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Neuron Motor Unit • Is one motor neuron and all muscle fibers its branches innervate. • Delicate control - a few muscle fibers per motor unit. Stimulates 6 to ___ fibers.Eye • Gross movement have over ______ muscle fibers per unit. • All fibers in a motor unit contract when stimulated with a threshold stimulus. NEUROMUSCULAR JUNCTION ____ -the junction between a motor neuron ending and a muscle fiber. Composed of a motor neuron, and muscle fiber. Has a motor end plate. Motor end plate is the junction between the muscle fiber and the axon terminals. Nerve Action • 1. Action potential moves down the axon • 2. Increase in _____causes acetylecholine to be released. • 3.Acetylecholine moves synaptic gap • 4.Acetylecholine reaches motor end plate • 5.Acetylecholine _______ with receptors Nerve Action • 6. Repolarized • 7. Acetylecholine to _______ • 8. Acetylecholine is broken down to A_____ and C______. • 9. Ready again to receive an impulse. Single Muscle Contraction • 3 phases Latent period Contraction period Relaxation period Followed by recovery(refractory period) ISOTONIC • Equal + tension • Force used to produce work and work is ______. • Object moves and muscle shortens Isometric • Muscle produces heat but _______work is done • Muscle does not shortens • Examples Standing Holding a door Oxygen Debt • A_____ of extra oxygen needed to metabolize the accumulated lactic acid and restore normal ______ levels. Fatigue • Lactic acid builds up and makes the muscle to feel _________. • Body needs oxygen to change lactic acid into carbon dioxide and water. Aerobic • With ________ • Pyruvic acid + oxygen = CO2 + H2O + _________. Anaerobic •Without oxygen •Pyruvic Acid is changed to lactic acid. Contraction speed • Classified: Fast-twitch (type II fiber) Slow-twitch (type I fibers) Fast-twitch • • • • • Relaxation cycle is about 30msc More mitochondrea than slow-twitch Pale in color - _______ muscle Fast quick movement Example Eye - Hand Sprinter Slow-twitch • • • • • Relaxation cycle is about 3000msc Fewer mitochondrea than fast-twitch _______ Muscle Prolonged, steady contractions Example Back muscle Long distance runners Smooth Muscle • Appear smooth • Involuntary muscles • Contract and relation periods are slower than skeletal muscle • Action is ____________ • Contraction may last ____ sec or longer • Examples - stomach, intestine, bladder, uterus during child birth. Smooth Muscle • Poorly organized sarcoplasmic reticulum • NO Z line or T tubules • Types Single unit - sphincters, pacemaker cells Multiunit - iris of eye, goose bumps Cardiac Muscle • Found only in the __________! • Huge #’s of mitochondrea • Well developed sarcoplasmic reticulum and T tubules • Intercalated disk • Refractory period is ______msc, almost as long as the contraction Cardiac Muscle • Never stops beating in a life time • ____________beats a day • At 70 years old your heat would have pumped 2.5 billion times. • If oxygen is deprived _____ sec, cardiac muscle cells may stop contracting, resulting in heart failure. When things Go WRONG! Muscle injuries • Skeletal muscle - satellite cells under the endomysium cause cell division. • Smooth muscle - causes the proliferation of cells. Pregnancy enlarging of uterus. • Cardiac muscle - childhood can regenerate but in adults is replaced by connective tissue.