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Osmoregulation Biological negative feedback systems can be controlled by the nervous system or the endocrine system (or both). Osmoregulation - regulation of water and ion balance in the body - role of the kidney The functional unit of the kidney is called a nephron. The nephron is responsible for: • filtering the blood • keeping the waste (urea) in the filtrate • reclaiming water and nutrients (e.g. Na+, amino acids, glucose) The process of water reclamation is controlled by ADH (antidiuretic hormone) and includes the following steps: 1) Glomerular Filtration 2) Tubular Reabsorption 3) Collection and secretion of wastes ADH (Antidiuretic Hormone) Diuresis: urine production Diuretic: increased urine production nephron is less permeable so less water is reabsorbed from nephrons into the blood Anti-Diuretic: decreased urine production nephrons becomes more permeable so more water is reabsorbed from nephron into blood Increased ADH → decreased urine → decreased water loss ADH will be produced by the body if: 1) the outside temperature is hot 2) liquid intake decreases 3) increase in physical activity Stimulus (decreased blood pressure) ↓ Receptor (pressure receptors in blood vessels) ↓ Regulator (Brain - hypothalamus) ↓ Effector (ADH released and enters the collecting ducts) ↓ Response (nephrons permeability increases, more water is reabsorbed into blood and blood pressure increases, urine volume decreases)