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Assignment 18 9.4.4 Let WD denotes week day (M-F), WE denotes week end (Sa-Su. Assumptions: 1. All expected frequencies are 1 or greater 2. At most 20% of the expected frequencies are less than 5. 3. Simple Random Sample STEP 1: HO: The proportion of child births occurring during the week is 5/7 HA: The proportion of child births occurring during the week is not 5/7. STEP 2: Births Observed Proportion Expected o-e WD WE Total 716 216 932 5/7 2/7 50.2857 -50.2857 665.7143 266.2857 (o-e)^2 Chi-Square subtotal (o-e)^2/e 2528.6516 3.7984 2528.6516 9.4960 13.2944 STEP 3: All of the expected frequencies are greater than one and none of the expected frequencies are less than 5 STEP 4: 0.05 STEP 5: From the Table in Step 2 s 2 13.2944 STEP 6: The distribution has 2-1=1 degrees of freedom, from Table 9 the p-value <0.005 since 0.005 7.879 STEP 7: The p-value is less than the significance level since 0.05 so we do not reject the null hypothesis STEP 8: Since the p-value is less than 0.005, the null hypothesis is rejected. From this study, there is sufficient evidence to support that the proportion of births during the week is not 5/7. 9.4.5 Let WF denote white feathers, DF denote dark feathers, SC denote small comb, and LC denote large comb. Assumptions: 4. All expected frequencies are 1 or greater 5. At most 20% of the expected frequencies are less than 5. 6. Simple Random Sample STEP 1: HO: The distribution of the white feathers & small comb, white feathers & large comb, dark feathers & small comb, and dark feathers & large comb for the chick offspring are consistent with the Mendelian expected ratios of 9:3:3:1 HA: The distribution of the chick offspring is not consistent with the Mendelian expectations. STEP 2: Chicks WF & SC WF & LC DF & SC DF & LC Total Observed Proportion Expected o-e (o-e)^2 111 37 9/16 3/16 106.875 35.625 4.125 1.375 17.01563 1.890625 34 8 190 3/16 1/16 35.625 11.875 -1.625 -3.875 2.640625 15.01563 Chi-Square subtotal (o-e)^2/e 0.159211 0.05307 0.074123 1.264474 1.550877 STEP 3: All of the expected frequencies are greater than one and none of the expected frequencies are less than 5 STEP 4: 0.10 STEP 5: From the Table in Step 2 s 2 1.550877 STEP 6: The distribution has 4-1=3 degrees of freedom, from Table 9 the p-value >0.2 since 0.2 4.64 STEP 7: The p-value is greater than the significance level since 0.10 so we do not reject the null hypothesis STEP 8: Since the p-value is greater than 0.2, there do not reject the null hypothesis. From this study, there is not sufficient evidence to support that the chick offspring are not consistent with the Mendelian distribution for feather color and comb height. 9.4.8 Assumptions: 1. All expected frequencies are 1 or greater 2. At most 20% of the expected frequencies are less than 5. 3. Simple Random Sample STEP 1: HO: All of the rats in each triplet are equally likely to develop cancer so the drug will not cause the treated rat to develop cancer prior to the other two control rats in each triplet. HA: The treated rat in each triplet is more likely to develop cancer from the drug then the two control rats. STEP 2: Rats Observed Tumor 12 first in the treated rat Tumor 8 first in one of the two control rats Total 20 Proportion Expected o-e (o-e)^2 1/3 6.6667 5.3333 28.4441 Chi-Square subtotal (o-e)^2/e 4.2666 2/3 13.3333 -5.333 28.4441 2.1333 6.3999 STEP 3: All of the expected frequencies are greater than one and none of the expected frequencies are less than 5 STEP 4: 0.01 STEP 5: From the Table in Step 2 s 2 6.3999 STEP 6: The distribution has 2-1=1 degrees of freedom. From Table 9 0.02 5.41 and 0.01 6.635 so 1 1 0.010 p value 0.02 2 2 0.005 p value 0.01 STEP 7: The p-value is less than the significance level since 0.01 so we reject the null hypothesis STEP 8: Since the p-value is between 0.005 and 0.01, the null hypothesis is rejected. From this study, there is sufficient evidence to support that the rats that are treated with the drug are more likely to develop cancer then the rats that are not treated with the drug. Problem 9.4.10HO: The distribution of black, brown, and white Mongolian gerbil progeny are consistent with the Mendelian expected ratios of 1:2:1 HA: The distribution of black, brown, and white Mongolian gerbil progeny are not consistent with the Mendelian expected ratios of 1:2:1 Gerbil Black Brown Observed 40 59 Proportion Expected 1/4 35.25 2/4 70.5 White Total 42 141 1/4 35.25 s 2 3.81 . The df=2 and from Table 9, 0.2 3.22 and 0.1 4.61 . With a p-value between (0.1, 0.2), we do not reject HO there is not sufficient evidence to support that the gerbil progeny are not consistent with the Mendelian expected ratio. 