Download Curriculum Vitae

Curriculum Vitae
SECTION A: Personal details
Name: First Last, Degree(s)
Kyoungho Suk, Ph.D.
EDUCATION / TRAINING
(Begin with baccalaureate or other initial professional education and including postdoctoral training.)
University name/Institute
Degree
B.S.
M.S.
Ph.D.
Postdoc.
Kyungpook National University
Cornell University
University of California at Davis
Yale University
Year
1989
1991
1994
1996
Major
Genetic Engineering
Immunology
Immunology
Immunobiology
SECTION B: Positions and Honors
- Professional Career
2011.10 - present
2009.10 - present
2008.9 - 2009.9
2004.3 - 2011.9
2002.3 - 2004.2
1999.12 - 2002.2
1997.12 - 1999.11
Professor
Department of Pharmacology
Kyungpook National University School of Medicine
Daegu, Korea
Director
Brain Science and Engineering Institute
Kyungpook National University
Daegu, Korea
Visiting Associate Professor
Department of Biological Chemistry and Molecular Pharmacology
Harvard Medical School
Boston, Massachusetts, USA
Associate Professor
Department of Pharmacology
Kyungpook National University School of Medicine
Daegu, Korea
Assistant Professor
Department of Anatomy
Gyeongsang National University School of Medicine
Jinju, Korea
Research Professor
Graduate School of East-West Medical Science
Kyunghee University
Seoul, Korea
Postdoctoral fellow
Clinical Research Center
Samsung Biomedical Research Institute
Seoul, Korea
- Journal reviews and editorial board:
2013.12 - present
2014.01 - present
Associate editor
Journal of Neuroscience Research
Academic editor
Medicine
1
2014.11 - present
2013.11 - present
2012.1 - 2013.12
2013.11 - present
2009.12 - present
2007.1 - 2011.12
2013.11 - present
2012.1 - present
2012.1 - present
2000.1 - present
Editorial board
Biochemical Pharmacology
Editorial board
Journal of Neuroinflammation
Guest editor
Current Protein & Peptide Science
Editorial advisory board
Current Neuropharmacology
Regional editor (2009.12 - )
Member of editorial board (2006.1 – 2009.11)
Recent Patents in Inflammation & Allergy Drug Discovery
Handling editor
Molecules and Cells
Korean Society of Molecular and Cellular Biology
Editorial board
World Journal of Biological Chemistry
Editorial board
World Journal of Neurology
Editorial board
World Journal of Pharmacology
Ad hoc reviewer for the following journals
Journal of Biological Chemistry
Journal of Cell Science
Journal of Neurochemistry
Cell Death and Differentiation
Neuroscience
Journal of Neuroinflammation
Journal of Pharmacology and Experimental Therapeutics
Journal of Pharmacy and Pharmacology
Journal of Neuroscience Research
Brain Research
Brain Research Bulletin
Molecular Brain Research
British Journal of Pharmacology
Biochemical Pharmacology
European Journal of Biochemistry (FEBS Journal)
Neurotoxicology
Neuroscience Letters
Expert Review of Proteomics
- Academic Honors
1.
2.
3.
4.
2003.12; Excellent Researcher Awards from the Minister of Health and Welfare (Korea)
2010, 2011, 2012, 2013; “Best Professor” awards from KNU School of Medicine
2014. 10; Excellent Paper Awards from The Korean Association of Immunologists
2015. 5; Academic Achievement Awards from Kyungpook National Univ.
SECTION C: Publication List (past 5 years)
98. Hwang J, Lee S, Lee J, Kwon T, Kim D, Kim H, Park H, Suk K. Gangliosides induce autophagic cell death
in astrocytes. Brit. J. Pharmacol. 159: 586-603 (2010).
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99. Seo M, Lee W, Suk K. Identification of novel cell migration-promoting genes by a functional genetic
screen. FASEB J. 24(2):464-78 (2010).
100. Jeon ST, Kim WJ, Lee SM, Lee MY, Park SB, Lee SH, Kim IS, Suk K, Choi BK, Choi EM, Kwon BS,
Lee WH. Reverse signaling through BAFF differentially regulates the expression of inflammatory mediators and
cytoskeletal movements in THP-1 cells. Immunol Cell Biol. 88(2):148-56 (2010).
