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Sodium Intake and Cardiovascular Health
by Martin O’Donnell, Andrew Mente, and Salim Yusuf
Circulation Research
Volume 116(6):1046-1057
March 13, 2015
Copyright © American Heart Association, Inc. All rights reserved.
A and B, Forest plot for change in blood pressure per 1 g/d increase in sodium excretion (Mente
et al8).
Martin O’Donnell et al. Circ Res. 2015;116:1046-1057
Copyright © American Heart Association, Inc. All rights reserved.
Association between sodium intake and blood pressure (BP) by potassium intake groups
(Population Urban Rural Epidemiology [PURE] Study).
Martin O’Donnell et al. Circ Res. 2015;116:1046-1057
Copyright © American Heart Association, Inc. All rights reserved.
A, Relationship of risk and nutrient intake, showing the location of the 3 principal dietary
reference intakes.59 B, Estimated 24-hour urinary excretion of sodium and composite of
cardiovascular (CV) death, stroke, myocardial infarction and hospitalization for congestive heart
failure (secondary prevention cohort; Ongoing Telmisartan Alone and in combination with
Ramipril Global End point Trial [ONTARGET]/Telmisartan Randomized AssesmeNt Study in ACE
iNtolerant subject with cardiovascular Disease [TRANSCEND]).42 X-axis is level of sodium
intake and Y-axis is hazard ratio for risk of composite outcome.
Martin O’Donnell et al. Circ Res. 2015;116:1046-1057
Copyright © American Heart Association, Inc. All rights reserved.
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