Lamictal (lamotrigine)
... Lamotrigine is FDA approved for adjunctive therapy in the treatment of generalized seizures of Lennox-Gastaut syndrome, primary generalized tonic-clonic seizures, and partial seizures in adults and children ≥2 years of age; conversion to monotherapy in adults with partial seizures who are receiving ...
... Lamotrigine is FDA approved for adjunctive therapy in the treatment of generalized seizures of Lennox-Gastaut syndrome, primary generalized tonic-clonic seizures, and partial seizures in adults and children ≥2 years of age; conversion to monotherapy in adults with partial seizures who are receiving ...
Mood Stabilizers - LifeNet Psychiatry
... serendipity. With certain types of epilepsy, individuals sometimes manifest psychiatric symptoms, including hallucinations, agitation, and changes in mood. When such patients were treated with phenytoin (Dilantin), an anticonvulsant, their seizures, as well as their psychiatric symptoms, were stabil ...
... serendipity. With certain types of epilepsy, individuals sometimes manifest psychiatric symptoms, including hallucinations, agitation, and changes in mood. When such patients were treated with phenytoin (Dilantin), an anticonvulsant, their seizures, as well as their psychiatric symptoms, were stabil ...
PHL 322 Antiepilepti..
... – Is a prodrug whose actions are similar to those of carbamazepine; it has a short half-life of 1—2 hour. – Its activity is due to a 10-hydroxy metabolite with a half-life of 10 hours. – Fewer adverse effects than CBZ, phenytoin ...
... – Is a prodrug whose actions are similar to those of carbamazepine; it has a short half-life of 1—2 hour. – Its activity is due to a 10-hydroxy metabolite with a half-life of 10 hours. – Fewer adverse effects than CBZ, phenytoin ...
Efficacy and tolerability of the new antiepileptic drugs I - Doctors
... Metabolic acidosis, weight loss, ...
... Metabolic acidosis, weight loss, ...
Mechanism of Action
... An awareness of the antiepileptic drugs available, including their mechanisms of action, pharmacokinetics, potential for drugdrug interactions, and adverse effects, is essential for successful therapy ...
... An awareness of the antiepileptic drugs available, including their mechanisms of action, pharmacokinetics, potential for drugdrug interactions, and adverse effects, is essential for successful therapy ...
Depakote - UnitedHealthcareOnline.com
... (a) Documented history of an inadequate response to the corresponding release product as evidenced by one of the following: i. Change in seizure frequency from baseline ii. Breakthrough seizures not explained by medication nonadherence or significant provoking factor iii. Status epilepticus -OR(b) D ...
... (a) Documented history of an inadequate response to the corresponding release product as evidenced by one of the following: i. Change in seizure frequency from baseline ii. Breakthrough seizures not explained by medication nonadherence or significant provoking factor iii. Status epilepticus -OR(b) D ...
Seizure - WordPress.com
... hypersensitivity reaction. Although the risk of rash may be diminished by introducing the drug slowly, pediatric patients are at greatest risk, some studies suggest that a potentially life-threatening dermatitis will develop in 1–2% of pediatric patients. Pharmacokinetics Lamotrigine is almost compl ...
... hypersensitivity reaction. Although the risk of rash may be diminished by introducing the drug slowly, pediatric patients are at greatest risk, some studies suggest that a potentially life-threatening dermatitis will develop in 1–2% of pediatric patients. Pharmacokinetics Lamotrigine is almost compl ...
bnn0998 color - Bipolar Network News
... neuroleptics block dopamine receptors, resulting in a functional deficit of dopamine activity or a drug-induced mild parkinsonism in many instances. The older neuroleptics block dopamine receptors in the areas of brain involved with motor functioning (the striatum) as well as those that regulate moo ...
... neuroleptics block dopamine receptors, resulting in a functional deficit of dopamine activity or a drug-induced mild parkinsonism in many instances. The older neuroleptics block dopamine receptors in the areas of brain involved with motor functioning (the striatum) as well as those that regulate moo ...
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... • Starting dose and titration rate – Tolerance development – Early detection of toxicities – Side effects may occur within the standard range • Statistical estimate • Inter‐individual differences • Effects associated with peak levels (timing of doses) Guerrini R, et al. Drug Safety 2012;35(7):519‐5 ...