101. Ock J, Kim S, Yi K, Kim N, Han H, Cho J, Suk K. A novel anti-neuroinflammatory pyridylimidazole
compound KR-31360. Biochem Pharmacol. 79: 596-609 (2010).
102. Ock J, Han H, Hong S, Lee S, Han Y, Kwon B, Suk K. Obovatol attenuates microglia-mediated
neuroinflammation: implications of redox regulation. Brit. J. Pharmacol. 159(8):1646-62 (2010. 04).
103. Ock J, Suk K. Anti-inflammatory effects of synthetic compound KT-14480 in lipopolysaccharidestimulated microglia cells. J. Pharm. Pharmacol. 62(2):279-85 (2010. 02).
104. Ock J. Hong S, Suk K. Identification of KT-15073 as an inhibitor of lipopolysaccharide-induced
microglial activation. Biol. Pharm. Bull. 33(3): 461-467 (2010).
105. Hwang H, Lee S, Lee W, Lee H, Suk K. Stimulation of glucocorticoid-induced TNF receptor familyrelated protein ligand (GITRL) induces inflammatory activation of microglia in culture. J. Neurosci. Res.
88(10):2188-96 (2010. 08).
106. Endale M, Kim S, Lee W, Kim S, Suk K, Cho J, Park H, Wagley Y, Kim S, Oh J, Rhee M. Ischemia
induces regulator of G protein signaling protein upregulation and enhances apoptosis in astrocytes. Am. J.
Physiol. Cell Physiol. 298(3):C611-23 (2010).
107. Park S, Chun K, Kim J, Suk K, Jung Y, Lee W. The differential effect of high and low molecular weight
fucoidans on the severity of collagen-induced arthritis in mice. Phytotherapy Res. 24: 1384–1391 (2010).
108. Suk K. Combined analysis of glia secretome and CSF proteome: toward systematic understanding of
neuroinflammation and discovery of novel biomarkers. Expert Review of Proteomics. 7(2):263-74 (2010. 04).
Review
109. Hwang J, Hwang H, Lee H, Suk K. Microglia signaling as a target of donepezil. Neuropharmacology. 58:
1122-1129 (2010. 06).
110. Suk K. A novel functional gene selection method provides a systematic view of cell migration. Cell
Adhesion & Migration. 4(2): 207-210 (2010. 04). Review
111. Ko HM, Koppula S, Kim BW, Kim IS, Hwang BY, Suk K, Park EJ, Choi DK. Inflexin attenuates
proinflammatory responses and nuclear factor-kappaB activation in LPS-treated microglia. Eur J Pharmacol.
633(1-3):98-106.
112. Kim WJ, Lee MY, Kim JH, Suk K, Lee WH. Decursinol angelate blocks transmigration and inflammatory
activation of cancer cells through inhibition of PI3K, ERK and NF-kB activation. Cancer Letters. 296(1):35-42
(2010. 10).
113. Song MJ, Baek IJ, Seo MC, Kim SH, Suk K, Woodman OL, Williams SJ, Kim IK. Effects of 3’,4’dihydroxyflavonol on vascular contraction in rat aortic rings. Clin Exp Pharmacol Physiol. 37(8):803-10 (2010.
08).
114. Lee MG, Jun G, Choi HS, Jang HS, Bae YC, Suk K, Jang IS, Choi BJ. Operant conditioning of rat
navigation using electrical stimulation for directional cues and rewards. Behav Processes 84(3):715-20 (2010.
07).
115. Park SB, Kim SH, Suk K, Lee HS, Kwon TK, Ju MG, Jeon H, Kim DK, Lim JP, Shin TY. Clinopodium
gracile inhibits mast cell-mediated allergic inflammation: involvement of calcium and nuclear factor-kappaB.
Exp Biol Med (Maywood). 235(5):606-13 (2010. 05).
116. Lee SM, Jeon ST, Suk K, Lee WH. Macrophages express membrane bound form of APRIL that can
generate immunomodulatory signals. Immunology 131(3):350-6 (2010. 11).
