surface of RBCs
• Neither A or B antibodies in your blood plasma
Group O blood
What
would
happen
if you
gave
this
The A
antibodies
will
attack.
This
person
blood?
persontype
willAdie.
Vein
• Neither A or B antigens on the surface of your RBCs
• Both A & B antibodies in your plasma
– will attack invaders with A or B antigens
Group O blood
What
happen
you gave
The
B would
antibodies
will ifattack.
This
this person
type B blood?
person
will die.
Vein
• Neither A or B antigens on the surface of your RBCs
• Both A & B antibodies in your plasma
– will attack invaders with A or B antigens
Group O blood
The
and B happen
antibodies
willgave
WhatAwould
if you
attack.
This type
person
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this person
ABwill
blood?
Vein
• Neither A or B antigens on the surface of your RBCs
• Both A & B antibodies in your plasma
– will attack invaders with A or B antigens
If you have type A blood, can you receive:
Type A blood?
Yes
Type B blood?
No
Type AB blood?
No
Type O blood?
Yes
B antibodies will attack any blood with B antigens.
If you have type B blood,
can you receive:
Type B blood?
Yes
Type A blood?
No
Type AB blood?
No
Type O blood?
Yes
A antibodies will attack any blood with A antigens.
If you have type AB blood,
can you receive:
Type AB blood?
Yes
Type A blood?
Yes
Type B blood?
Yes
Type O blood?
Yes
They have neither A nor B antibodies.
If you have type O blood, can you receive:
Type O blood?
Yes
Type A blood?
No
Type B blood?
No
Type AB blood?
No
A antibodies will attack any blood with A antigens.
B antibodies will attack any blood with B antigens.
Rh Factors
• If Rh+
– Cells contain the Rh
antigen (jersey)
– Don’t contain Rh
antibody
– Can receive + or blood
• If Rh– Cells lack the Rh
antigen, but…
– Contains Rh antibody
– Only receive Rhblood
Practice
problem
Blood type B+
Which antigens does
this person have?
A
B
Rh
Which antibodies does
this person have?
A
B
Rh
Practice
problem
Blood type AB+
Which antigens does
this person have?
A
B
Rh
Which antibodies does
this person have?
A
B
Rh
Practice
problem
Blood type O+
Which antigens does
this person have?
A
B
Rh
Which antibodies does
this person have?
A
B
Rh
Practice
problem
Blood type AB-
Which antigens does
this person have?
A
B
Rh
Which antibodies does
this person have?
A
B
Rh
Practice
problem
Blood type O-
Which antigens does
this person have?
A
B
Rh
Which antibodies does
this person have?
A
B
Rh
Francis was just in a bad accident and lost a lot of blood.
He is blood type B+. Can you help save him?
Blood type B+
Antigens: Which does
he have?
A
B
Rh
Antibodies: Which does
he have?
A
B
Rh
Francis has B+ blood type because
of the B and Rh antigens. If he is
given B+ blood in a transfusion…
Will his antibodies attack this blood?
No.
Can he receive B+ blood?
Yes.
Vein
Key Point:
A antibodies only attack
A antigens
Francis has B+ blood type because
of the B and Rh antigens. If he is
given B- blood in a transfusion…
Will his antibodies attack this blood?
No.
Can he receive B- blood?
Yes.
Vein
Key Point:
A antibodies only attack
A antigens
Francis has B+ blood type because
of the B and Rh antigens. If he is
given A+ blood in a transfusion…
Will his antibodies attack this blood?
Yes.
Can he receive A+ blood?
No.
Agglutination:
clumping of the
blood
Vein
Key Point:
A antibodies only attack
A antigens
Francis has B+ blood type because
of the B and Rh antigens. If he is
given A- blood in a transfusion…
Will his antibodies attack this blood?
Yes.
Can he receive A- blood?
No.
Agglutination:
clumping of the
blood
Vein
Key Point:
A antibodies only attack
A antigens
Francis has B+ blood type because
of the B and Rh antigens. If he is
given AB+ blood in a transfusion…
Will his antibodies attack this blood?
Yes.
Can he receive AB+ blood?
