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Matthew Evan Larkum
Sündinud Cambridge’is, UK
Lõpetanud Sydney ülikooli 1991
Tema mentor – doktori- ja järeldoktori töö juhendaja -- on Nobeli meditsiini- ja füsioloogia
preemia laureaat (1991) Bert Sakmann
Matthew Larkum’i tähtsamad töökohad:
1997-2003 – Max Planck’i Meditsiiniuuringute Instituut, Heidelberg
2004-2011 – Berni ülikool
2011 - k-a – Humboldti ülikool ja Neuroscience Research Center (Berliin)
Kutsutud loengud ja õppetoad: Cold Spring Harbor Labs, UCL, Karolinska Institute,
Cambridge, Dartmouth, Melbourne, Copenhagen, etc.
Uurimisteemad:
Neurobioloogia, aju rakubioloogia, närvivõrgud ja neurokomputatsioon, ajukoore
püramiidrakkude dendriitide bioelektriliste protsesside uurimine, anesteetikumide mõju
raku-taseme protsessidele, optiliste meetodite arendamine ja rakendamine kortikaalsete
neuronite aktiivsuse uurimiseks (sj in vivo), tajunähtuste modelleerimine mikrovõrgustike
aktiivsuse abil. Inimkatsed, loomkatsed; uurimused in vivo, in vitro, in silico.
Matthew Larkum on maailma juhtivaid spetsialiste kaltsiumiioonide vahendatud
dendriidispaikide alal.
Tunnustused:
Šveitsi rahvusliku teadusfondi professuur (2004)
Theodor Koch’i auhind (2006)
Pfizer’i auhind parima neuroteadusliku töö eest (2007)
Robert Bing Prize (2010)
Publitseerinud korduvalt ajakirjades Nature, Science, Nature Neuroscience, Trends in
Neurosciences, PNAS, Neuron, The Journal of Neuroscience, Current Opinion in
Neurobiology, Cerebral Cortex, etc. Töid, millele on viidatud üle 100 korra on avaldanud
14.
Valik publikatsioone:
Larkum, M.E. (2013). The yin and yang of cortical layer 1. Nature Neuroscience. 2:16, DOI:
10.1038/nn.3317.
Larkum, M. (2013). A cellular mechanism for cortical associations: an organizing principle for the
cerebral cortex. Trends in Neurosciences, 36, 141-151.
Palmer, L.M., Schulz, J.M., Murphy, S.C., Ledergerber, D., Murayama, M., & Larkum, M.E.
(2012). The Cellular Basis of GABAB-Mediated Interhemispheric Inhibition. Science, 335,
989-993.
Palmer, L., Murayama, M., & Larkum, M. (2012). Inhibitory regulation of dendritic activity in vivo.
Frontiers in Neural Circuits 6:26. doi:10.3389/fncir.2012.00026
Palmer, L.M., Schulz, J.M., Murphy, S.C., Ledergerber, D., Murayama, M., & Larkum, M.E.
(2012). The cellular basis of GABAB-mediated interhemispheric inhibition. Science, 335,
989-993.
Granato, A., Palmer, L.M., De Giorgio, A., Tavian, D., & Larkum, M.E. (2013). Early exposure to
alcohol leads to permanent impairment of dendritic excitability in neocortical pyramidal
neurons. Journal of Neuroscience, 32, 1377-1282.
Murayama, M., Perez-Garci, E., Nevian, T., Bock, T., Senn, W., & Larkum, M.E. (2009). Dendritic
encoding of sensory stimuli controlled by deep cortical interneurons. Nature, 457, 11371141.
Murayama, M., & Larkum, M.E. (2009). In vivo dendritic calcium imaging with a fiberoptic
periscope system. Nature Protocols, 4, 1551-1559.
Murayama, M., & Larkum, M.E. (2009). Enhanced dendritic activity in awake rats. PNAS, 106,
20482-6.
Larkum, M.E., Nevian, T., Sandler, M., Polsky, A., & Schiller, J. (2009). Synaptic integration in tuft
dendrites of layer 5 pyramidal neurons: a new unifying principle. Science, 325, 756-760.
Larkum, M.E., & Nevian, T. (2008). Synaptic clustering by dendritic signaling mechanisms. Current
Opinion in Neurobiology, 18, 321-331.
Nevian, T., Larkum, M.E., Polsky, A., & Schiller, J. (2007). Properties of basal dendrites of layer 5
pyramidal neurons: a direct patch-clamp recording study. Nature Neuroscience, 10, 206214.
Pérez-Garci, E., Gassmann, M., Bettler, B., &Larkum, M.E. (2006). The GABA isoform mediates
B1b
2+
long-lasting inhbition of dendritic Ca spikes in layer 5 somatosensory pyramidal neurons.
Neuron, 50, 603-616.
Hasan, M.T., Friedrich, R.W., Euler, T., Larkum, M.E., Giese, G., Both, M., Duebel, J., Waters, J.,
Bujard, H., Griesbeck, O., Tsien, R.Y., Nagai, T., Miyawaki, A., & Denk, W. (2004).
2+
Functional fluorescent Ca indicator proteins in transgenic mice under TET control. PLoS
Biology, 2, 763-775.
London, M., Shribman, A., Häusser, M., Larkum, M.E., & Segev, I. (2002). Synaptic information
efficacy: Bridging the cleft between biophysics and function. Nature Neuroscience, 5, 332340.
Larkum, M.E., Kaiser, K.M.M., & Sakmann, B. (1999). Calcium electrogenesis in distal apical
dendrites of layer 5 pyramidal cells at a critical frequency of back-propagating action
potentials. PNAS, 96, 14600-14604.
Larkum, M.E., Zhu, J.J., & Sakmann, B. (1999) A new mechanism for coupling inputs arriving at
different cortical layers. Nature, 398, 338-341.
Lütcke, H., Murayama, M., Hahn, T., Margolis, D.J., Astori, S., zum Alten Borgloh, S.M., Göbel,
W., Yang, Y., Tang, W., Kügler, S., Sprengel, R., Nagai, T., Miyawaki, A., Larkum, M.E.,
Helmchen, F., & Hasan, M.T. (2010). Optical recording of neuronal activity with a
genetically-encoded calcium indicator in anesthetized and freely moving mice. Frontiers in
Neural Circuits 4:9. doi:10.3389/fncir.2010.00009