117. Choi DK, Koppula S, Choi M, Suk K. Recent developments in the inhibitors of neuroinflammation and
neurodegeneration: inflammatory oxidative enzymes as a drug target. Expert Opin Ther Pat. 2010
Nov;20(11):1531-46. Review
118. Lee SH, Kim EJ, Suk K, Kim IS, Lee WH. TL1A induces the expression of TGF-β-inducible gene h3
(βig-h3) through PKC, PI3K, and ERK in THP-1 cells. Cell Immunol. 2010;266(1):61-6.
119. Kim JY, Kim H, Suk K, Lee WH. Activation of CD147 with cyclophilin a induces the expression of
IFITM1 through ERK and PI3K in THP-1 cells. Mediators Inflamm. 2010:821940. Epub 2010 Aug 16.
120. Jeon H, Lee S, Lee WH, Suk K. Analysis of glial secretome: The long pentraxin PTX3 modulates
phagocytic activity of microglia. J Neuroimmunol. 2010 Dec 15;229(1-2):63-72.
121. Jeon H, Go Y, Seo M, Lee WH, Suk K. Functional selection of phagocytosis-promoting genes: cell
sorting-based selection. J Biomol Screen. 2010 Sep;15(8):949-55.
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122. Hwang J, Lee HJ, Lee WH, Suk K. NF-κB as a common signaling pathway in ganglioside-induced
autophagic cell death and activation of astrocytes. J Neuroimmunol. 2010 Sep 14;226(1-2):66-72.
123. Lee SM, Kim EJ, Suk K, Lee WH. Stimulation of FasL Induces Production of Proinflammatory Mediators
Through Activation of Mitogen-Activated Protein Kinases and Nuclear Factor-κB in THP-1 Cells.
Inflammation. 2010 Dec 9. [Epub ahead of print]
124. Lee SM, Kim WJ, Suk K, Lee WH. Cell to Cell Interaction Can Activate Membrane-bound APRIL Which
Are Expressed on Inflammatory Macrophages. Immune Netw. 2010 Oct;10(5):173-80.
125. Ock J, Lee HA, Ismail IA, Lee HJ, Kwon BM, Suk K, Lee WH, Hong SH. Differential antiproliferation
effect of 2'-benzoyloxycinnamaldehyde in K-ras-transformed cells via downregulation of thiol antioxidants.
Cancer Sci. 2011 Jan;102(1):212-8.
126. Hwang H, Jeon H, Ock J, Hong SH, Han YM, Kwon BM, Lee WH, Lee MS, Suk K. 2.2'Hydroxycinnamaldehyde targets low-density lipoprotein receptor-related protein-1 to inhibit lipopolysaccharideinduced microglial activation. J Neuroimmunol. 2011 Jan;230(1-2):52-64.
127. Suk K, Choi J, Suzuki Y, Ozturk SB, Mellor JC, Wong KH, Mackay JL, Gregory RI, Roth FP.
Reconstitution of human RNA interference in budding yeast. Nucleic Acids Res. 2011 Apr 1;39(7):e43.
128. Suh WM, Park SB, Lee S, Kim HH, Suk K, Son JH, Kwon TK, Choi HG, Lee SH, Kim SH. Suppression
of mast-cell-mediated allergic inflammation by Lindera obtusiloba. Exp Biol Med (Maywood). 2011
Feb;236(2):240-6.
129. Kim JH, Zheng LT, Lee WH, Suk K. Pro-apoptotic role of integrin β3 in glioma cells. J Neurochem. 2011
May;117(3):494-503.
130. Choi DK, Koppula S, Suk K. Inhibitors of microglial neurotoxicity: focus on natural products. Molecules.
2011 Jan 25;16(2):1021-43. Review.
131. Kim JH, Lee JY, Suk K. Therapeutic hypothermia in brain injuries and related diseases. Recent Pat
Inflamm Allergy Drug Discov. 2011 May 1;5(2):155-64. Review
132. Choi J, Lee HW, Suk K. Increased plasma levels of lipocalin 2 in mild cognitive impairment. J Neurol Sci.
2011 Jun 15;305(1-2):28-33.
133. Lee SM, Kim EJ, Suk K, Lee WH. BAFF and APRIL induce inflammatory activation of THP-1 cells
through interaction with their conventional receptors and activation of MAPK and NF-κB. Inflamm Res. 2011
Sep;60(9):807-15.