... • Starting dose and titration rate – Tolerance development – Early detection of toxicities – Side effects may occur within the standard range • Statistical estimate • Inter‐individual differences • Effects associated with peak levels (timing of doses) Guerrini R, et al. Drug Safety 2012;35(7):519‐5 ...
New Medications for Epilepsy - Turner White Communications
... seen in some patients, and nephrolithiasis occurs in 1.5% of patients.6 Lamotrigine (Lamictal) In 1995, lamotrigine was approved by the FDA as adjunctive therapy for partial onset seizures in adults.7,8 The drug also appears to have efficacy in primary generalized seizures, including absence seizure ...
... seen in some patients, and nephrolithiasis occurs in 1.5% of patients.6 Lamotrigine (Lamictal) In 1995, lamotrigine was approved by the FDA as adjunctive therapy for partial onset seizures in adults.7,8 The drug also appears to have efficacy in primary generalized seizures, including absence seizure ...
March - Behavioral Health Care Services
... Two large, randomized, multicenter, double-blind, placebocontrolled trials of 18 months’ duration compared the efficacy and tolerability of lamotrigine and lithium to placebo in delaying relapse or recurrence of mood episodes in patients with bipolar I disorder. Both studies were supported by GlaxoS ...
... Two large, randomized, multicenter, double-blind, placebocontrolled trials of 18 months’ duration compared the efficacy and tolerability of lamotrigine and lithium to placebo in delaying relapse or recurrence of mood episodes in patients with bipolar I disorder. Both studies were supported by GlaxoS ...
Psychopharmacology of Mood Disorders
... – similar safety and side effect profile to SSRI’s – so-called dual action purported to be more effective – limited evidence from meta-analyses of superior efficacy vs. SSRI’s ...
... – similar safety and side effect profile to SSRI’s – so-called dual action purported to be more effective – limited evidence from meta-analyses of superior efficacy vs. SSRI’s ...
MEDICATION GUIDE LAMOTRIGINE TABLETS, USP (la moe′ tri
... are taking oral contraceptives (birth control pills) or other female hormonal medicines. Do not start or stop taking birth control pills or other female hormonal medicine until you have talked with your healthcare provider. Tell your healthcare provider if you have any changes in your menstrual patt ...
... are taking oral contraceptives (birth control pills) or other female hormonal medicines. Do not start or stop taking birth control pills or other female hormonal medicine until you have talked with your healthcare provider. Tell your healthcare provider if you have any changes in your menstrual patt ...
Status Epilepticus was defined by the International Classification of
... Initiate therapy with an appropriate dose. Monitor AED levels when appropriate. ...
... Initiate therapy with an appropriate dose. Monitor AED levels when appropriate. ...
Bipolar Disorder
... therapy is known to: a) induce tremor b) cause urinary frequency c) be associated with thirst d) increase suicide risk e) induce nausea, vomiting, and diarrhea ...
... therapy is known to: a) induce tremor b) cause urinary frequency c) be associated with thirst d) increase suicide risk e) induce nausea, vomiting, and diarrhea ...
MEDICATION GUIDE LAMOTRIGINE TABLETS, USP 25 mg
... 1. together with other medicines to treat certain types of seizures (partial-onset seizures, primary generalized tonic-clonic seizures, generalized seizures of Lennox-Gastaut syndrome) in people aged 2 years and older. 2. alone when changing from one other medicins used to treat partial-onset seizur ...
... 1. together with other medicines to treat certain types of seizures (partial-onset seizures, primary generalized tonic-clonic seizures, generalized seizures of Lennox-Gastaut syndrome) in people aged 2 years and older. 2. alone when changing from one other medicins used to treat partial-onset seizur ...
Relationship between plasma and brain levels and
... levels and the induced pharmacological response. In spite of the microdialysis study carried out by Walker et al. (2000), the present data represent additional information for the characterization of lamotrigine neuropharmacokinetics in rats, since it is important to compare the extracellular with t ...
... levels and the induced pharmacological response. In spite of the microdialysis study carried out by Walker et al. (2000), the present data represent additional information for the characterization of lamotrigine neuropharmacokinetics in rats, since it is important to compare the extracellular with t ...
