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Coronary Artery Disease and Acute Coronary Syndrome Chapter 34 Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Leading Causes of Death Copyright © 2014 by Mosby, an imprint of Elsevier Inc. 2 Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Coronary Artery Disease (CAD) • Atherosclerosis Begins as soft deposits of fat that harden with age Referred to as “hardening of arteries” Atheromas (fatty deposits) prefer coronary arteries Also known as ASHD, CVHD, IHD, CHD Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Coronary Artery Disease Etiology and Pathophysiology • Atherosclerosis is the major cause of CAD Characterized by lipid deposits within intima of artery Endothelial injury and inflammation play a major role in development Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Stages of Atherosclerosis Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Coronary Artery Disease Etiology and Pathophysiology • C-reactive protein (CRP) Nonspecific marker of inflammation Increased in many patients with CAD Chronic exposure to CRP associated with unstable plaques and oxidation of LDL cholesterol Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Coronary Artery Disease Etiology and Pathophysiology • Collateral circulation Arterial anastomoses (or connections) within the coronary circulation Increased with chronic ischemia May be inadequate with rapid-onset CAD Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Vessel Occlusion With Collateral Circulation Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Case Study iStockphoto/Thinkstock • M. P. is a 58-year-old white male who visits the local health clinic for a physical examination. • He tells the health care provider that he occasionally gets “indigestion” when he mows the lawn. • It goes away in 5-10 minutes after he stops and rests. Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Risk Factors for CAD • Nonmodifiable risk factors Age Gender Ethnicity Family history Genetic predisposition Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Risk Factors for CAD • Modifiable risk factors Elevated serum lipids • Cholesterol >200 mg/dL (5.2 mmol/L) • Triglycerides >150 mg/dL (3.7 mmol/L) • High-density lipoproteins (HDL) • Low-density lipoproteins (LDL) • Treatment according to guidelines based on 10-year risk score Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Risk Factors for CAD • Modifiable risk factors Hypertension • >140/90 mm Hg or >130/80 mm Hg if diabetes or CKD • Begin lifestyle changes for prehypertension • Treat stage 1 or 2 hypertension with drugs Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Risk Factors for CAD • Modifiable risk factors Tobacco use • Increased catecholamine release • ↑ LDL, ↓ HDL, ↑oxygen radicals • ↑ Carbon monoxide Second-hand smoke Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Risk Factors for CAD • Modifiable risk factors Physical inactivity Obesity Diabetes Metabolic syndrome Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Risk Factors for CAD • Modifiable risk factors Psychologic states Homocysteine level Substance abuse Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Audience Response Question Two risk factors for coronary artery disease that increase the workload of the heart and increase myocardial oxygen demand are a. b. c. d. Obesity and smokeless tobacco use. Hypertension and cigarette smoking. Elevated serum lipids and diabetes mellitus. Physical inactivity and elevated homocysteine levels. Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Audience Response Question Which patient is most at risk for developing coronary artery disease? a. A hypertensive patient who smokes cigarettes b. An overweight patient who uses smokeless tobacco c. A patient who has diabetes and uses methamphetamines d. A sedentary patient who has elevated homocysteine levels Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Collaborative and Nursing Management: CAD • Prevention and early treatment • Identification of people at high risk Health history, including family history Presence of cardiovascular symptoms Environmental patterns: diet, activity Psychosocial history Values and beliefs about health and illness Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Collaborative and Nursing Management: CAD • Manage high-risk persons by controlling modifiable risk factors • Encourage lifestyle changes Education Clarify personal values Set realistic goals Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Collaborative and Nursing Management: CAD • Physical fitness FITT formula: 30 minutes most days plus weight training 2 days a week Regular physical activity contributes to • Weight reduction • Reduction of >10% in systolic BP • In some men more than women, increase in HDL cholesterol Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Collaborative and Nursing Management: CAD • Nutritional therapy ↓ Saturated fats and cholesterol ↑ Complex carbohydrates and fiber ↓ Red meat, egg yolks, whole milk ↑Omega-3 fatty acids Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Audience Response Question The nurse determines that teaching about implementing dietary changes to decrease the risk of CAD has been effective when the patient says, a. “I should not eat any red meat such as beef, pork, or lamb.” b. “I should have some type of fish at least 3 times a week.” c. “Most of my fat intake should be from olive oil or the oils in nuts.” d. “If I reduce the fat in my diet to about 5% of my calories, I will be much healthier.” Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Collaborative and Nursing Management: CAD • Lipid-lowering drug therapy If diet and exercise ineffective Statins • Inhibit cholesterol synthesis, decrease LDL, increase HDL • Monitor for liver damage and myopathy Niacin • Lowers LDL and triglyceride by inhibiting synthesis • Increases HDL • Flushing, pruritus, GI side effects, orthostatic hypotension Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Collaborative and Nursing Management: CAD • Lipid-lowering drug therapy Fibric acid derivatives (Lopid) • Decrease triglycerides and increase HDL • GI side effects Bile acid sequestrants • Increase conversion of cholesterol to bile acids • GI side effects; bind with other drugs Ezetimibe (Zetia) • Decrease absorption of dietary and biliary cholesterol Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Collaborative and Nursing Management: CAD • Antiplatelet therapy ASA Clopidogrel (Plavix) Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Gerontologic Considerations CAD • Increased incidence and mortality associated with CAD in older adults • Strategies to reduce risk and treat CAD are effective • Treat hypertension, ↑lipids • Smoking cessation Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Gerontologic Considerations CAD • Necessary to modify guidelines for physical activity Longer warm-up Longer periods of low-level activity Longer rest periods Avoid extremes of temperature 30 minutes most days minimum • Most likely to change when hospitalized or symptomatic Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Case Study M.P.’s health history and physical examination reveals the following risk factors for CAD: Family history of CAD Smokes 1 pack of cigarettes a day Sedentary lifestyle High fat diet BP 152/94 BMI 30.2 kg/m2 Copyright © 2014 by Mosby, an imprint of Elsevier Inc. iStockphoto/Thinkstock Case Study iStockphoto/Thinkstock • Based on the presence of these risk factors and M.P.’s complaints of “indigestion” associated with activity, what type of angina is M.P. likely experiencing? Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Clinical Manifestations of CAD Angina • Progressive disease • O2 demand > O2 supply → myocardial ischemia • Angina = reversible ischemia • Occurs when arteries are blocked 75% or more • Hypoxic within 10 seconds of occlusion • Viable for 20 minutes Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Clinical Manifestations of CAD Angina • Lack of oxygen and glucose leads to anaerobic metabolism • Lactic acid irritates nerve fibers → pain in cardiac nerves • Referred pain from transmission to the upper thoracic posterior nerve roots Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Clinical Manifestations of CAD Angina Pain • Pressure/ache • Squeezing, heavy, choking, or suffocating sensation • Rarely sharp or stabbing • Indigestion or burning • Various locations Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Clinical Manifestations of CAD Chronic Stable Angina • Intermittent chest pain that occurs over a long period with the same pattern of onset, duration, and intensity of symptoms • 5 to 15 minute duration • ST segment depression and/or Twave inversion • Control with drugs Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Chronic Stable Angina Types of Angina • Silent ischemia Ischemia that occurs in the absence of any subjective symptoms Associated with diabetic neuropathy Confirmed by ECG changes Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Chronic Stable Angina Types of Angina • Nocturnal angina Occurs only at night but not necessarily during sleep • Angina decubitus Chest pain that occurs only while lying down Relieved by standing or sitting Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Chronic Stable Angina Types of Angina • Prinzmetal’s (variant) angina Occurs at rest usually in response to spasm of major coronary artery Seen in patients with a history of migraine headaches and Raynaud’s phenomenon Spasm may occur in the absence of CAD Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Chronic Stable Angina Types of Angina • Prinzmetal’s (variant) angina Occurs at rest due to spasm of a major coronary artery May occur with or without CAD Not precipitated by increased demand Chest pain with marked, transient STsegment elevation Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Chronic Stable Angina Types of Angina • Microvascular angina Chest pain occurs in the absence of significant coronary atherosclerosis or coronary spasm Myocardial ischemia associated with abnormalities of the coronary microcirculation • Coronary microvascular disease (MVD) affects small, distal coronary arteries Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Case Study iStockphoto/Thinkstock • While awaiting diagnostic testing for M.P., what drug would you expect the health care provider to prescribe for M.P. to use if he develops the “indigestion” pain the next time he mows the lawn? Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Chronic Stable Angina Collaborative Care • Goal: ↓ O2 demand and/or ↑ O2 supply • Short-acting nitrates Dilate peripheral and coronary blood vessels Give sublingually (tablet) or by spray If no relief in 5 minutes, call EMS; if some relief ,repeat every 5 minutes for maximum 3 doses Patient teaching Can use prophylactically Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Chronic Stable Angina Collaborative Care • Long-acting nitrates To reduce angina incidence Main side effects: headache, orthostatic hypotension Methods of administration • Oral • Nitroglycerin (NTG) ointment • Transdermal controlled-release NTG Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Chronic Stable Angina Collaborative Care • Angiotensin-converting enzyme inhibitors • β-adrenergic blockers • Calcium channel blockers • Sodium current inhibitor Ranolazine (Ranexa) Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Chronic Stable Angina Collaborative Care • Diagnostic studies Chest x-ray Laboratory studies 12-lead ECG Calcium-score screening heart scan Echocardiogram Exercise stress test Pharmacologic nuclear imaging Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Case Study iStockphoto/Thinkstock • M.P.’s chest x-ray and ECG results are all within normal limits. • His cholesterol and triglyceride levels are also elevated. Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Case Study iStockphoto/Thinkstock • He develops chest pain and STsegment depression during an exercise stress test. • What additional testing would you expect M.P. to undergo at this point? Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Chronic Stable Angina Nursing/Collaborative Management • Cardiac catheterization/coronary angiography Visualize blockages (diagnostic) Open blockages (interventional) • Percutaneous coronary intervention (PCI) • Balloon angioplasty • Stent Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Placement of a Coronary Artery Stent Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Pre-PCI and Post-PCI With Stent Placement Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Case Study • M.P. undergoes a cardiac catheterization. • A 90% occlusion of his right coronary artery (RCA) is discovered. • He has a balloon angioplasty and stent placement. Copyright © 2014 by Mosby, an imprint of Elsevier Inc. iStockphoto/Thinkstock Case Study iStockphoto/Thinkstock • Discharge teaching related to CAD and necessary lifestyle changes (diet and exercise) is provided. • He is scheduled for a follow-up with his health care provider. Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Case Study iStockphoto/Thinkstock • Six months later, MP arrives in the emergency department (ED) complaining of severe, immobilizing chest pain radiating down his left arm. • He admits to not following his health care provider’s advice related to diet and exercise. Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Case Study iStockphoto/Thinkstock • He states that he thought the stent opened up his arteries and cured his CAD. • The ED physician suspects ACS. Explain this diagnosis. Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Acute Coronary Syndrome Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Acute Coronary Syndrome Etiology and Pathophysiology Deterioration of once stable plague Rupture Platelet aggregation Thrombus • Result Partial occlusion of coronary artery: UA or NSTEMI Total occlusion of coronary artery: STEMI Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Clinical Manifestations of ACS Unstable Angina • New in onset • Occurs at rest • Worsening pattern • Increase in frequency • Unpredictable • Medical emergency • Symptoms in women may be more vague Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Clinical Manifestations of ACS Myocardial Infarction (MI) • Result of sustained ischemia (>20 minutes), causing irreversible myocardial cell death (necrosis) • 80%-90% secondary to thrombus • Ischemia starts in subendocardium • Necrosis of entire thickness of myocardium takes 4 to 6 hours • Loss of contractile function Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Myocardial Infarction From Occlusion Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Acute Myocardial Infarction Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Clinical Manifestations of ACS Myocardial Infarction • Pain Severe, immobilizing chest pain not relieved by rest, position change, or nitrate administration Heaviness, pressure, tightness, burning, constriction, crushing Substernal, retrosternal, epigastric More common in AM Atypical in women, elderly No pain if cardiac neuropathy (diabetes) Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Clinical Manifestations of ACS Myocardial Infarction • Pain Described as heaviness, constriction, tightness, burning, pressure, or crushing Common locations: substernal, retrosternal, or epigastric areas; pain may radiate to neck, jaw, arms Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Clinical Manifestations of ACS Myocardial Infarction • Catecholamine release – stimulation of SNS Release of glycogen Diaphoresis Vasoconstriction of peripheral blood vessels Skin: ashen, clammy, and/or cool to touch Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Clinical Manifestations of ACS Myocardial Infarction • Cardiovascular Initially, ↑ HR and BP, then ↓ BP (secondary to ↓ in CO) Crackles Jugular venous distention Abnormal heart sounds • S3 or S4 • New murmur Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Clinical Manifestations of ACS Myocardial Infarction • Nausea and vomiting Reflex stimulation of the vomiting center by severe pain Vasovagal reflex • Fever Up to 100.4° F (38° C) in first 24 hours Systemic