134. Choi J, Lee HW, Suk K. Plasma level of chitinase 3-like 1 protein increases in patients with early
Alzheimer's disease. J Neurol. 2011 Dec;258(12):2181-5.
135. Lee SM, Kim EJ, Suk K, Lee WH. CD300F Blocks Both MyD88 and TRIF-Mediated TLR Signaling
through Activation of Src Homology Region 2 Domain-Containing Phosphatase 1. J Immunol. 2011 Jun
1;186(11):6296-303.
136. Lee M, Suk K, Kang Y, McGeer E, McGeer PL. Neurotoxic factors released by stimulated human
monocytes and THP-1 cells. Brain Res. 2011 Jul 11;1400:99-111.
137. Jeon H, Zheng LT, Lee S, Lee WH, Park N, Park JY, Heo WD, Lee MS, Suk K. Comparative analysis of
the role of small G proteins in cell migration and cell death: cytoprotective and promigratory effects of RalA.
Exp Cell Res. 2011 Aug 15;317(14):2007-18.
138. Choi JS, Park J, Suk K, Moon C, Park YK, Han HS. Mild Hypothermia Attenuates Intercellular Adhesion
Molecule-1 Induction via Activation of Extracellular Signal-Regulated Kinase-1/2 in a Focal Cerebral Ischemia
Model. Stroke Res Treat. 2011;2011:846716.
139. Lee SM, Kim EJ, Suk K, Lee WH. Stimulation of Fas (CD95) induces production of pro-inflammatory
mediators through ERK/JNK-dependent activation of NF-κB in THP-1 cells. Cell Immunol. 2011;271(1):15762.
140. Kim JK, Lee SM, Suk K, Lee WH. A novel pathway responsible for lipopolysaccharide-induced
translational regulation of TNF-α and IL-6 expression involves protein kinase C and fascin. J Immunol. 2011
Dec 15;187(12):6327-34.
141. Lee SM, Kim EJ, Suk K, Lee WH. Synthetic peptides containing ITIM-like sequences of IREM-1 inhibit
BAFF-mediated regulation of interleukin-8 expression and phagocytosis through SHP-1 and/or PI3K.
Immunology. 2011 Oct;134(2):224-33.
142. Lee HW, Choi J, Suk K. Increases of pentraxin 3 plasma levels in patients with Parkinson's disease. Mov
Disord. 2011 Nov;26(13):2364-70.
143. Lee M, Kang Y, Suk K, Schwab C, Yu S, McGeer PL. Acidic fibroblast growth factor (FGF) potentiates
glial-mediated neurotoxicity by activating FGFR2 IIIb protein. J Biol Chem. 2011 Dec 2;286(48):41230-45.
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144. Lee S, Kim JH, Kim JH, Seo JW, Han HS, Lee WH, Mori K, Nakao K, Barasch J, Suk K. Lipocalin-2 Is a
chemokine inducer in the central nervous system: role of chemokine ligand 10 (CXCL10) in lipocalin-2-induced
cell migration. J Biol Chem. 2011 Dec 23;286(51):43855-70.
145. Kim H, Lee S, Park HC, Lee WH, Lee MS, Suk K. Modulation of glial and neuronal migration by
lipocalin-2 in zebrafish. Immune Netw. 2011 Dec;11(6):342-7.
146. Chang CY, Song MJ, Jeon SB, Yoon HJ, Lee DK, Kim IH, Suk K, Choi DK, Park EJ. Dual functionality
of myeloperoxidase in rotenone-exposed brain-resident immune cells. Am J Pathol. 2011 Aug;179(2):964-79.
147. Kim JH, Lee HW, Hwang J, Kim J, Lee MJ, Han HS, Lee WH, Suk K. Microglia-inhibiting activity of
Parkinson's disease drug amantadine. Neurobiol Aging. 2012 Sep;33(9):2145-59.
148. Lee S, Lee WH, Lee MS, Mori K, Suk K. Regulation by lipocalin-2 of neuronal cell death, migration, and
morphology. J Neurosci Res. 2012 Mar;90(3):540-50.
149. Kim EJ, Lee SM, Suk K, Lee WH. CD300a and CD300f differentially regulate the MyD88 and TRIFmediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines.
