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Transcript 
Androgen Receptor Promotes Sex-Independent
Angiogenesis in Response to Ischemia and Is Required for
Activation of Vascular Endothelial Growth Factor Receptor
SignalingClinical Perspective
by Sumiko Yoshida, Ken-ichi Aihara, Yasumasa Ikeda, Yuka Sumitomo-Ueda, Ryoko
Uemoto, Kazue Ishikawa, Takayuki Ise, Shusuke Yagi, Takashi Iwase, Yasuhiro
Mouri, Matomo Sakari, Takahiro Matsumoto, Ken-ichi Takeyama, Masashi Akaike,
Mitsuru Matsumoto, Masataka Sata, Kenneth Walsh, Shigeaki Kato, and Toshio
Matsumoto
Circulation
Volume 128(1):60-71
July 2, 2013
Copyright © American Heart Association, Inc. All rights reserved.
Increased hind-limb autoamputation in both male and female androgen receptor knockout
(ARKO) mice after femoral arteriectomy.
Sumiko Yoshida et al. Circulation. 2013;128:60-71
Copyright © American Heart Association, Inc. All rights reserved.
Accelerated cellular apoptosis in ischemic skeletal muscles of both male and female androgen
receptor knockout (ARKO) mice.
Sumiko Yoshida et al. Circulation. 2013;128:60-71
Copyright © American Heart Association, Inc. All rights reserved.
Impaired blood flow recovery and reduced capillary density in both male and female androgen
receptor knockout (ARKO) mice after ischemia.
Sumiko Yoshida et al. Circulation. 2013;128:60-71
Copyright © American Heart Association, Inc. All rights reserved.
Attenuated angiogenic potency in endothelial cells but not in bone marrow (BM) progenitor cells
of male androgen receptor knockout (ARKO) mice.
Sumiko Yoshida et al. Circulation. 2013;128:60-71
Copyright © American Heart Association, Inc. All rights reserved.
Aberrant expression and activation of angiogenesis-related factors in ischemic muscles of male
and female androgen receptor knockout (ARKO) mice.
Sumiko Yoshida et al. Circulation. 2013;128:60-71
Copyright © American Heart Association, Inc. All rights reserved.
Reduced phosphorylation of factors involved in cell survival and angiogenesis in ischemic
muscles of male and female androgen receptor knockout (ARKO) mice.
Sumiko Yoshida et al. Circulation. 2013;128:60-71
Copyright © American Heart Association, Inc. All rights reserved.
Association between androgen receptor (AR) and vascular endothelial growth factor (VEGF)
receptor signaling pathway in human umbilical vein endothelial cells (HUVECs).
Sumiko Yoshida et al. Circulation. 2013;128:60-71
Copyright © American Heart Association, Inc. All rights reserved.
Schematic diagram of the associations between androgen receptor (AR) and vascular
endothelial growth factor (VEGF) receptor signaling pathways.
Sumiko Yoshida et al. Circulation. 2013;128:60-71
Copyright © American Heart Association, Inc. All rights reserved.
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