9.4.12 HO: The inheritance pattern for each of the leaf types of the cowpea plants are Type I= II= 12 , Type 16 1 3 , and Type III= 16 16 HA: The inheritance pattern for each of the leaf types of the cowpea plants are not Type I= Type II= 12 , 16 1 3 , and Type III= 16 16 Cowpea plant Type I Type II Type III Total Observed 179 44 23 246 Expected 184.5 46.125 15.375 s 2 4.04 . The df=2 and from Table 9, 0.2 3.22 and 0.1 4.61 . With a p-value between (0.1, 0.2), we do not reject HO there is not sufficient evidence to support that the cowpea plant leaf types are not consistent with the probabilities stated. 10.2.7 Condition Seizure-free Not Seizure-free Total Valproate 6 (6.49) 14 (13.51) 20 Phenytoin 6 (5.51) 11 (11.49) 17 Total 12 25 37 Assumptions 1. All expected frequencies are 1 or greater 2. At most 20% of the expected frequencies are less than 5. 3. Simple random sample STEP 1: The null and alternative hypotheses are H O : The Pr(Seizur e - free | Valproate) Pr(Seizure - free | Phenytoin ) Patients were seizure-free whether they took valproate or phenytoin H A : The Pr(Seizur e - free | Valproate) Pr(Seizure - free | Phenytoin ) Patients had different numbers of seizures whether they took valproate or phenytoin STEP 2: The expected frequencies are 12 20 Seizure - free & Valproate 6.49 37 12 17 Seizure - free & Phenytoin 5.51 37 25 20 Not Seizure - free & Valproate 13.51 37 25 17 Not Seizure - free & Phenytoin 11.49 37 STEP 3: The assumptions are met. None of the expected frequencies are 1 or less and none of the expected frequencies are less than five. STEP 4: 0.10 STEP 5: s2 s2 s2 6 6.49 2 6 5.512 14 13.512 11 11.49 2 6.49 5.51 13.51 11.49 0.0401 0.0436 0.0178 0.0226 0.1241 STEP 6: 2 has df 1. The nearest value to the chi - square test statistic is 02.20 1.64 so the p-value>0.20 STEP 7 P-value Significance level p-value > 0.20 > 0.10 Do not reject Ho STEP 8 With a p-value > 0.20, the null hypothesis is not rejected. The proportion of patients that are seizure free given they have taken phenytoin or valproate are the same. 10.2.12 Let p denote the probability of having a cold. Let 1 denote that the person has five or fewer social relationships. Let 2 denote that the person has six or more types of social relationships. The null and alternative hypotheses are as follows: H O : The number of social relationsh ips does not affect the cold incidence so p1 p 2 H A : The number of social relationsh ips does affect the cold incidence so p1 p 2 Condition Cold No cold Total Five or fewer 57 (48.58) 66 (74.42) 123 Six or more 52 (60.42) 101 (92.58) 153 Total 109 167 276 s2 4.35 With the degrees of freedom being 1, from Table 9 we find that 02.05 3.84 and 02.02 5.41 . This means that the 0.02 < p-value < 0.05. Since the significance level is 0.05 . The p-value is less than the significance level so we reject the null hypothesis H O . In conclusion, the more types of social relationships that a person changes the probability of getting a cold. Reject Ho STEP 6: With a p value 0.001 , the null hypothesis is rejected. There is a linear relationship between fat-free mass and energy expenditure. b. This study was an observational study. The researchers simply measured both fat-free mass and energy expenditure of each subject. c. Since this is an observational study, a cause and effect relationship can not be stated. What can be stated is that from the observational study there is a statistically significant correlation between fat free mass and energy expenditure.