Immunology. 2012 Mar;135(3):226-35.
150. Lee M, Kwon BM, Suk K, McGeer E, McGeer PL. Effects of Obovatol on GSH Depleted Glia-Mediated
Neurotoxicity and Oxidative Damage. J Neuroimmune Pharmacol. 2012 Mar;7(1):173-86.
151. Suk K. Delivering Alcohol Neurotoxicity into Nucleus, When Clusterin Meets Bcl(XL): A Commentary.
Alcohol Clin Exp Res. 2012 May;36(5):745-7. Commentary.
152. Suk K, Ock J. Chemical genetics of neuroinflammation: natural and synthetic compounds as microglial
inhibitors. Inflammopharmacology. 2012 Jun;20(3):151-8. Review
153. Lee S, Jang E, Kim JH, Kim JH, Lee WH, Suk K. Lipocalin-type prostaglandin D2 synthase regulates
glial cell migration and morphology through marcks: prostaglandin D2-independent effects. J Biol Chem. 2012
Mar 16;287(12):9414-28.
154. Jang HS, Jung JY, Jang IS, Jang KH, Kim SH, Ha JH, Suk K, Lee MG. L-theanine partially counteracts
caffeine-induced sleep disturbances in rats. Pharmacol Biochem Behav. 2012 Apr;101(2):217-21.
155. Kim JH, Nam YP, Jeon SM, Han HS, Suk K. Amyloid Neurotoxicity is Attenuated by Metallothionein:
Dual Mechanisms at Work. J Neurochem. 2012 Jun;121(5):751-62.
156. Jeon H, Kim JH, Kim JH, Lee WH, Lee MS, Suk K. Plasminogen activator inhibitor type 1 regulates
microglial motility and phagocytic activity. J Neuroinflammation. 2012 Jun 29;9(1):149.
157. Seo JW, Kim JH, Kim JH, Seo M, Han HS, Park J, Suk K. Time-dependent effects of hypothermia on
microglial activation and migration. J Neuroinflammation. 2012 Jul 9;9(1):164.
158. Kim JH, Cho YE, Seo M, Baek MC, Suk K. Glial proteome changes in response to moderate hypothermia.
Proteomics. Aug;12(15-16):2571-83.
159. Jha MK, Jeon S, Suk K. Glia as a Link between Neuroinflammation and Neuropathic Pain. Immune Netw.
2012 Apr;12(2):41-7. Review
160. Suk K. Unexpected role of lipocalin-type prostaglandin D synthase in brain: Regulation of glial cell
migration and morphology. Cell Adh Migr. 2012 May 1;6(3). Review
161. Cui Y, Wu J, Jung SC, Kim GO, Kyeong Ko R, Lee HJ, Yoo ES, Kang HK, Suk K, Eun SY.
Neuroprotective effect of methyl lucidone against microglia-mediated neurotoxicity. Eur J Pharmacol. 2012
Sep 5;690(1-3):4-12.
162. Lee SH, Lee JH, Kim EJ, Kim WJ, Suk K, Kim JH, Song GY, Lee WH. A novel derivative of decursin,
CSL-32, blocks migration and production of inflammatory mediators and modulates PI3K and NF-κB activities
in HT1080 cells. Cell Biol Int. 2012 Jul;36(7):683-8.
163. Nam Y, Choi M, Hwang H, Lee MG, Kwon BM, Lee WH, Suk K. Natural Flavone Jaceosidin is a
Neuroinflammation Inhibitor. Phytother Res. 2012 May 23. doi: 10.1002/ptr.4737. [Epub ahead of print]
164. Kim JK, Lee SM, Suk K, Lee WH. Synthetic peptides containing ITIM-like domains block expression of
inflammatory mediators and migration/invasion of cancer cells through activation of SHP-1 and PI3K. Cancer
Invest. 2012 Jun;30(5):364-71.
165. Han HS, Park J, Kim JH, Suk K. Molecular and cellular pathways as a target of therapeutic hypothermia:
pharmacological aspect. Curr Neuropharmacol. 2012 Mar;10(1):80-7. Review
166. Suk K. Proteomic analysis of glioma chemoresistance. Curr Neuropharmacol. 2012 Mar;10(1):72-9.
Review
167. Kim S, Kim KA, Suk K, Kim YH, Oh SH, Lee MK, Kim KW, Lee MS. Apoptosis of human islet cells by
cytokines. Immune Netw. 2012 Jun;12(3):113-7. Epub 2012 Jun 30.