Antiepileptic drugs
... Nature of Epilepsy • The neurochemical basis of the abnormal discharge is not well understood. It may be associated with enhanced excitatory amino acid transmission, impaired inhibitory transmission, or abnormal electrical properties of the affected cells. The glutamate content in areas surroundin ...
... Nature of Epilepsy • The neurochemical basis of the abnormal discharge is not well understood. It may be associated with enhanced excitatory amino acid transmission, impaired inhibitory transmission, or abnormal electrical properties of the affected cells. The glutamate content in areas surroundin ...
Epilepsy - Back to Medical School
... reduce AEs Rash common, sometimes severe and associated with StevenJohnson’s syndrome Blood dyscrasias ...
... reduce AEs Rash common, sometimes severe and associated with StevenJohnson’s syndrome Blood dyscrasias ...
RECHALLENGE WITH LAMOTRIGINE AFTER A RASH
... patient adherence.13 This profile is particularly relevant in bipolar disorder, where rates of adherence approach only 50 percent31 and rates of mortality approach those associated ...
... patient adherence.13 This profile is particularly relevant in bipolar disorder, where rates of adherence approach only 50 percent31 and rates of mortality approach those associated ...
New Antiepileptic Drugs
... Equally effective as older AEDs Most better tolerated than older AEDs Most have fewer interactions with other medications than older ...
... Equally effective as older AEDs Most better tolerated than older AEDs Most have fewer interactions with other medications than older ...
Treating Epilepsy with newer anti-epileptic drugs
... Randomized Dose Group *Comparison to placebo Faught E et al. Neurology 46:1684, 1996 ...
... Randomized Dose Group *Comparison to placebo Faught E et al. Neurology 46:1684, 1996 ...
AEDs - BC Epilepsy Society
... – No clinical relevant changes in the plasma concentrations of concomitant AED’s (carbamazepine, valproic acid, phenytoin, gabapentin, lamotrigine, levetiracetam, oxcarbazepine or zonisamide). – No clinical relevant interaction with digoxin, metformin, omeprazole (CYP2C19 inhibitor), or ethinyl estr ...
... – No clinical relevant changes in the plasma concentrations of concomitant AED’s (carbamazepine, valproic acid, phenytoin, gabapentin, lamotrigine, levetiracetam, oxcarbazepine or zonisamide). – No clinical relevant interaction with digoxin, metformin, omeprazole (CYP2C19 inhibitor), or ethinyl estr ...
4-15-2016 PPT
... • You receive a call from a patient on carbamazepine who is experiencing a small rash that started this morning. You should tell her it will likely go away in a few days. If it doesn’t, then follow up with her physician. • A patient experienced SJS syndrome while on carbamazepine. Switching to oxcar ...
... • You receive a call from a patient on carbamazepine who is experiencing a small rash that started this morning. You should tell her it will likely go away in a few days. If it doesn’t, then follow up with her physician. • A patient experienced SJS syndrome while on carbamazepine. Switching to oxcar ...
Lamotrigine
Lamotrigine /ləˈmoʊtrɨˌdʒiːn/, marketed in most of the world as Lamictal /ləˈmɪktəl/ by GlaxoSmithKline, is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. It is also used off-label as an adjunct in treating clinical depression. For epilepsy, it is used to treat focal seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Like many other anticonvulsant medications, lamotrigine also seems to act as an effective mood stabilizer, and has been the first US Food and Drug Administration (FDA)-approved drug for this purpose since lithium, a drug approved almost 30 years earlier. It is approved for the maintenance treatment of bipolar type I.Chemically unrelated to other anticonvulsants (due to lamotrigine being a phenyltriazine), lamotrigine has many possible side-effects. Lamotrigine is generally accepted to be a member of the sodium channel blocking class of antiepileptic drugs, but it could have additional actions since it has a broader spectrum of action than other sodium channel antiepileptic drugs such as phenytoin and carbamazepine and is effective in the treatment of the depressed phase of bipolar disorder, whereas other sodium channel blocking antiepileptic drugs are not. In addition, lamotrigine shares few side-effects with other, unrelated anticonvulsants known to inhibit sodium channels, which further emphasises its unique properties. Lamotrigine is inactivated by glucuronidation in the liver.