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A Nutrient-Wide Association Study on Blood
PressureClinical Perspective
by Ioanna Tzoulaki, Chirag J. Patel, Tomonori Okamura, Queenie Chan, Ian J.
Brown, Katsuyuki Miura, Hirotsugu Ueshima, Liancheng Zhao, Linda Van Horn,
Martha L. Daviglus, Jeremiah Stamler, Atul J. Butte, John P.A. Ioannidis, and Paul
Elliott
Circulation
Volume 126(21):2456-2464
November 20, 2012
Copyright © American Heart Association, Inc. All rights reserved.
Procedure to systematically associate nutrients with blood pressure.
Ioanna Tzoulaki et al. Circulation. 2012;126:2456-2464
Copyright © American Heart Association, Inc. All rights reserved.
Volcano plot graphic showing the nutrient-wide associations with systolic blood pressure levels
in INTERMAP training set for nutrients received from foods and urine excretion markers (A) and
for nutrients received from foods and supplements (B). y axis indicates −log10(P value) of the
adjusted linear regression coefficient for each of the nutrients.
Ioanna Tzoulaki et al. Circulation. 2012;126:2456-2464
Copyright © American Heart Association, Inc. All rights reserved.
Volcano plot graphic showing the nutrient-wide associations with diastolic blood pressure levels
in INTERMAP training set for nutrient received from foods and urine excretion markers (A) and
for nutrients received for foods and supplements (B). y axis indicates −log10(P value) of the
adjusted linear regression coefficient for each of the nutrients.
Ioanna Tzoulaki et al. Circulation. 2012;126:2456-2464
Copyright © American Heart Association, Inc. All rights reserved.
Pearson coefficient correlation heatmap showing all nutrients and potential confounders
examined in (A) INTERMAP total population and (B) NHANES total population.
Ioanna Tzoulaki et al. Circulation. 2012;126:2456-2464
Copyright © American Heart Association, Inc. All rights reserved.