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Appendix B: Ratio Constancy Proof for F-Optimal Designs under the Uniform Prior 158 Ratio Constancy of F-Optimal Designs under the Uniform Prior The F-optimal ratio constancy proof is very much like the D-optimal case. When β 1 ~ U(c, d ) , the Bayes risk is 1 min ∫ R(δ , β )π (β )dβ = min 2 δ ∈' ( d − c)( x 1 − x 2 ) (e − cx 2 − e − dx 2 ) (e − cx 2 − e − dx2 ) . + n2 x2 n1 x1 (1) When β 1 ~ U(ac, ad ) , the Bayes risk is 1 min ∫ R(δ , β )π (β )dβ = min δ ∈' ( ad − ac)( x 1* − x 1* ) 2 ( ) ( * * e − cx1* − e − dx1* e − cx1 − e − dx1 + n 2 x 1* n 1 x 1* ) . (2) Let x 1 and x2 be the solution that minimizes expression (1) when β 1 ~ U(c, d ) . Let x 1* and x *2 be the solution that minimizes expression (2) when β 1 ~ U(ac, ad ) . Multiplying the right hand side of a2 (2) by 2 gives a 1 min ∫ R(δ , β )π (β )dβ = min δ ∈' (d − c)( ax 1* − ax *2 ) 2 By grouping (ax *i ) , it is obvious that x *i = ( ) ( * * e − cx*2 − e − dx*2 e − cx1 − e − dx1 + n 2 ax *2 n 1ax 1* ) . (3) xi and these designs are ratio constant both in the a selection of EC’s. The following steps verify that equality of ECs holds among F-optimal Bayesian designs based on the uniform prior. c+d xi 2 q i = e =e c+ d * a x 2 i c + d xi a 2 a = e c+d xi 2 = e = q *i (4) Note that while it is not shown here, it can be verified using calculus techniques that the allocation percentages remain the same for designs based on β 1 ~ U(c, d ) and β 1 ~ U(ac, ad ) . 159