168. Seo M, Kim JH, Cho YE, Baek MC, Suk K. Hypothermic regulation of astrocyte proteome profile in
experimental stroke. Electrophoresis. 2012 Dec;33(24):3835-48.
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169. Jha MK, Seo M, Kim JH, Kim BG, Cho JY, Suk K. The secretome signature of reactive glial cells and its
pathological implications. Biochim Biophys Acta. 2012 Dec 23. doi:pii: S1570-9639(12)00286-5. Review
170. Jha MK, Jeon S, Suk K. Pyruvate Dehydrogenase Kinases in the Nervous System: Their Principal
Functions in Neuronal-glial Metabolic Interaction and Neuro-metabolic Disorders. Curr Neuropharmacol. 2012
Dec;10(4):393-403. Review
171. Jang E, Lee S, Kim JH, Kim JH, Seo JW, Lee WH, Mori K, Nakao K, Suk K. Secreted protein lipocalin-2
promotes microglial M1 polarization. FASEB J. 2013 Mar;27(3):1176-90
172. Min BK, Suk K, Lee WH. Stimulation of CD107 affects LPS-induced cytokine secretion and cellular
adhesion through the ERK signaling pathway in the human macrophage-like cell line, THP-1. Cell Immunol.
2013 Feb;281(2):122-8.
173. Suk K. Glial proteins and peptides: implications in neuroinflammation. Curr Protein Pept Sci. 2013
Feb;14(1):2. Editorial.
174. Kim JH, Seo M, Han HS, Park J, Suk K. The neurovascular protection afforded by delayed local
hypothermia after transient middle cerebral artery occlusion. Curr Neurovasc Res. 2013 May 1;10(2):134-43.
175. Kim JH, Seo M, Suk K. Effects of therapeutic hypothermia on the glial proteome and phenotype. Curr
Protein Pept Sci. 2013 Feb;14(1):51-60. Review
176. Jha MK, Suk K. Glia-based biomarkers and their functional role in the CNS. Expert Rev Proteomics. 2013
Feb;10(1):43-63. Review.
177. Park YH, Lee YM, Kim DS, Park J, Suk K, Kim JK, Han HS. Hypothermia enhances induction of
protective protein metallothionein under ischemia. J Neuroinflammation. 2013 Feb 4;10:21.
178. Kim EJ, Suk K, Lee WH. SHPS-1 and a synthetic peptide representing its ITIM inhibit the MyD88, but
not TRIF, pathway of TLR signaling through activation of SHP and PI3K in THP-1 cells. Inflamm Res. 2013
Apr;62(4):377-86.
179. Jeon S, Jha MK, Ock J, Seo J, Jin M, Cho H, Lee WH, Suk K. Role of lipocalin-2-chemokine axis in the
development of neuropathic pain following peripheral nerve injury. J Biol Chem. 2013 Aug 16;288(33):2411627.
180. Jang E, Kim JH, Lee S, Kim JH, Seo JW, Jin M, Lee MG, Jang IS, Lee WH, Suk K. Phenotypic
polarization of activated astrocytes: the critical role of lipocalin-2 in the classical inflammatory activation of
astrocytes. J Immunol. 2013 Nov 15;191(10):5204-19.
181. Lim SG, Suk K, Lee WH. Reverse signaling from LIGHT promotes pro-inflammatory responses in the
human monocytic leukemia cell line, THP-1. Cell Immunol. 2013 Aug 11;285(1-2):10-17.
182. Nakamura M, Suk K, Lee MG, Jang IS. alpha(2A) adrenoceptor-mediated presynaptic inhibition of
GABAergic transmission in rat tuberomammillary nucleus neurons. J Neurochem. 2013 Jun;125(6):832-42.
183. Jha MK, Jeon S, Jin M, Lee WH, Suk K. Acute Phase Protein Lipocalin-2 Is Associated with Formalininduced Nociception and Pathological Pain. Immune Netw. 2013 Dec;13(6):289-94.
