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Stage 10 Human Embryo (~ 22 Days) Somite Formation from Pre-Somitic Mesoderm Somite Formation and Hairy Gene expression Hairy Gene Expression Homeotic (Hox) Genes Hox a Hox b Hox c Hox d Hox Gene Expression Along A/P Axis (Posterior margin of Hox Genes Expression) “Hox Code” Concept Hoxc8 Deletion in Mouse Forelimb Development in chick and mouse Limb Bud Development Sonichedgehog (Shh) Expression in Limb Bud Ectopic Application of Shh Protein Hox Gene Expression in Limb Bud Hox a genes Hox d genes Synpolydactyl Phenotype Hoxd13 mutation Digit Formation Programmed Cell Death Programmed Cell Death Pathway (BMP?)