Rationale for Net and Absolute PI scores Pathway/processes may
... Pathway/processes may contain both “activators” and “inhibitors” of the biological endpoint. Therefore, it is of interest to determine whether or not perturbing such a pathway will tend towards an inhibitory or an activation effect. For this reason a net score is calculated. We use the absolute scor ...
... Pathway/processes may contain both “activators” and “inhibitors” of the biological endpoint. Therefore, it is of interest to determine whether or not perturbing such a pathway will tend towards an inhibitory or an activation effect. For this reason a net score is calculated. We use the absolute scor ...
An Improved Molecular Assay for Tritrichomonas Fetus
... identification of numerous causative mutations, the pathogenic and genetic processes are still poorly understood, making a large animal model of familial HCM especially useful. Causative mutations have been identified in Maine Coon and Ragdoll cats, however, HCM is thought to be inherited in other b ...
... identification of numerous causative mutations, the pathogenic and genetic processes are still poorly understood, making a large animal model of familial HCM especially useful. Causative mutations have been identified in Maine Coon and Ragdoll cats, however, HCM is thought to be inherited in other b ...
Supplementary Materials and Figures Legends (doc 58K)
... The Discovery sample whole-genome scan was performed using the Illumina Infinium Human1 (with 109,365 gene-centered SNPs) and the HumanCNV370-Duo DNA Analysis BeadChip (with the standard content featured on HumanHap300-Duo with an additional 52,167 markers designed to target nearly 14,000 copy numbe ...
... The Discovery sample whole-genome scan was performed using the Illumina Infinium Human1 (with 109,365 gene-centered SNPs) and the HumanCNV370-Duo DNA Analysis BeadChip (with the standard content featured on HumanHap300-Duo with an additional 52,167 markers designed to target nearly 14,000 copy numbe ...
Getting Started
... information in a way that can be read by both humans and computers. necessary for high-throughput “omics” datasets allows data sharing across databases ...
... information in a way that can be read by both humans and computers. necessary for high-throughput “omics” datasets allows data sharing across databases ...
Real-time qPCR Experimental Design Considerations
... Gene Expression experiments are typically designed to test a hypothesis that a difference in gene expression exists between groups of biological subjects exposed to different ...
... Gene Expression experiments are typically designed to test a hypothesis that a difference in gene expression exists between groups of biological subjects exposed to different ...
Small Nucleolar RNA
... • Loss of either the paternal or maternal copy of this region leads to two neurological disorders: Prader-Willi or Angelman ...
... • Loss of either the paternal or maternal copy of this region leads to two neurological disorders: Prader-Willi or Angelman ...
The Macrophage Colony-Stimulating Factor 1Response Signature
... Imaging, Inc.)], are available for all stained cores through the accompanying Web site.7 Additional detailed information on the antibodies used, staining procedure, and scoring technique can be found in Supplementary Materials and Methods. Institutional review board approval was obtained for these s ...
... Imaging, Inc.)], are available for all stained cores through the accompanying Web site.7 Additional detailed information on the antibodies used, staining procedure, and scoring technique can be found in Supplementary Materials and Methods. Institutional review board approval was obtained for these s ...
Modified Mendelian ratios
... Duplicate gene action • Spring growth is the result of duplicate gene action between two independent genes S and H • Spring growth: S_; H_ , S_; hh , ss; H_ • Winter growth: ss;hh • In duplicate gene action the dominant phenotype is evident when at least one dominant allele is present at each locus, ...
... Duplicate gene action • Spring growth is the result of duplicate gene action between two independent genes S and H • Spring growth: S_; H_ , S_; hh , ss; H_ • Winter growth: ss;hh • In duplicate gene action the dominant phenotype is evident when at least one dominant allele is present at each locus, ...
See a Sample
... Early comparative genomics Comparative genomics prior to obtaining full genome sequence: Genome size Compared DNA content among species ...
... Early comparative genomics Comparative genomics prior to obtaining full genome sequence: Genome size Compared DNA content among species ...
benfey_ch10
... Early comparative genomics Comparative genomics prior to obtaining full genome sequence: Genome size Compared DNA content among species ...
... Early comparative genomics Comparative genomics prior to obtaining full genome sequence: Genome size Compared DNA content among species ...
Chi Square values have been published by statisticians in a table
... The classical study of single gene traits is by pedigree analysis. Over 7000 human single gene traits have been recognized, many also assigned to the particular chromosome on which they reside. The Human Genome Project will uncover many more genes and further study in proteomics will assign function ...
... The classical study of single gene traits is by pedigree analysis. Over 7000 human single gene traits have been recognized, many also assigned to the particular chromosome on which they reside. The Human Genome Project will uncover many more genes and further study in proteomics will assign function ...
Targeted gene inactivation in Clostridium phytofermentans shows
... resistance marker, an origin of replication that can be selectively lost, and a designed group II intron for efficient, targeted chromosomal insertions without selection. We applied these methods to disrupt the cphy3367 gene, which encodes the sole family nine glycoside hydrolase (GH9) in the C. phy ...
... resistance marker, an origin of replication that can be selectively lost, and a designed group II intron for efficient, targeted chromosomal insertions without selection. We applied these methods to disrupt the cphy3367 gene, which encodes the sole family nine glycoside hydrolase (GH9) in the C. phy ...
