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Chapter 4 Standard #1: Cell Division (Mitosis) - 7.S.1.1.2 Standard #2: Cell Reproduction (Meiosis) Standard #3: DNA - 7.S.1.1.2 7.S.1.1.2 Standard #4: Models/Charts/Graphs/Data - 7.S.1.2.3/7.S.1.6.2/7.S.1.6.3 Chromosome Sexual reproduction DNA Mitosis Asexual reproduction Meiosis RNA Genes Mutation Cell Cycle Interphase Prophase Anaphase Metaphase Telophase Diploid Haploid The birth, life and death of cells. Cells have a life cycle A cell life cycle is the birth, growth & development, death of a cell Cell cycle consists of two major periods: interphase and cell division Interphase: a growth phase (long) Interphase is divided into 3 phases: G1 phase = growth phase (DNA & protein made) S phase = DNA synthesis takes place (DNA replicates) G2 phase = growth phase (RNA & protein made, proofreading DNA) https://www.youtube.com/watch?v=lf9rcqifx34 cell cycle and mitosis Cell division: short phase Cell division is divided into 2 phases: 1. Mitosis = nucleus of cell divides 2. Cytokinesis = cytoplasm divides Cell division increases the number of cells in an organism Cell division allows growth and replaces worn out or damaged cells Single celled organisms reproduce through cell division http://www.youtube.com/watch?v=C6hn3sA0ip0 cycle and mitosis https://www.youtube.com/watch?v=JcZQkmooyPk min 1-4 animal cells cell cycle and mitosis http://www.youtube.com/watch?v=AhgRhXl7w_g mitosis only 1:30 min whole movie good cell CHROMATIDS / CHROMOSOMES / GENES: INTERPHASE: DNA duplicates (goes from 46 chromosomes to 92 chromatids) Growth phase Interphase is NOT a step of Mitosis. It happens before mitosis begins. Cells division that results in 2 identical daughter cells http://www.phschool.com/science/biology_place/labbench/lab3/mitfilm.html https://www.youtube.com/watch?v=gwcwSZIfKlM&list= PLb3m_5kPlQwOn78c2uHdyFbXn8RHPZAYK MITOSIS: cell divides 1 time Makes 2 identical copies replace or makes new cells Body cell go through mitosis Diploid cells= cells with complete set of chromosomes 46 46 92 46 cell divides 1 time Makes 2 identical copies replace or makes new cells Body cell go through mitosis Diploid cells= cells with complete set of chromosomes PROPHASE: Cell gets idea that it is time to divide DNA Condenses Centrioles move to opposite ends of cell Spindle fibers begin to form PROPHASE: Cell gets idea that it is time to divide DNA Condenses Centrioles move to opposite ends of cell Spindle fibers begin to form PROMETAPHASE: Nuclear membrane breaks down Spindle fibers attach to the chromosomes METAPHASE: (MIDDLE) DNA line up on center axis Centromere of each pair attaches to spindle fibers ANAPHASE: (AWAY) Separation begins Chromosomes splits and migrate to opposite sides Anaphase complete when chromatids get the side of the cell TELOPHASE: (TWO) 2 New nuclei form Spindle fibers start to disappear Chromosomes start to uncoil CYTOKINESIS: (CYTOPLASM) Not a step of mitosis. It IS a step in the cell cycle. Cytoplasm splits Result = Two identical daughter cells formed. Diploid cells = cells with complete sets of chromosomes. REPRODUCTION: Cell reproduction is process organism use to produce others of their own kind. ASEXUAL REPRODUCTION: Asexual reproduction: A way to make a new organism from one organism. In asexual reproduction the heredity information is identical to the parent organism. 