inflammatory process caused by myocardial cell death Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Myocardial Infarction Healing Process • Within 24 hours, leukocytes infiltrate the area of cell death • Proteolytic enzymes of neutrophils and macrophages begin to remove necrotic tissue by fourth day → thin wall • Necrotic zone identifiable by ECG changes and nuclear scanning • Collagen matrix laid down Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Myocardial Infarction Healing Process • 10 to 14 days after MI, scar tissue is still weak • Myocardium vulnerable to stress • Monitor patient carefully as activity level increases Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Myocardial Infarction Healing Process • By 6 weeks after MI, scar tissue has replaced necrotic tissue Area is said to be healed, but less compliant • Ventricular remodeling Normal myocardium will hypertrophy and dilate in an attempt to compensate for the infarcted muscle Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Complications of Myocardial Infarction • Dysrhythmias Most common complication Present in 80% of MI patients Can be caused by ischemia, electrolyte imbalances, or SNS stimulation Life-threatening dysrhythmias seen most often with anterior MI, heart failure, or shock Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Complications of Myocardial Infarction • Heart failure Occurs when the pumping power of the heart has diminished Can be subtle or severe • Cardiogenic shock Occurs because of severe LV failure Requires aggressive management Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Complications of Myocardial Infarction • Papillary muscle dysfunction Causes mitral valve regurgitation Aggravates an already compromised LV → rapid clinical deterioration • Ventricular aneurysm Myocardial wall becomes thinned and bulges out during contraction Leads to HF, dysrhythmias, and angina Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Complications of Myocardial Infarction • Acute pericarditis An inflammation of visceral and/or parietal pericardium May result in cardiac tamponade, ↓ LV filling and emptying, heart failure Chest pain Pericardial friction rub ECG changes Treated with antiinflammatory agents Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Complications of Myocardial Infarction • Dressler syndrome Pericarditis with effusion and fever that develops 4 to 6 weeks after MI Pericardial (chest) pain Pericardial friction rub Pericardial effusion Arthralgia Treated with short-term corticosteroids Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Unstable Angina and MI Diagnostic Studies • Detailed health history • 12-lead ECG Changes in QRS complex, ST segment, and T wave Distinguish between STEMI and NSTEMI Pathologic Q wave Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Serum Cardiac Markers After MI Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Unstable Angina and MI Diagnostic Studies • Coronary angiography • Exercise or pharmacologic stress testing • Echocardiogram Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Case Study • Identify priority interventions for M.P. on his arrival at the ED. Copyright © 2014 by Mosby, an imprint of Elsevier Inc. iStockphoto/Thinkstock Collaborative Care Acute Coronary Syndrome • Initial interventions 12-lead ECG Semi-fowler’s position Oxygen IV access Nitroglycerin (SL) and ASA (chewable) Morphine Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Case Study iStockphoto/Thinkstock • M.P.’s ECG demonstrates significant ST elevation. • What evidence-based intervention would you expect to prepare M.P. to undergo within 90 minutes of arrival to the ED? Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Collaborative Care Acute Coronary Syndrome • Ongoing monitoring Treat dysrhythmias Frequent vital sign monitoring Bed rest/limited activity for 12–24 hours • UA or NSTEMI Aspirin, heparin, and glycoprotein inhibitor Coronary angiography with PCI once stable Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Collaborative Care Acute Coronary Syndrome • STEMI or NSTEMI with + cardiac markers → reperfusion therapy • Emergent PCI Treatment of choice for confirmed MI Goal: 90 minutes from door to catheter laboratory Balloon angioplasty + drug-eluting stent(s) Many advantages over CABG Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Collaborative Care Acute Coronary Syndrome • Thrombolytic therapy When PCI not available Stops infarction process by dissolving thrombus Within 6 hours of onset of symptoms Ideally within first hour Given IV Patient selection critical Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Collaborative Care Acute Coronary Syndrome • Thrombolytic therapy Draw blood and start 2–3 IV sites Complete invasive procedures prior Administer according to protocol Monitor closely for signs of bleeding Assess for signs of reperfusion • Return of ST segment to baseline best marker • IV heparin to prevent reocclusion Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Collaborative Care Acute Coronary Syndrome • Coronary surgical revascularization Failed medical management Presence of left main coronary artery or three-vessel disease Not a candidate for PCI (e.g., lesions are long or difficult to access) Failed PCI with ongoing chest pain History of diabetes mellitus When long-term benefits of CABG are superior to those of PCI Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Collaborative Care Acute Coronary Syndrome • Coronary surgical revascularization Coronary artery bypass graft (CABG) surgery • Requires sternotomy and cardiopulmonary bypass (CPB) • Uses arteries and veins for grafts Minimally invasive direct coronary artery bypass (MIDCAB) • Alternative to traditional CABG Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Cardiopulmonary Bypass From: Frank W. Sellke et al, Sabiston & Spencer Surgery of the Chest, ed 8, 2010, Saunders. Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Internal Mammary Artery and Saphenous Vein Grafts Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Radial Artery Graft • The radial artery is another conduit that can be used. • It is a thick muscular artery that is prone to spasm. • Perioperative calcium channel blockers and long-acting nitrates can control the spasms. • Patency rates at 5 years are as high as 84%. There have been no reports of extremity complications (e.g., hand ischemia, wound infection) following the removal of this artery. Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Collaborative Care Acute Coronary Syndrome • Coronary surgical revascularization Off-pump coronary artery bypass • Sternotomy but no CPB Robot-assisted surgery Transmyocardial laser revascularization • Indirect revascularization • High-energy laser creates channels in heart to allow blood flow Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Collaborative Care Acute Coronary Syndrome • Drug therapy IV nitroglycerin Morphine sulfate β-adrenergic blockers Angiotensin-converting enzyme inhibitors Antidysrhythmia drugs Cholesterol-lowering drugs Stool softeners Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Audience Response Question A patient is admitted to the coronary care unit following a cardiac arrest and successful cardiopulmonary resuscitation. When reviewing the health care provider’s admission orders, which order should the nurse question? a. Oxygen at 4 L/min per nasal cannula b. Morphine sulfate 2 mg IV every 10 minutes until the pain is relieved c. Tissue plasminogen activator (t-PA) 100 mg IV infused over 3 hours d. IV nitroglycerin at 5 mcg/minute and increase 5 mcg/minute every 3 to 5 minutes Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Collaborative Care Acute Coronary Syndrome • Nutritional therapy Initially NPO Progress to • Low salt • Low saturated fat • Low cholesterol Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Types of Fat in Food Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Nursing Management Chronic Stable Angina and ACS • Nursing assessment: subjective data Health history • CAD/chest pain/angina/ MI • Valve disease • Heart failure/cardiomyopathy, • Hypertension, diabetes, anemia, lung disease, hyperlipidemia Drugs History of present illness Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Nursing Management Chronic Stable Angina and ACS • Nursing assessment: subjective data Family history Indigestion/heartburn; nausea/vomiting Urinary urgency or frequency Straining at stool Palpitations, dyspnea, dizziness, weakness Chest pain Stress, depression, anger, anxiety Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Nursing Management Chronic Stable Angina and ACS • Nursing assessment: objective data Anxious, fearful, restless, distressed Cool, clammy, pale skin Tachycardia or bradycardia Pulsus alternans Pulse deficit Dysrhythmias S3, S4, ↑ or ↓ BP, murmur Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Case Study • • • iStockphoto/Thinkstock M.P. undergoes emergent PCI with additional stent placement, this time to his circumflex artery. He is admitted to the coronary critical care unit. Identify appropriate nursing diagnoses for M.P. Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Nursing Management Chronic Stable Angina and ACS • Nursing diagnoses Decreased cardiac output Acute pain Anxiety Activity intolerance Ineffective self-health management Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Nursing Management Chronic Stable Angina and ACS • Planning: overall goals Relief of pain Preservation of myocardium Immediate and appropriate treatment Effective coping with illnessassociated anxiety Participation in a rehabilitation plan Reduction of risk factors Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Nursing Management Chronic Stable Angina • Acute intervention Semi-Fowler’s position Supplemental oxygen Assess vital signs 12-lead ECG Administer a nitrate followed by an opioid analgesic, if needed Auscultate heart and breath sounds Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Nursing Management Chronic Stable Angina • Ambulatory and home care Provide reassurance Patient teaching • CAD and angina • Precipitating factors for angina • Risk factor reduction • Drugs Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Nursing Management Acute Coronary Syndrome • Acute intervention • Pain: nitroglycerin, morphine, oxygen • Continuous monitoring • ECG • ST segment • Heart and breath sounds • VS, pulse oximetry, I&O • Rest and comfort • Balance rest and activity • Begin cardiac rehabilitation Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Nursing Management Acute Coronary Syndrome • Acute intervention Anxiety reduction • Identify source and alleviate • Patient teaching important Emotional and behavioral reaction • Maximize patient’s social support systems • Consider open