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DEVELOPMENT OF CONNECTIVE TISSUE
Mesenchyme
Loose Connective Tissue
Fibers
Fibroblasts
Mesenchymal
Cells
Cell Lineage from Mesenchymal Cells
TYPES OF CONNECTIVE TISSUE
Loose Connective
Tissue
(e.i. mesentery, omentum)
Dense Irregular
Connective Tissue
(e.i. dermis of skin)
Dense Regular
Connective Tissue
(e.i. tendons, ligaments,
cornea)
DENSE IRREGULAR CONNECTIVE TISSUE
(DERMIS OF SKIN)
DENSE REGULAR CONNECTIVE TISSUE
Tendon (longitudinal Section)
Tendon (tranverse Section)
ELASTIC CONNECTIVE TISSUE IN BLOOD VESSEL WALL
Internal
elastic
lamina
CONNECTIVE TISSUE FIBERS
Collagenous Fibers
(bundles)
Reticular Fibers
(networks)
Elastic Fibers
(anastomosing bundles)
RETICULAR CONNECTIVE TISSUE
reticular fibers
(argyrophilic)
COLLAGEN
Fiber
Fibril
Microfibril
FIBER
BUNDLE
Periodic Bands
Tropocollagen
alpha 1 peptide
alpha 2 peptide
TEM of Collagen Fibers
SEM of Collagen Fibers
SCANNING EM OF COLLAGEN FIBER BUNDLES
TEM of Fibroblast and Collagen Bundles
FIBROBLAST
collagen fiber
bundles
RER
procollagen
tropocollagen
ground
substance
(mucopolysaccharide)
Collagen Types
I - skin, bone, tendon cornea (most common type)
II- cartilage, embryonic cornea
III- reticular fibers, loose c.t., blood vessel walls, dermis
IV- basal lamina of epithelium
(no fibers, mat of randomly-oriented molecules)
TEM OF FIBROBLAST WITH COLLAGEN BUNDLES
FIXED CONNECTIVE TISSUE CELL TYPES
Fibroblast
(fiber producing cell)
Fibrocyte
(mesenchymal- pluropotent)
Adipocytes
(fat storage)
Fixed Macrophage
(histiocyte)
Fixed Connective Tissue Cells
Macrophage (light micrograph)
Adipocytes
fibroblast
TEM of Macrophage
MONONUCLEAR PHAGOCYTIC SYSTEM
(reticuloendothelial system)
Giant Cell
Monocyte
Mononuclear
wandering
cell
Macrophages
spleen
lymph nodes
bone marrow
coalescence
Osteoclasts
bone
resorption
Kupffer Cells
liver
sinusoids
Microglial
Cells
Sinusoidal
Endothelia
central
nervous
system
liver
spleen
marrow
connective tissue
lung
serous cavities
( all characterized by phagocytic activity)
LYMPHOCYTES AND PLASMA CELLS
(Agents of the immune response)
Lymphocytes
Plasma Cells
differentiation stimulated by
immune activation
(produce
immunoglobulins
-antibodies)
EOSINOPHILES
actively phagocytic
destroy immune complexes
(antigen-antibody)
MAST CELLS
Secretion Products:
1. Slow-reaction substance of anaphalaxis
2. Heparin- anticoagulant
3. Histamine- stimulates inflammation
4. Serotonin- vasoconstrictor
5. Eosinophil Chemotactic Factor
Connective Tissue Cells
Plasma Cell
Lymphocyte
Macrophage
TRANSMISSION EM OF AN EOSINOPHILE
TRANSMISSION EM OF A MAST CELL