No.
Agglutination:
clumping of the
blood
Vein
Key Point:
A antibodies only attack
A antigens
Francis has B+ blood type because
of the B and Rh antigens. If he is
given AB- blood in a transfusion…
Will his antibodies attack this blood?
Yes.
Can he receive AB- blood?
No.
Agglutination:
clumping of the
blood
Vein
Key Point:
A antibodies only attack
A antigens
Francis has B+ blood type because
of the B and Rh antigens. If he is
given O+ blood in a transfusion…
Will his antibodies attack this blood?
No.
Can he receive O+ blood?
Yes.
Vein
Key Point:
A antibodies only attack
A antigens
Francis has B+ blood type because
of the B and Rh antigens. If he is
given O- blood in a transfusion…
Will his antibodies attack this blood?
No.
Can he receive O- blood?
Yes.
Vein
Key Point:
A antibodies only attack
A antigens
Blood Type Internet Lesson
Sebastian was just involved in an accident at work and
lost a lot of blood. He is blood type A-. Can you help
save him?
Blood type AAntigens: Which does
he have?
A
B
Rh
Antibodies: Which does
he have?
A
B
Rh
Sebastian has A- blood type
because of the A antigen. If he is
given A- blood in a transfusion…
Will his antibodies attack this blood?
No.
Can he receive A- blood?
Yes.
Vein
Key Point:
B antibodies attack
B antigens
Rh antibodies
attack Rh antigens
Sebastian has A- blood type
because of the A antigen. If he is
given A+ blood in a transfusion…
Will his antibodies attack this blood?
Yes. But only the Rh antibodies will
attack.
Can he receive A+ blood?
No.
Vein
Key Point:
B antibodies attack
B antigens
Rh antibodies
attack Rh antigens
Sebastian has A- blood type
because of the A antigen. If he is
given B- blood in a transfusion…
Will his antibodies attack this blood?
Yes. But only the B antibodies will
attack.
Can he receive B- blood?
No.
Vein
Key Point:
B antibodies attack
B antigens
Rh antibodies
attack Rh antigens
Sebastian has A- blood type
because of the A antigen. If he is
given B+ blood in a transfusion…
Will his antibodies attack this blood?
Yes.
Can he receive B+ blood?
No.
Vein
Key Point:
B antibodies attack
B antigens
Rh antibodies
attack Rh antigens
Sebastian has A- blood type
because of the A antigen. If he is
given AB- blood in a transfusion…
Will his antibodies attack this blood?
Yes. But only the B antibodies
attack.
Can he receive AB- blood?
No.
Vein
Key Point:
B antibodies attack
B antigens
Rh antibodies
attack Rh antigens
Sebastian has A- blood type
because of the A antigen. If he is
given AB+ blood in a transfusion…
Will his antibodies attack this blood?
Yes.
Can he receive AB+ blood?
No.
Vein
Key Point:
B antibodies attack
B antigens
Rh antibodies
attack Rh antigens
Sebastian has A- blood type
because of the A antigen. If he is
given O+ blood in a transfusion…
Will his antibodies attack this blood?
Yes. But only the Rh antibodies will
attack.
Can he receive O+ blood?
No.
Vein
Key Point:
B antibodies attack
B antigens
Rh antibodies
attack Rh antigens
Sebastian has A- blood type
because of the A antigen. If he is
given O- blood in a transfusion…
Will his antibodies attack this blood?
No. His A antibodies only attack A
antigens.
Can he receive O- blood?
Yes.
Vein
Key Point:
B antibodies attack
B antigens
Rh antibodies
attack Rh antigens
Kobe Kuiz
1)
2)
3)
4)
5)
6)
What are the components found inside blood?
What are the ingredients of plasma?
What is the purpose/function of RBCs?
Which part of blood stop bleeding when cut?
What do antibodies bind with?
If a person has type AB-, which antigens do they possess?
Which antibodies?
7) If a person has type O+, which antigens do they possess?
Which antibodies?
8) If a person is type A-, list all the blood types this person can
receive in a transfusion.
9) If a person is type O-, list all the blood types this person can
receive in a transfusion.