Download Powerpoint

Survey
yes no Was this document useful for you?
   Thank you for your participation!

* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project

page
1
page
2
page
3
page
4
page
5
page
6
page
7
page
8
page
9
Document related concepts
no text concepts found
Transcript 
Angiotensin AT1 Receptor Inhibition
by Ellen O. Weinberg, Min Ae Lee, Marilyn Weigner, Klaus Lindpaintner, Sanford P.
Bishop, Claude R. Benedict, Kalon K. L. Ho, Pamela S. Douglas, Edward
Chafizadeh, and Beverly H. Lorell
Circulation
Volume 95(6):1592-1600
March 18, 1997
Copyright © American Heart Association, Inc. All rights reserved.
Tail-cuff blood pressure measurements in rats with aortic stenosis during 15 weeks of treatment
with an AT1 blocker (LVH/AT), amlodipine (LVH/Ca), or no drug (LVH).
Ellen O. Weinberg et al. Circulation. 1997;95:1592-1600
Copyright © American Heart Association, Inc. All rights reserved.
In vivo LVSPs (top) and LV diastolic pressures (bottom) measured in intact animals at the end of
the 15-week treatment period.
Ellen O. Weinberg et al. Circulation. 1997;95:1592-1600
Copyright © American Heart Association, Inc. All rights reserved.
Perfusion-fixed myocardial tissues from the LV subendocardial region of animals from the
sham-operated (Sham) (A), LVH untreated (B), LVH AT1-blocker–treated (C), and LVH amlodipinetreated (D) groups.
Ellen O. Weinberg et al. Circulation. 1997;95:1592-1600
Copyright © American Heart Association, Inc. All rights reserved.
Perfusion-fixed subendomyocardial tissue embedded in glycol methacrylate and stained with
silver as used for measurement of cross-sectional area.
Ellen O. Weinberg et al. Circulation. 1997;95:1592-1600
Copyright © American Heart Association, Inc. All rights reserved.
Kaplan-Meier survival curves for the group with untreated aortic stenosis (LVH), the AT1blocker–treated aortic stenosis group (LVH/AT), and the amlodipine-treated aortic stenosis
group (LVH/Ca).
Ellen O. Weinberg et al. Circulation. 1997;95:1592-1600
Copyright © American Heart Association, Inc. All rights reserved.
Relation between LVEDP vs balloon volume as an index of LV diastolic chamber distensibility.
Ellen O. Weinberg et al. Circulation. 1997;95:1592-1600
Copyright © American Heart Association, Inc. All rights reserved.
Relation between LV developed pressure per gram (LV DevP/g) vs perfusate calcium
concentration (mmol/L) in untreated LVH group (LVH), AT1-blocker–treated group (LVH/AT), and
amlodipine-treated group (LVH/Ca) at an identical LV preload (balloon volume of 0.2 mL).
Ellen O. Weinberg et al. Circulation. 1997;95:1592-1600
Copyright © American Heart Association, Inc. All rights reserved.
Linear regression relation between LV ACE mRNA levels and in vivo LVEDP (left) and ACE mRNA
levels and LVSP (right) among the aortic-banded rats. •, No treatment; ○, AT1 blocker; and ▴,
amlodipine.
Ellen O. Weinberg et al. Circulation. 1997;95:1592-1600
Copyright © American Heart Association, Inc. All rights reserved.
Related documents