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Dose-response relationships. A. The toxic response to a chemical is evaluated at several doses in the toxic or lethal range. The midpoint of the curve
representing percent of population responding (response here is death) versus dose (log scale) represents the LD50, or the concentration of drug that is
lethal in 50% of the population. B. A linear transformation of the data in panel A is provided by plotting the log of the dose administered versus the percent
of the population mortality, in probit units. For a discussion of probit units, see Chapter 4 in Goodman and Gilman’s The Pharmacological Basis of
Therapeutics, 12th Edition.
Source: Clinical and Environmental Toxicity, Workbook and Casebook for Goodman and Gilman's The Pharmacological Basis of Therapeutics
Citation: Rollins DE, Blumenthal DK. Workbook and Casebook for Goodman and Gilman's The Pharmacological Basis of Therapeutics; 2016
Available at: http://mhmedical.com/ Accessed: May 14, 2017
Copyright © 2017 McGraw-Hill Education. All rights reserved
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