visitation Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Case Study • Describe appropriate nursing care of M.P. following his PCI. Copyright © 2014 by Mosby, an imprint of Elsevier Inc. iStockphoto/Thinkstock Nursing Management Acute Coronary Syndrome • Coronary revascularization: PCI Monitor for recurrent angina Frequent VS, including cardiac rhythm Monitor catheter insertion site for bleeding Neurovascular assessment Bed rest per institutional policy Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Nursing Management Acute Coronary Syndrome • Coronary revascularization: CABG ICU for first 24–36 hours Pulmonary artery catheter Intraarterial line Pleural/mediastinal chest tubes Continuous ECG ET tube with mechanical ventilation Epicardial pacing wires Urinary catheter NG tube Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Nursing Management Acute Coronary Syndrome • Complications related to CPB Bleeding and anemia from damage to RBCs and platelets Fluid and electrolyte imbalances Hypothermia as blood is cooled as it passes through the bypass machine Infections Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Nursing Management Acute Coronary Syndrome • CABG: postoperative nursing care Assess patient for bleeding Monitor hemodynamic status Assess fluid status Replace electrolytes PRN Restore temperature Monitor for atrial fibrillation (which is common) Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Nursing Management Acute Coronary Syndrome • CABG: postoperative nursing care Surgical site care • Radial artery harvest site • Leg incisions • Chest incision Pain management DVT prevention Pulmonary hygiene Cognitive dysfunction Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Nursing Management Acute Coronary Syndrome • Ambulatory and home care Cardiac rehabilitation Patient and caregiver teaching Physical activity • METs or Borg Scale • Monitor heart rate • Low-level stress test before discharge • Isometric versus isotonic activities Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Case Study iStockphoto/Thinkstock • When discussing activity restrictions and expectations after discharge with M.P., he assumes his sex life is now over as he does not want to die having sex with his wife. • How will you respond? Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Nursing Management Acute Coronary Syndrome • Ambulatory and home care Resumption of sexual activity • Teach when discuss other physical activity • Erectile dysfunction drugs contraindicated with nitrates • Prophylactic nitrates before sexual activity • When to avoid sex • Typically 7–10 days post MI or when patient can climb two flights of stairs Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Nursing Management Acute Coronary Syndrome • Evaluation Stable vital signs Relief of pain Decreased anxiety Realistic program of activity Effective management of therapeutic regimen Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Sudden Cardiac Death (SCD) • Unexpected death from cardiac causes • Abrupt disruption in cardiac function, resulting in loss of CO and cerebral blood flow • Most commonly caused by ventricular dysrhythmias • Structural heart disease • Conduction disturbances Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Sudden Cardiac Death (SCD) • No warning signs or symptoms if no MI • Prodromal symptoms if associated with MI Chest pain, palpitations, dyspnea Death usually within 1 hour of onset of acute symptoms Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Sudden Cardiac Death Nursing/Collaborative Management • Diagnostic workup to rule out or confirm MI Cardiac markers ECGs Treat accordingly • Cardiac catheterization • PCI or CABG Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Sudden Cardiac Death Nursing/Collaborative Management • 24-hour Holter monitoring • Exercise stress testing • Signal-averaged ECG • Electrophysiologic study (EPS) • Implantable cardioverterdefibrillator (ICD) • Antidysrhythmic drugs Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Sudden Cardiac Death Nursing/Collaborative Management • Patient teaching • Psychosocial adaptation “Brush with death” “Time bomb” mentality Additional issues • Driving restrictions • Role reversal • Change in occupation Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Audience Response Question The most significant factor in long-term survival of a patient with sudden cardiac death is a. Absence of underlying heart disease. b. Rapid institution of emergency services and procedures. c. Performance of perfect technique in resuscitation procedures. d. Maintenance of 50% of normal cardiac output during resuscitation efforts. Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Audience Response Question The nurse is caring for a patient who survived a sudden cardiac death. What should the nurse include in the discharge instructions? a. “Because you responded well to CPR, you will not need an implanted defibrillator.” b. “Your family members should learn how to perform CPR and practice these skills regularly.” c. “The most common way to prevent another arrest is to take your prescribed drugs.” d. “Since there was no evidence of a heart attack, you do not need to worry about another episode.” Copyright © 2014 by Mosby, an imprint of Elsevier Inc. Case Study iStockphoto/Thinkstock • What diagnostic testing would you expect the health care provider to order for M.P. ? Copyright © 2014 by Mosby, an imprint of Elsevier Inc.