Download Tempany.U41_ppt

U41: Research resource for
Image guided therapy
PI: Ferenc Jolesz
©2005 Surgical Planning Laboratory, ARR
Slide 1
U41 Image guided therapy
• Background & Significance
– IGT technology growth
– Clinical imaging growth
• Aim
– Advance and propagate novel image
guided procedures
• To dev and implement IGT technologies
and allow rapid deployment in clinic
©2005 Surgical Planning Laboratory, ARR
Slide 2
U41 program outline
• Technology Research &
Development cores
• Admin core
• Biostatistics & Validation core
• Collaborations
– Internal (11)
– External (8)
©2005 Surgical Planning Laboratory, ARR
Slide 3
Program outline
• 5 TRD cores
– Computational
• Leader: Ron Kikinis
– Imaging
• Leader: Larry Panych
– MRI-guided therapy
• Leader: Clare Tempany
– Image guided Brain tumor surgery
• Leader: Alex Golby
– Focused Ultrasound
• Leader:Kullervo Hynynen
©2005 Surgical Planning Laboratory, ARR
Slide 4
Training & Dissemination
• Leaders: John Carrino & Nancy
Drinan
• Continuous activities on site
– First Monday seminars
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•
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R25 training grant
Visiting fellowships
Post docs, doctoral students
Graduate and undergraduate
students
©2005 Surgical Planning Laboratory, ARR
Slide 5
Collaborations
• Technology based
– Advancing imaging and image
processing into the OR of the future
• AMIGO
• Testing utility of IG
– Interventional Radiology
– Surgery
– Cancer therapy
– Cardiology (FUS ablation)
©2005 Surgical Planning Laboratory, ARR
Slide 6
U41 Collaborative projects
• Internal (11) NIH funded grants
– d2.1 G CT R01 AG 19513 MR guided
prostate diagnosis and brachytherapy
• External (8) NIH grants with BWH
collaborators
– d2.1p Christos Davatzikos 1R01 CA 104976
Targeted prostate biopsy using
mathematical optimization
©2005 Surgical Planning Laboratory, ARR
Slide 7
External collaborations
Major groups
• GE
– Doumoulin/Pelc
• 3 projects stem from the Engineering
research center for computed surgical
systems and technology (CISST ERC)of
Johns Hopkins
– Targeted biopsy (Christos Davatzikos)
– Transrectal prostate therapy robot in closed
MRI scanner (Gabor Fichtinger)
©2005 Surgical Planning Laboratory, ARR
Slide 8
MRI guided therapy core
• Neurosurgery
• Prostate program
• Interventional radiology
– Tumor ablation program (SGS0
– Spine interventions (JC)
©2005 Surgical Planning Laboratory, ARR
Slide 9
TRD core and collaborative interactions:
An example
• Prostate intervention
– Paradigm shift
• Improved image quality
– Higher field strength magnets
• Magnet design issues
– Closed bore systems
• MRT core
• Internal collaboration
• External collaboration
©2005 Surgical Planning Laboratory, ARR
Slide 10
Prostate Image guided
diagnosis & therapy
Detection Staging
Brachytherapy
FEM Based Deformation
Prostate biopsy
Mutual Information
Overlaid
Choline/Citrate
image
Treatment
monitoring
MR Robotics
SPL
Infrastructure
High Performance Computing
Gigabit network Terabyte storage
©2005 Surgical Planning Laboratory, ARR
Slide 11
Optimized biopsy project
Apex
7
5
1 Posterior
4
2
Anterior
right
Left
6
left
3 Right
Base
Probability of cancer occurrence shown in green (left) and its
adaptation (middle) to a stack of segmented intra-operative MR
images obtained at the BWH (right). Optimal biopsy sites are
transferred to the patient's space.
©2005 Surgical Planning Laboratory, ARR
* NIH R01 PI: Davatzikos et al
Slide 12
Validation methods
• Pre-clinical
– IGT technology-imaging system , guidance and
monitoring techniques-organ/disease specific
• IGT Procedural
– Image registration & segmentation
• DICE-Statistical analysis of registration matching
• Staple-analysis of expert and automated methods
– Procedure Feasibility
• Safe and effective
• Treatment specific -Cancer specific goals
– Patient safety, toxicity profiles, Cancer control-long
and short term outcomes
©2005 Surgical Planning Laboratory, ARR
Slide 13
3T endorectal coil MRI
©2005 Surgical Planning Laboratory, ARR
Slide 14
Bob Lenkinsky & Neil Rofsky BIDMC
Open vs Closed bore magnet design
©2005 Surgical Planning Laboratory, ARR
Slide 15
1.
Tempany CMC, McNeil BJ. Advances in biomedical imaging. JAMA 2000; 285(5):562-567.
©2005 Surgical Planning Laboratory, ARR
Slide 16