2 TYPES OF ASEXUAL REPRODUCTION: Budding: a new organism develops from an outgrowth (bud) on parent ,due to cell division Regeneration: Example: Paramecium& hydra & strawberries Process that uses cell division to regrow body parts. Example: sponges Another type of asexual reproduction is fission http://www.youtube.com/watch?v=wfbhwq95Duc binary (bacteria, fungi, protest reproduce this way) http://www.youtube.com/watch?v=d5dOSyaKWTQ SEXUAL REPRODUCTION: A way to make a new organism from gametes (sperm and egg) joining together. Recombination of genes MEIOSIS: Type of cell division Produces 4 cells, with ½ the # of chromosomes as parent = Haploid cells Happens when it is time to reproduce an organism It shuffles the cell’s genes around Cell divides 2 times (meiosis 1 & meiosis 2) MEIOSIS DEFINITION: cell division that produces reproductive cells in sexually reproducing organisms. MEIOSIS I : Interphase I = DNA duplicated Prophase I = nuclear membrane goes away each duplicated chromosome comes near its similar duplicated mate Metaphase I = pairs of duplicated chromosomes line up in center of cell. Centromere of each chromatid pair becomes attached to one spindle fiber Anaphase I = 2 pairs of chromatids pulled to ends of cell Each duplicated chromosome still has 2 chromatids. Telophase I = cytoplasm divides and 2 new cells form Each new cell has 1 duplicated chromosome from each similar pair MEIOSIS II: 2 cells from Meiosis I now start meiosis II Prophase II = duplicated chromosomes & spindle fibers reappear in each new cell Metaphase II = duplicated chromosomes line up at center of the cell Centromere attaches to 2 spindle fibers instead of 1 Anaphase II = centromere divides , chromatids separate to opposite ends of cell Telophase II = spindle fibers disappear & nuclear membrane forms Cyctoplasm divides RESULT OF MEIOSIS: 4 sex cells with 23 unpaired (unduplicated) chromosomes each 1) DNA stands for Dioxyribonucleic acid. 2) DNA contains instructions that code for development, function and structure of an organism. 3) DNA carries genetic information that is passed form one generation to the next. http://www.youtube.com/watch?v=zwibgNGe4aY 5 min good. http://www.youtube.com/watch?v=qy8dk5iS1f0 1 min DNA STRUCTURE 1) DNA is a nucleic acid (organic compound) with subunits called nucleotides. 2) 3 Parts to nucleotides: Phosphate group Sugar (deoxyribose) Nitrogen base – 4 different nitrogen bases: Adenine (A) Thymine (T) Cytosine (C) Guanine (G) 3) DNA is a double helix structure (twisted ladder) Sides of ladder = alternate sugar phosphate group Rungs of ladder = pairs of nitrogen bases DNA REPLICATION: 1) In order for DNA to be passed from 1 generation to the next, it must be able to replicate an exact copy of itself. 2) DNA replicates before a cell divides. 3) Steps to DNA replication: a. DNA helix unwinds b. 2 strands unzips c. Each strand acts as a template for the new strands. d. Free nucleotides pair with bases along each of the DNA strands. 4) The result of DNA replication is 2 identical strands of DNA. http://www.youtube.com/watch?v=zdDkiRw1PdU 1 min GENES: 1) Genes are a section of DNA on a chromosome. 2) Genes determine the order of amino acids in proteins. 3) Change the order of amino acids and you make a different protein. 4) Proteins are made of chains of amino acids. https://www.youtube.com/watch?v=5MQdXjRPHmQ RIBONUCLEIC ACID: (RNA) 1) RNA stands for ribonucleic acid. 2) RNA’s most important job is to synthesize protein. 3) RNA structure is a long, single stranded chain of nucleotides. 4) 3 Types of RNA: a. mRNA: messenger RNA b. rRNA: ribosomal RNA c. tRNA: transfer RNA 5) RNA Structure: Sides of ladder = Ribose sugar & phosphate Rungs of ladder = 4 Nitrogen bases: Adenine, Guanine, Cytosine, Uracil PROTEIN SYNTHESIS (MAKING PROTEIN): 1) Protein synthesis is the process of decoding DNA to make a protein. 2) Proteins are large molecules composed of subunits called amino acids. 3) In a protein, different amino acids are linked together in a specific sequence. 4) The sequence of nucleotides (A,T,G,C) in DNA determine the sequence of amino acids. MUTATIONS 1) Mutations are any permeant change in the DNA sequence of a gene or chromosomes. Gene mutation or alterations in a genomic sequence can drastically impact a person's normal way of living. Such alterations can be either spontaneous or can be induced through radiation, viruses, mutagenic chemicals or transposons. Progeria Genetic Components: Alcoholism Color blindness Sickle cell Breast cancer Parkinson disease Autism