184. Jha MK, Suk K. Pyruvate Dehydrogenase Kinase as a Potential Therapeutic Target for Malignant
Gliomas. Brain Tumor Res Treat. 2013 Oct;1(2):57-63. Review.
185. Jha MK, Kim JH, Suk K. Proteome of brain glia: The molecular basis of diverse glial phenotypes.
Proteomics. 2014 Mar;14(4-5):378-98. Review.
186. Jha MK, Jeon S, Jin M, Ock J, Kim JH, Lee WH, Suk K. The pivotal role played by lipocalin-2 in chronic
inflammatory pain. Exp Neurol. 2014 Apr;254:41-53.
187. Jin M, Kim JH, Jang E, Lee YM, Soo Han H, Woo DK, Park DH, Kook H, Suk K. Lipocalin-2 deficiency
attenuates neuroinflammation and brain injury after transient middle cerebral artery occlusion in mice. J Cereb
Blood Flow Metab. 2014 Aug;34(8):1306-14.
188. Nam Y, Kim JH, Seo M, Kim JH, Jin M, Jeon S, Seo JW, Lee WH, Bing SJ, Jee Y, Lee WK, Park DH,
Kook H, Suk K. Lipocalin-2 deficiency ameliorates experimental autoimmune encephalomyelitis: the
pathogenic role of lipocalin-2 in the central nervous system and peripheral lymphoid tissues. J Biol Chem. 2014
Jun 13;289(24):16773-89.
189. Kang K, Ko PW, Jin M, Suk K*, Lee HW*. Idiopathic normal-pressure hydrocephalus, cerebrospinal
fluid biomarkers, and the cerebrospinal fluid tap test. J Clin Neurosci. 2014 Aug;21(8):1398-403. (*cocorresponding author)
190. Kim JH, Kim JH, Cho YE, Baek MC, Jung JY, Lee MG, Jang IS, Lee HW, Suk K. Chronic sleep
deprivation-induced proteome changes in astrocytes of the rat hypothalamus. J Proteome Res. 2014 Sep
5;13(9):4047-61.
191. Nam YS, Kim Y, Joung H, Kwon DH, Choe N, Min HK, Kim YS, Kim HS, Kim DK, Cho YK, Kim YH,
Nam KI, Choi HC, Park DH, Suk K, Lee IK, Ahn Y, Lee CH, Choi HS, Eom GH, Kook H. Small heterodimer
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partner blocks cardiac hypertrophy by interfering with GATA6 signaling. Circ Res. 2014 Aug 15;115(5):493503.
192. Jin M, Jang E, Suk K. Lipocalin-2 Acts as a Neuroinflammatogen in Lipopolysaccharide-injected Mice.
Exp Neurobiol. 2014 Jun;23(2):155-62.
193. Kim JH, Yun SH, Jang KH, Park J, Han HS, Rhee D, Suk K. Delayed and prolonged local brain
hypothermia combined with decompressive craniectomy: a novel therapeutic strategy that modulates glial
dynamics. Exp Neurobiol. 2014 Jun;23(2):115-23. Review.
194. Jha MK, Suk K. Management of glia-mediated neuroinflammation and related patents. Recent Pat
Inflamm Allergy Drug Discov. 2014;8(2):118-24.
195. Lee S, Nam Y, Koo JY, Lim D, Park J, Ock J, Kim J, Suk K*, Park SB*. A small molecule binding
HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation. Nat. Chem. Biol. 2014 Dec;10(12):105560. (*co-corresponding author)
196. Seo M, Lee S, Kim JH, Lee WH, Hu G, Elledge SJ, Suk K. RNAi-based functional selection identifies
multiple cell migration regulators dependent on PI3K/PTEN/AKT pathway. Nat. Commun. 2014 Oct 28;5:5217.
doi: 10.1038/ncomms6217.
197. Yang ES, Bae JY, Kim TH, Kim YS, Suk K, Bae YC. Involvement of endoplasmic reticulum stress
response in orofacial inflammatory pain. Exp Neurobiol. 2014 Dec;23(4):372-80.
198. Jha MK, Lee HW, Kim S, Suk K. Innate immune proteins as biomarkers for CNS injury: critical
evaluation (WO 2013119673 A1). Expert Opin Ther Pat. 2015 Feb;25(2):241-5.
