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Membrane-type matrix metalloproteinase-mediated angiogenesis in a fibrin-collagen matrix by Annemie Collen, Roeland Hanemaaijer, Florea Lupu, Paul H. A. Quax, Natascha van Lent, Jos Grimbergen, Erna Peters, Pieter Koolwijk, and Victor W. M. van Hinsbergh Blood Volume 101(5):1810-1817 March 1, 2003 ©2003 by American Society of Hematology Plasmin(ogen) dependency of capillarylike tubular structure formation in a fibrin matrix by hMVECs.hMVECs were cultured on top of a 3-dimensional fibrin matrix in M199 with 10% human serum and 10% newborn calf serum (NBCS) and were not stimulated (A) or sti... Annemie Collen et al. Blood 2003;101:1810-1817 ©2003 by American Society of Hematology Formation of capillarylike tubular structures in a purified fibrin matrix depends on plasmin activity and not MMP activity.hMVECs were cultured on top of a 3-dimensional matrix containing M199 supplemented with 10% human serum (HS) and 10% NBCS and stimulat... Annemie Collen et al. Blood 2003;101:1810-1817 ©2003 by American Society of Hematology Formation of capillarylike tubular structures in a fibrin-collagen matrix depends on plasmin and MMP activity.hMVECs were cultured on top of a 3-dimensional matrix fibrin matrix containing 10% collagen in M199 supplemented with 10% HS and 10% NBCS and stimu... Annemie Collen et al. Blood 2003;101:1810-1817 ©2003 by American Society of Hematology TIMP-3 impairs capillarylike tubular structure formation.hMVECs were infected with control virus Ad.PC10 (AdCtrl), a virus containing TIMP-1 (AdTIMP-1) or TIMP-3 (AdTIMP-3) as described and were cultured on top of a 3-dimensional matrix containing fibrin an... Annemie Collen et al. Blood 2003;101:1810-1817 ©2003 by American Society of Hematology MT1-MMP activity is inhibited by TIMP-3.(A) Direct assay of MT1-MMP activity. Annemie Collen et al. Blood 2003;101:1810-1817 ©2003 by American Society of Hematology Localization of MMPs in endothelial cells present in the capillarylike tubular structures in a fibrin-collagen matrix.hMVECs were cultured on top of a 3-dimensional fibrin matrix containing 10% collagen in M199 with 10% human serum and 10% NBCS and were sti... Annemie Collen et al. Blood 2003;101:1810-1817 ©2003 by American Society of Hematology Localization of MMPs in neovessels in a human recanalized mural thrombus.Immunohistochemistry was performed on paraffin sections of a mural thrombus, as described in “Material and methods.” Fibrin(ogen) present in the thrombus was stained with a polyclonal ... Annemie Collen et al. Blood 2003;101:1810-1817 ©2003 by American Society of Hematology
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