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K, Patel F2013 Modified by DYH Clostridium perfringens • • • • • Gram positive Obligate anaerobe Rod shaped Forms endospores Genome contains 3,031,430 base pairs and 2,660 protein coding regions. • Causal agent in food poisoning and gas gangrene Clostridium perfringens bacteria that had been grown in Schaedler's broth (From CDC) Gas Gangrene (Myonecrotic Lesion) http://www.casesjournal.com/content/1/1/252 K, Patel F2013 Modified by DYH Clostridium perfringens Pathogenesis • Classified in into 5 groups • Gas Gangrene (A-E) based on (myonecrotic lesion): production of 4 major • C. perfringens enters host through wound toxins (alpha, beta, • Saccharolytic enzymes epsilon, iota toxins) break down sugars for • Hemolysins, enterotoxins, anaerobic glycolysis and hyaluronidases, and fermentation colonization factors also • Hyaluronidase acts as coded for spreading factor • Alpha and theta toxin • Beta2 toxin and collagen degrade host cells adhesion genes found on • Active degradation leads plasmid to myonecrotic leasions.
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