199. Jha MK, Lee SR, Park DH, Kook H, Park KG, Lee IK, Suk K. Diverse Functional Roles of Lipocalin-2 in
the Central Nervous System. Neuroscience & Biobehavioral Reviews. 2015 Feb 12;49C:135-156.
200. Paik H, Chung AY, Park HC, Park RW, Suk K, Kim J, Kim H, Lee K, Butte AJ. Repurpose terbutaline
sulfate for amyotrophic lateral sclerosis using electronic medical records. Sci Rep. 2015 Mar 5;5:8580. doi:
10.1038/srep08580.
201. Do J, Choi Y, Kook H, Suk K, Lee I, Park D. Retinal Hypoxia Induces Vascular Endothelial Growth
Factor through Induction of Estrogen-related Receptor <gamma>. Biochem Biophys Res Commun. 2015 May
1;460(2):457-63.
202. Jang SW, Lim SG, Suk K, Lee WH. Activation of lymphotoxin-beta receptor enhances the LPS-induced
expression of IL-8 through NF-κB and IRF-1. Immunol Lett. 2015 Jun;165(2):63-9.
203. Kim JK, Jang SW, Suk K, Lee WH. Fascin Regulates TLR4/PKC-mediated Translational Activation
Through miR-155 and miR-125b, which Targets the 3' Untranslated Region of TNF-α mRNA. Immunol Invest.
2015;44(3):309-20.
204. Kim HJ, Yoon HJ, Yoon KA, Gwon MR, Jin Seong S, Suk K, Kim SY, Yoon YR. Lipocalin-2 inhibits
osteoclast formation by suppressing the proliferation and differentiation of osteoclast lineage cells. Exp Cell Res.
2015 Jun 10;334(2):301-9.
205. Lee SM, Suk K, Lee WH. Myristoylated alanine-rich C kinase substrate (MARCKS) regulates the
expression of proinflammatory cytokines in macrophages through activation of p38/JNK MAPK and NF-κB.
Cell Immunol. 2015 Apr 24. pii: S0008-8749(15)00090-8. doi: 10.1016/j.cellimm.2015.04.004. [Epub ahead of
print]
206. Cui Y, Park JY, Wu J, Lee JH, Yang YS, Kang MS, Jung SC, Park JM, Yoo ES, Kim SH, Ahn Jo S, Suk
K, Eun SY. Dieckol Attenuates Microglia-mediated Neuronal Cell Death via ERK, Akt and NADPH Oxidasemediated Pathways. Korean J Physiol Pharmacol. 2015 May;19(3):219-28. doi: 10.4196/kjpp.2015.19.3.219.
Epub 2015 Apr 30.
207. Lee S, Jha MK, Suk K. Lipocalin-2 in the Inflammatory Activation of Brain Astrocytes. Crit Rev
Immunol. 2015;35(1):77-84.
208. Chun BY, Kim JH, Nam Y, Huh MI, Han S, Suk K. Pathological Involvement of Astrocyte-Derived
Lipocalin-2 in the Demyelinating Optic Neuritis. Invest Ophthalmol Vis Sci. 2015 Jun 1;56(6):3691-8.
SECTION D: Specialty and Present Interest
Central nervous system (CNS) is composed of neurons and glia. Although non-neuronal glial cells have been
merely thought to be supporting cells in the past, recent evidence indicates that they play an important role in
every aspect of brain physiology and pathology. Especially, they are the main component of neuroinflammation
and are associated with many CNS disorders such as Alzheimer’s and Parkinson’s disease. Our lab is interested
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in finding new diagnostic and therapeutic methods based on glia using a variety of molecular & cell biology
techniques and animal models. Specific areas of investigation include:
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Comparative analysis of glial secretome and cerebrospinal fluid proteome of patients
Chemical biology approach to find small-molecule inhibitors of neuroinflammation
Mapping of disease gene interaction network using yeast systems biology
Large-scale functional screen to identify novel cell migration regulators
Functional characterization of lipocalin protein family in glia and neuroinflammation
Research keywords:
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Neuroinflammation and neurodegeneration
Functional genomics and proteomics based on large-scale experiments
Neuron-glia interaction via optogenetic control of glia
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