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carbohydrate metabolism
carbohydrate metabolism

... occur in three different stages. These are: - initial break down of glucose to pyruvate in glycolysis, - further degradation of pyruvate to acetyl coenzyme A, and - finally complete oxidation of acetyl coenzyme A to water and carbon dioxide in the citric acid cycle. • Glycolysis (Greek: glyco,sugar; ...
Combining Inductive Logic Programming, Active
Combining Inductive Logic Programming, Active

... There is an Oracle that knows what happened You can only ask yes or no questions ...
Treatment of inherited metabolic disorders
Treatment of inherited metabolic disorders

... uncooked cornstarch, liver transplantation Autosomal recessive, overall incidence is 1:10000, frequent in Ashkenazi The diagnosis is based on clinical presentation, abnormal blood/plasma concentrations of glucose, lactate, uric acid, triglycerides, and lipids, and molecular genetic testing. ...
Enzymeregulation
Enzymeregulation

... meal rich in E). How to shut down synthesis of E? Cell's answer: Enzyme 1 is reversibly inhibited by E. Note that E is not the substrate, and chemically so different that it cannot bind to active site. How does E shut down Enzyme 1? Enz 1 is a special type of enzyme called an allosteric enzyme. It c ...
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Slide 1

... e. plays roles in blood clotting cascade ...
BIO00004C Molecular biology and biochemistry (PDF , 72kb)
BIO00004C Molecular biology and biochemistry (PDF , 72kb)

... introduction to lipid and carbohydrate structures, the role of the various macromolecules in the context of membrane flow, cell shape, etc. will be discussed. Energy and metabolism is introduced by discussing the important concept of free energy and relating this to the central role of ATP and coupl ...
Project Description
Project Description

... the Columbia River estuary using culture-independent methods have found members of the Bacteroidetes to be a significant group present (Crump et al., AEM (65), 1999). The authors, in fact, commented that this group of bacteria “may be among the hallmark bacterial types in the Columbia River estuary. ...
The Physiological Roles of Enzymes
The Physiological Roles of Enzymes

... Prof. Dr. Hedef D. El-Yassin (Ph.D.,Post Doctorate) ...
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Slide 1

... Aerobic catabolism permits much greater energy from the breakdown of glucose (and other compounds) than is possible under anaerobic conditions. This high yield, however, comes at the price of potential poisoning by intermediates in the reduction of oxygen. These intermediates are termed reactive oxy ...
Text S1 Snitkin and Segrè, Epistatic interaction maps relative to
Text S1 Snitkin and Segrè, Epistatic interaction maps relative to

... phenotypes the cumulative interaction coverage was determined for all flux phenotypes, sorted by the number of unique interactions contributed (Figure 4). For this analysis interactions with respect to each phenotype were counted only if their multiplicative values were greater than one standard dev ...
ENZYMES: THE MAJESTIC MOLECULES OF LIFE Part
ENZYMES: THE MAJESTIC MOLECULES OF LIFE Part

... Urease crystals consisted entirely of protein. In 1930s, J.B.S. Haldane wrote a treatise entitled “Enzymes”. Haldane suggested that weak-bonding interactions between an enzyme and its substrate(s) might be used to distort the substrate and catalyze a reaction. This insight lies at the heart of our ...
Chap 5
Chap 5

... Bioprocess Engineering Chap 5 Major Metabolic Pathways I Introduction 1. Even the same species may produce different products when grown under different nutritional and environmental conditions 2. Metabolic pathways are subgroups as aerobic and anaerobic metabolism 3. Catabolism: the intracellular p ...
碩命題橫式 - 國立彰化師範大學圖書館
碩命題橫式 - 國立彰化師範大學圖書館

... 10. The direct sources of nitrogen that are used to make urea via the Urea Cycle are: (a). citrulline and ornithine (b). arginine and aspartate (c). arginine and citrulline (d). ammonia and arginine (e). aspartate and ammonia 11. Which product in glycolysis also involve in serine synthesis? (a) G6P. ...
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Supplementary Online Material

... target group that specifically inhibits cholesterol production consists of a long chain of enzymes directly involved in cholesterol biosynthesis (in accordance with the pathway annotation of these enzymes). In some cases, the pathway annotation of targets did not match their partition into target gr ...
Glutaric Acidemia Type 1 - Nutricia Learning Center
Glutaric Acidemia Type 1 - Nutricia Learning Center

... Written by: S. Kölker & P. Burgard Reviewed & Revised for North America by: S. van Calcar ...
Mitochondrial Function, Cellular Energy Flux and Hypoxia Analysis
Mitochondrial Function, Cellular Energy Flux and Hypoxia Analysis

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... We need one more oxygen in the products. Can’t change the formula, because it describes what it is (carbon monoxide in this example) ...
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8 Introduction to Metabolism Notes

... An Introduction to Metabolism I. ...
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Introduction to Metabolism Notes

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IB496-April 10 - School of Life Sciences
IB496-April 10 - School of Life Sciences

... Sucrose Phosphorylase Sucrose phosphorylase is the enzyme responsible for the conversion of sucrose to fructose and glucose-1-phosphate. This reaction is reversible. The enzyme is reported to have broad specificity, and so it may be possible for many other substrates to replace fructose as the gluc ...
Otras redes en Biología Molecular - Computational Systems Biology
Otras redes en Biología Molecular - Computational Systems Biology

... outputs, so inhibiting this protein on its own is not likely to achieve a separation of desired and undesired effects. If we want to inhibit cell-proliferation and cell-survival pathways, for example, without affecting glycogen metabolism, we would need multicomponent drugs to specifically inhibit t ...
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Slide 1

... – More stable the bonds of the substrate, the lower their free energy – More independent molecules included in the substrates, the lower their free energy ** above statements also apply to products of a reaction ...
metabolic stress response to surgery and trauma
metabolic stress response to surgery and trauma

... The ebb phase begins at the time of injury and last 24-48 hrs it may be attenuated by resuscit .but not completely abolished. The Ebb phase is characterized by hypovolemia, decreased basal metabolic rate, reduced cardiac output,hypothermia and lactic acidosis.The predominant hormones regulating the ...
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Metabolic network modelling



Metabolic network reconstruction and simulation allows for an in-depth insight into the molecular mechanisms of a particular organism. In particular, these models correlate the genome with molecular physiology. A reconstruction breaks down metabolic pathways (such as glycolysis and the Citric acid cycle) into their respective reactions and enzymes, and analyzes them within the perspective of the entire network. In simplified terms, a reconstruction collects all of the relevant metabolic information of an organism and compiles it in a mathematical model. Validation and analysis of reconstructions can allow identification of key features of metabolism such as growth yield, resource distribution, network robustness, and gene essentiality. This knowledge can then be applied to create novel biotechnology.In general, the process to build a reconstruction is as follows: Draft a reconstruction Refine the model Convert model into a mathematical/computational representation Evaluate and debug model through experimentation↑
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