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Fibrin-based clot formation as an early and rapid biomarker for progression of postpartum hemorrhage: a prospective study by Peter W. Collins, Graeme Lilley, Daniel Bruynseels, David Burkett-St. Laurent, Rebecca Cannings-John, Elizabeth Precious, Vincent Hamlyn, Julia Sanders, Raza Alikhan, Rachel Rayment, Alexandra Rees, Abigail Kaye, Judith E. Hall, Shantini Paranjothy, Andrew Weeks, and Rachel E. Collis Blood Volume 124(11):1727-1736 September 11, 2014 ©2014 by American Society of Hematology The women recruited into the study are shown compared with the number of women delivered during the study period as reported in the Cardiff Maternity Database. *The number of women experiencing bleeds of ≥2000 mL among all women delivering during the study ... Peter W. Collins et al. Blood 2014;124:1727-1736 ©2014 by American Society of Hematology ROC curves for fibrinogen and Fibtem A5. Peter W. Collins et al. Blood 2014;124:1727-1736 ©2014 by American Society of Hematology Time of bleeds and stay on HDU. (A) Time from the recognition of abnormal bleeding to hemostatic control. Peter W. Collins et al. Blood 2014;124:1727-1736 ©2014 by American Society of Hematology The time to first unit of RBC, fourth unit of RBC, and first unit of FFP. (A-C) All women in the study. Peter W. Collins et al. Blood 2014;124:1727-1736 ©2014 by American Society of Hematology