Genes for two multicopper proteins required for Fe(III) oxide
... Previous studies have shown that Geobacter sulfurreducens requires the outer-membrane, multicopper protein OmpB for Fe(III) oxide reduction. A homologue of OmpB, designated OmpC, which is 36 % similar to OmpB, has been discovered in the G. sulfurreducens genome. Deletion of ompC inhibited reduction ...
... Previous studies have shown that Geobacter sulfurreducens requires the outer-membrane, multicopper protein OmpB for Fe(III) oxide reduction. A homologue of OmpB, designated OmpC, which is 36 % similar to OmpB, has been discovered in the G. sulfurreducens genome. Deletion of ompC inhibited reduction ...
Patterns of gene action in plant development revealed by enhancer
... We have utilized a two-element transposon system in which transgenic Arabidopsis plants carrying an immobilized Ac element are crossed to plants carrying one of two different Ds elements (i.e., nonautonomous Ac elements). The i m m o b i l i z e d A c element contains a cauliflower mosaic virus (CaM ...
... We have utilized a two-element transposon system in which transgenic Arabidopsis plants carrying an immobilized Ac element are crossed to plants carrying one of two different Ds elements (i.e., nonautonomous Ac elements). The i m m o b i l i z e d A c element contains a cauliflower mosaic virus (CaM ...
review - University of Oxford
... bubble, and resulting supercoils are not shown). In the conventional model for transcription (left), the active site in a tracking polymerase moves around and along as it reads a helical strand; the resulting transcript (red) is entwined about the template and must be untwined exactly the right numb ...
... bubble, and resulting supercoils are not shown). In the conventional model for transcription (left), the active site in a tracking polymerase moves around and along as it reads a helical strand; the resulting transcript (red) is entwined about the template and must be untwined exactly the right numb ...
Mitochondrialproteinphylogenyjoins myriapods with chelicerates
... tree included a monophyletic Pancrustacea, branch-support analysis yielded little resolution with regard to the position of the Branchiopoda. The most striking result was a strong support for a sister group relationship between the myriapods and chelicerates with branch-support values equalling thos ...
... tree included a monophyletic Pancrustacea, branch-support analysis yielded little resolution with regard to the position of the Branchiopoda. The most striking result was a strong support for a sister group relationship between the myriapods and chelicerates with branch-support values equalling thos ...
The degenerate Y chromosome – can
... and transcribed sequences, with no open reading frames (NORFs), they contain. ...
... and transcribed sequences, with no open reading frames (NORFs), they contain. ...
Clinical Feature: Diagnosis and Genetic Variance in Familial
... Dutch Lipid Clinic Network requires one additional clinical criterion. There is relatively weak concordance between phenotype and genotype. Testing for the genetic defect is a complex, expensive process with limited availability. Careful choice of appropriate candidates is advisable.2,11 A widely us ...
... Dutch Lipid Clinic Network requires one additional clinical criterion. There is relatively weak concordance between phenotype and genotype. Testing for the genetic defect is a complex, expensive process with limited availability. Careful choice of appropriate candidates is advisable.2,11 A widely us ...
슬라이드 1
... •SLG (S-Locus Glycoprotein) which encodes part of a receptor present in the cell wall of the stigma; •SRK (S-Receptor Kinase), which encodes the other part of the receptor. Kinases attach phosphate groups to other proteins. SRK is transmembrane protein embedded in the plasma membrane of the stigma c ...
... •SLG (S-Locus Glycoprotein) which encodes part of a receptor present in the cell wall of the stigma; •SRK (S-Receptor Kinase), which encodes the other part of the receptor. Kinases attach phosphate groups to other proteins. SRK is transmembrane protein embedded in the plasma membrane of the stigma c ...
Catalogue of Activities Work Product – Mendelian Genetic Disorders
... variants from genome- wide analyses by placing them in the context of known pathogenic variants, other plausibly pathogenic variants and population variation 2. Annotate plausibly pathogenic variants with their likely functional impact using Ensembl tools to compare sequence and structural variants ...
... variants from genome- wide analyses by placing them in the context of known pathogenic variants, other plausibly pathogenic variants and population variation 2. Annotate plausibly pathogenic variants with their likely functional impact using Ensembl tools to compare sequence and structural variants ...
Science-2004-Tong-808-13 - San Diego Center for Systems Biology
... interactions are between genes with a similar or identical GO annotation (an eightfold increase; P ⬍ 10–322), which is a conservative estimate because we defined two GO attributes to be similar only if they were annotated with significantly overlapping sets of genes (5). In summary, the results of t ...
... interactions are between genes with a similar or identical GO annotation (an eightfold increase; P ⬍ 10–322), which is a conservative estimate because we defined two GO attributes to be similar only if they were annotated with significantly overlapping sets of genes (5). In summary, the results of t ...
Analysis of Gene Regulatory Network Motifs in
... However, the analysis of motifs on an evolutionary scale requires the data of many individuals from different evolutionary stages. These data are (currently) not available in biology. Therefore, it seems advisable to support the biological analysis with the results from computational models. Even th ...
... However, the analysis of motifs on an evolutionary scale requires the data of many individuals from different evolutionary stages. These data are (currently) not available in biology. Therefore, it seems advisable to support the biological analysis with the results from computational models. Even th ...
RNA-Seq
RNA-seq (RNA sequencing), also called whole transcriptome shotgun sequencing (WTSS), is a technology that uses the capabilities of next-generation sequencing to reveal a snapshot of RNA presence and quantity from a genome at a given moment in time.