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Developmental stage-specific biphasic roles of Wnt signaling
in cardiomyogenesis and hematopoiesis
(Atsuhiko T. Naito et al, 2006, Development)
Wnt signalings in embryonic development
Zygotically expressed wnt8 may be involved in specifying or
patterning ventral mesoderm.
(Gregory M Kelly, 1995, Development)
Members of the Wnt and Tgfβ/Bmp families play critical roles
in anterior-posterior patterning
(Yamaguchi TP, 2001, Curr Biol)
Interactions between Wnt and Vg1 signalling pathways initiate primitive
streak formation in the chick embryo
(Isaac skromne, 2001, Development)
Wnt signaling
AP Axis patterning, primitive streak formation,
mesoderm induction
Wnt signalings that related in development of mouse embryo
(Kimelman D, 2006, nature)
Development of Mouse embryo
(Yamaguchi TP, 2001, Curr Biol)
Many controversies about Wnt signaling in heart formation
In chick embryo, Wnt signals from the neural tube block ectopic
cardiogenesis
(Eldad Tzahor, 2001, Genes & Dev)
Dkk-1 can induce heart-specific gene expression in noncardiogenic
mesoderm of Xenopus laevis
(Valerie A., 2000, Genes & Dev)
Heart development in Drosophila requires the segment polarity
gene wingless(Wg).
(Wu X, 1995, Dev Biol)
Overexpression of Wg using heat shock promoter increases the
amount of heart formation in Drosophila
(Maiyon Park, 1996, Dev Biol)
Overexpression of Wnt-1, 3 causes on reduction of cardiomyocyte
In chick embryo
(Eldad Tzahor, 2001, Genes & Dev)
Overexpression of Wg causes on abundance of cardiomyocyte
In gastrula of Drosophila
(Park M, 1996, Dev Biol)
about a fourfold increase of heart precusor cell occurs in hswg embryos
upon heat-shock for 30min at 37.5℃
Hanging drop method
Wnt Signaling promotes Cardiomyogenesis During Early Stage of
ES Cell Differentiation.
Wnt Signaling promotes Cardiomyogenesis During Early Stage of
ES Cell Differentiation.
Wnt Signaling inhibits Cardiomyogenesis During Late Stage of
ES Cell Differentiation.
Wnt inhibits cardiomyocyte differentiation in the late phase by
suppressing BMP signaling.
Modulation of Wnt Signaling Enables Efficient Induction of
Cardiomyocytes from ES Cells.
Wnt signals exhibit developmental stage-specific, biphasic, and
antagonistic effects on cardiogenesis and hematopoiesis.
(Yamaguchi TP, 2001, Curr Biol)